Transversus Abdominis Plane Block Versus Quadratus Lumborum Block for Pain Management in Laparoscopic Appendectomy

Not Applicable

Completed

• Conditions: Surgery; Post Operative Pain; Appendicitis Acute
• Interventions: Procedure: Quadratus Lumborum Block; Procedure: Transversus abdominis plane block

• Registration Number: NCT05310266
• Lead Sponsor: Bakirkoy Dr. Sadi Konuk Research and Training Hospital

Brief Summary

Laparoscopic appendectomy causes postoperative pain. The primary objective of this prospective randomized controlled study is to compare the effect of ultrasound (US)-guided quadratus lumborum block (QLB) on 24-hour cumulative opioid requirements with transversus abdominis plane (TAP) block.

Detailed Description

168 patients (ASA I-II-III) between 18 and 65 years of age, who were to undergo laparoscopic appendectomy, were randomized and divided into two groups. 32 patients were dropout for different reasons.(68 patients in each of the TAP block and QLB block groups). TAP block was performed for TAP group and QLB block was performed for QLB group. Postoperative analgesia was provided by intravenous tramadol hydrochloride using a patient-controlled analgesia device. 24-hour total tramadol hydrochloride consumption was primary outcome measure.Postoperative numeric rating scale values were the secondary outcome measure.

Study Timeline

• Study Start: 2020-04-06
• Primary Completion: 2021-11-17
• Study Completion: 2022-02-21
• Study First Submitted: 2022-03-26
• Study First Submitted QC: 2022-03-26
• Study First Posted: 2022-04-04
• Status Verified: 2022-07
• Last Update Submitted: 2022-07-25
• Last Update Posted: 2022-07-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 168

Inclusion Criteria

• Ages of 18-65
• Patients who will undergo laparoscopic appendectomy
• ASA I-II-III patients

Exclusion Criteria

• Clinically known local anesthetic allergy
• Morbid obesity (body mass index>40 kg m2)
• Clinically diagnosis of opioid, alcohol and substance dependence
• Clinically diagnosis of psychiatric disease
• Coagulopathy
• Patients with ASA IV-V

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group QLB	Quadratus Lumborum Block	The investigators performed quadratus lumborum block to that patient group for postoperative analgesia
Group TAP	Transversus abdominis plane block	The investigators performed transversus abdominis plane block to that patient group for postoperative analgesia

Primary Outcome Measures

Name	Time	Method
Postoperative 24-hours total tramadol hydrochloride consumption	24 hours postoperatively	This will be measured by pca device in the 24 hour after

Secondary Outcome Measures

Name	Time	Method
Numerical rating scale (NRS) scores of patients	24 hours postoperatively	Numerical rating scale (NRS) at 1, 6, 12, 18, 24th hours. A numerical rating scale (NRS) requires the patient to rate their pain on a defined scale. For example, 0-10 where 0 is no pain and 10 is the worst pain imaginable.

Trial Locations

Locations (1)

Bakirkoy Dr. Sadi Konuk Research and Training Hospital; 🇹🇷 Istanbul, Bakirkoy, Turkey