Effect of synbiotics on intestinal environment in healthy subjects

Not Applicable

• Conditions: Healthy adults

• Registration Number: JPRN-UMIN000037753
• Lead Sponsor: Ezaki Glico Co., Ltd.

Brief Summary

niFrac distance analysis results showed a significant change in the gut microbiome composition of synbiotics group in comparison with that of placebo group. During the intervention period in synbiotics group, there was an increase in the abundance ratio of genus Bifidobacterium and Anaerostipes and a decrease in genus Clostridium. The quantitative PCR results showed that the total number of fecal Bifidobacterium significantly increased in only synbiotics group during the intervention period.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2019-12-06
• Study Start: 2020-10-01
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Not provided

Exclusion Criteria

1.Subjects who regularly use intestinal and constipation drugs (including strong laxatives) 2.Subjects who are heavy drinkers or alcoholics. 3.Subjects who consume following foods (daily or during ingestion period): food containing lactic acid bacteria and bifidobacteria (fermented milk, beverages, supplement etc.,), prebiotics and oligosaccharides, food containing a large amount of dietary fiber (beverages, supplements etc.,) 4.Subjects who have a disease that requires emergency treatment, or have serious complications 5.Subjects who have a medical history of digestive diseases or surgeries affecting digestion and absorption 6.Subjects with food allergy 7.Subjects who are pregnant or plan to become pregnant , or breast-feeding during the study 8.Subjects who are participating in other clinical trials that intake/apply any foods or drugs.

Study & Design

• Study Type: Interventional
• Study Design: Not specified