Time Course of Postprandial Protein Metabolism
- Conditions
- Protein MetabolismMuscle Protein Synthesis
- Registration Number
- NCT04121689
- Lead Sponsor
- University of Illinois at Urbana-Champaign
- Brief Summary
The anabolic action of 'fast' whey protein on the regulation of postprandial muscle protein synthesis has been established to be short-lived in healthy young adults. Our aim was assess the time course of anabolic signaling events and stimulation of muscle protein synthesis rates (MPS) after ingestion of a food source that represents a more typical meal-induced pattern of aminoacidemia, namely milk protein concentrate, in healthy young males.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 7
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Fractional synthesis rates of myofibrillar protein 8 hours Myofibrillar protein synthesis rates will be assessed during the postabsorptive period for 3 hours, and every 1-2 hours during the 5 hours after protein ingestion. This will allow us assess the timecourse of muscle protein synthesis after eating.
- Secondary Outcome Measures
Name Time Method Exogenous rate of phenylalanine appearance 5 hours Dietary derived phenylalanine availability will be measured during the 5 h postprandial phase to determine its relationship with the fractional synthesis rates of myofibrillar protein and phosphorylation of muscle anabolic signaling
Phosphorylation of muscle anabolic signaling 8 hours Phosphorylation of anabolic signaling pathways (mTORC1, AKT, and P70S6K) involved in the stimulation of myofibrillar protein synthesis rates will be assessed during the postabsorptive period for 3 hours, and every 1-2 hours during the 5 hours after protein ingestion.
Trial Locations
- Locations (1)
Freer Hall
🇺🇸Urbana, Illinois, United States
Freer Hall🇺🇸Urbana, Illinois, United States