Ketorolac

Generic Name
Ketorolac
Brand Names
Acular, Acuvail, Omidria, Readysharp Anesthetics Plus Ketorolac, Sprix, Toradol, Toronova Suik
Drug Type
Small Molecule
Chemical Formula
C15H13NO3
CAS Number
74103-06-3
Unique Ingredient Identifier
YZI5105V0L
Background

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.

It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis. Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.

Indication

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and has antipyretic, analgesic and anti-inflammatory properties. It is indicated for short term management of acute pain that requires the calibre of pain management offered by opioids. Clinicians may choose to initiate ketorolac to manage post-operative pain, spinal and soft tissue pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders and headaches among other ailments. Regardless of the etiology of pain, patients should use the lowest possible dose, and avoid using ketorolac for an extended period of time (ideally ≤ 5 days). A benefit of choosing ketorolac over other analgesics with similar potency is that that there does not appear to be a risk of dependence or tolerance with ketorolac use.

Associated Conditions
Acute Migraine, Eye Pain, Inflammation, Macular Edema, Cystoid, Ocular Itching, Pericarditis Acute, Pseudophakic Cystoid Macular Oedema, Severe Acute Pain, Acute, moderate Pain, Chronic aphakic cystoid macular edema, Intraoperative miosis, Postoperative ocular pain
Associated Therapies
-

Prospective Effect of Intravenous Ketorolac on Opioid Use, EBL and Complications Following Cesarean Delivery

First Posted Date
2015-07-28
Last Posted Date
2022-06-07
Lead Sponsor
University Hospitals Cleveland Medical Center
Target Recruit Count
70
Registration Number
NCT02509312
Locations
🇺🇸

University Hospitals Case Medical Center, Cleveland, Ohio, United States

Magnesium Sulfate Improves Postoperative Analgesia in Laparoscopic Gynecologic Surgeries

First Posted Date
2015-07-27
Last Posted Date
2015-07-27
Lead Sponsor
Instituto do Cancer do Estado de São Paulo
Target Recruit Count
60
Registration Number
NCT02508857
Locations
🇧🇷

Angela Maria Sousa, Sao Paulo, São Paulo, Brazil

Implementation of a Pain Management Protocol for Total Knee Arthroplasty

First Posted Date
2015-06-18
Last Posted Date
2019-01-18
Lead Sponsor
Health Sciences North Research Institute
Target Recruit Count
220
Registration Number
NCT02474654
Locations
🇨🇦

Health Sciences North Research Institute, Sudbury, Ontario, Canada

Femoral Nerve Block Compared to Exparel in Total Knee Replacement

First Posted Date
2015-06-16
Last Posted Date
2016-03-17
Lead Sponsor
The New England Baptist Hospital
Target Recruit Count
312
Registration Number
NCT02473198
Locations
🇺🇸

New England Baptist Hospital, Boston, Massachusetts, United States

Evaluation of GTPase Inhibition by Post-operative Intravenous Ketorolac in Ovarian Cancer Patients

Not Applicable
Active, not recruiting
Conditions
Interventions
First Posted Date
2015-06-12
Last Posted Date
2024-01-11
Lead Sponsor
New Mexico Cancer Care Alliance
Target Recruit Count
21
Registration Number
NCT02470299
Locations
🇺🇸

Universtiy of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico, United States

A Randomized Controlled Trial of IV Ketorolac to Prevent Post-ERCP Pancreatitis

Phase 4
Withdrawn
Conditions
Interventions
First Posted Date
2015-06-08
Last Posted Date
2022-04-28
Lead Sponsor
University of California, San Francisco
Registration Number
NCT02465138
Locations
🇺🇸

UCSF/San Francisco General Hospital, San Francisco, California, United States

🇺🇸

San Francisco General Hospital, San Francisco, California, United States

Sublingual Analgesia for Acute Abdominal Pain in Children

First Posted Date
2015-06-08
Last Posted Date
2017-08-22
Lead Sponsor
IRCCS Burlo Garofolo
Target Recruit Count
210
Registration Number
NCT02465255
Locations
🇮🇹

IRCCS Burlo Garofolo, Trieste, Friuli Venezia Giulia, Italy

Preemptive Ketorolac for Shoulder Tip Pain During Cesarean Section

Phase 4
Completed
Conditions
Interventions
First Posted Date
2015-03-05
Last Posted Date
2017-09-14
Lead Sponsor
Assiut University
Target Recruit Count
200
Registration Number
NCT02380898
Locations
🇪🇬

Assiut University hospital, Assiut, Egypt

Synergistic Pharmacologic Intervention for Prevention of ROP (SPIPROP Study)

First Posted Date
2015-01-22
Last Posted Date
2020-05-01
Lead Sponsor
State University of New York - Downstate Medical Center
Target Recruit Count
14
Registration Number
NCT02344225
Locations
🇺🇸

SUNY Downstate Medical Center/University Hospital of Brooklyn, Brooklyn, New York, United States

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