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Ketorolac

Generic Name
Ketorolac
Brand Names
Acular, Acuvail, Omidria, Readysharp Anesthetics Plus Ketorolac, Sprix, Toradol, Toronova Suik
Drug Type
Small Molecule
Chemical Formula
C15H13NO3
CAS Number
74103-06-3
Unique Ingredient Identifier
YZI5105V0L
Background

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.

It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis. Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.

Indication

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and has antipyretic, analgesic and anti-inflammatory properties. It is indicated for short term management of acute pain that requires the calibre of pain management offered by opioids. Clinicians may choose to initiate ketorolac to manage post-operative pain, spinal and soft tissue pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders and headaches among other ailments. Regardless of the etiology of pain, patients should use the lowest possible dose, and avoid using ketorolac for an extended period of time (ideally ≤ 5 days). A benefit of choosing ketorolac over other analgesics with similar potency is that that there does not appear to be a risk of dependence or tolerance with ketorolac use.

Associated Conditions
Acute Migraine, Eye Pain, Inflammation, Macular Edema, Cystoid, Ocular Itching, Pericarditis Acute, Pseudophakic Cystoid Macular Oedema, Severe Acute Pain, Acute, moderate Pain, Chronic aphakic cystoid macular edema, Intraoperative miosis, Postoperative ocular pain
Associated Therapies
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A Comparison of Prostaglandin E2 (PGE2) Inhibition of Acuvail(Ketorolac 0.45%), Xibrom (Bromfenac 0.09%)and Nevanac (Nepafenac)in Patients Undergoing Phacoemulsification

Phase 4
Completed
Conditions
Cataracts
Interventions
First Posted Date
2009-11-30
Last Posted Date
2011-08-31
Lead Sponsor
Frank A. Bucci, Jr., M.D.
Target Recruit Count
126
Registration Number
NCT01021761

Safety and Efficacy Study of KAI-1678 to Treat Subjects With Postoperative Pain

Phase 2
Completed
Conditions
Pain, Postoperative
Interventions
First Posted Date
2009-11-18
Last Posted Date
2011-09-02
Lead Sponsor
KAI Pharmaceuticals
Target Recruit Count
90
Registration Number
NCT01015235

Metoclopramide Versus Ketorolac for Tension-type Headache

Phase 4
Completed
Conditions
Headache
Interventions
First Posted Date
2009-11-11
Last Posted Date
2018-05-15
Lead Sponsor
Montefiore Medical Center
Target Recruit Count
123
Registration Number
NCT01011673
Locations
🇺🇸

Montefiore Medical Center, Bronx, New York, United States

Steroids After Laser Trabeculoplasty for Glaucoma

Phase 4
Completed
Conditions
Glaucoma
Interventions
First Posted Date
2009-09-22
Last Posted Date
2019-08-07
Lead Sponsor
Stanford University
Target Recruit Count
97
Registration Number
NCT00981435
Locations
🇺🇸

University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States

🇺🇸

Bascom Palmer Eye Institute, Miami, Florida, United States

Steroids Versus Non-steroidal Anti-inflammatory Drugs Following Glaucoma Surgery

Not Applicable
Conditions
Glaucoma
Interventions
First Posted Date
2009-08-11
Last Posted Date
2009-08-11
Lead Sponsor
University Health Network, Toronto
Target Recruit Count
36
Registration Number
NCT00956462
Locations
🇨🇦

Graham Trope, Toronto, Ontario, Canada

Topic Ketorolac Added to Panphotocoagulation in Proliferative Diabetic Retinopathy

Phase 2
Completed
Conditions
Macular Edema
Proliferative Diabetic Retinopathy
Interventions
First Posted Date
2009-05-22
Last Posted Date
2015-03-20
Lead Sponsor
Hospital Juarez de Mexico
Target Recruit Count
44
Registration Number
NCT00907114
Locations
🇲🇽

Virgilio Lima Gomez, Mexico, Distrito Federal, Mexico

Periarticular Multimodal Drug Injections in Total Knee Arthroplasty

Phase 4
Completed
Conditions
Osteoarthritis, Knee
Interventions
First Posted Date
2009-05-14
Last Posted Date
2013-01-25
Lead Sponsor
Seoul National University Hospital
Target Recruit Count
101
Registration Number
NCT00901628
Locations
🇰🇷

Joint Reconstruction Center, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea, Republic of

Topic Antiinflammatory Therapy Added to Selective Photocoagulation in Macular Edema

Phase 2
Completed
Conditions
Diabetic Retinopathy
Macular Edema
Interventions
Drug: Nepafenac
Drug: Polietilenglicol 400, propilenglicol
Drug: Ketorolac
First Posted Date
2009-05-13
Last Posted Date
2015-03-20
Lead Sponsor
Hospital Juarez de Mexico
Target Recruit Count
84
Registration Number
NCT00900887
Locations
🇲🇽

Virgilio Lima Gomez, Mexico, Distrito Federal, Mexico

A Comparison of Naropin and Ketorolac for Postoperative Analgesia After Total Knee Arthroplasty

Phase 4
Completed
Conditions
Postoperative Pain
Interventions
Drug: Saline
Drug: Ketorolac
First Posted Date
2009-03-25
Last Posted Date
2014-03-10
Lead Sponsor
University of Aarhus
Target Recruit Count
60
Registration Number
NCT00868348
Locations
🇩🇰

Aarhus University, Aarhus, Denmark

Post-Operative Treatment With Ketorolac After Abdominal Myomectomy

Not Applicable
Completed
Conditions
Febrile Morbidity
Pain
Interventions
Drug: saline
Drug: ketorolac
First Posted Date
2009-02-18
Last Posted Date
2009-02-18
Lead Sponsor
Ascher-Walsh, Charles, M.D.
Target Recruit Count
112
Registration Number
NCT00845754
Locations
🇺🇸

Columbia University Medical Center, New York, New York, United States

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