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Ketorolac

Generic Name
Ketorolac
Brand Names
Acular, Acuvail, Omidria, Readysharp Anesthetics Plus Ketorolac, Sprix, Toradol, Toronova Suik
Drug Type
Small Molecule
Chemical Formula
C15H13NO3
CAS Number
74103-06-3
Unique Ingredient Identifier
YZI5105V0L
Background

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.

It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis. Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.

Indication

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and has antipyretic, analgesic and anti-inflammatory properties. It is indicated for short term management of acute pain that requires the calibre of pain management offered by opioids. Clinicians may choose to initiate ketorolac to manage post-operative pain, spinal and soft tissue pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders and headaches among other ailments. Regardless of the etiology of pain, patients should use the lowest possible dose, and avoid using ketorolac for an extended period of time (ideally ≤ 5 days). A benefit of choosing ketorolac over other analgesics with similar potency is that that there does not appear to be a risk of dependence or tolerance with ketorolac use.

Associated Conditions
Acute Migraine, Eye Pain, Inflammation, Macular Edema, Cystoid, Ocular Itching, Pericarditis Acute, Pseudophakic Cystoid Macular Oedema, Severe Acute Pain, Acute, moderate Pain, Chronic aphakic cystoid macular edema, Intraoperative miosis, Postoperative ocular pain

NSAID Injection Versus Corticosteroid Injection for Basilar Thumb Arthritis

Phase 3
Recruiting
Conditions
Thumb Osteoarthritis
Interventions
First Posted Date
2023-08-15
Last Posted Date
2024-11-26
Lead Sponsor
Mayo Clinic
Target Recruit Count
240
Registration Number
NCT05992883
Locations
🇺🇸

Mayo Clinic, Rochester, Minnesota, United States

Intravenous Ketorolac Administration to Attenuate Post-procedural Pain Associated With Intrauterine Device Placement

Phase 4
Recruiting
Conditions
IUD
Healthy Female
Contraception
IUD Insertion Complication
Interventions
Drug: Placebo
First Posted Date
2023-05-25
Last Posted Date
2024-07-31
Lead Sponsor
Arkansas Children's Hospital Research Institute
Target Recruit Count
18
Registration Number
NCT05875571
Locations
🇺🇸

Arkansas Childrens Hospital, Little Rock, Arkansas, United States

Comparison of Patient-controlled Analgesia Regimenfor Postoperative Pain in Patients Undergoing Total Knee Arthroplasty

Not Applicable
Completed
Conditions
Postoperative Pain, Acute
Interventions
First Posted Date
2023-05-17
Last Posted Date
2024-07-15
Lead Sponsor
Chung-Ang University Gwangmyeong Hospital
Target Recruit Count
98
Registration Number
NCT05861791
Locations
🇰🇷

ChungAng University Gwangmyeong Hospital, Gyeonggi-do, Gwangmyeon-si, Korea, Republic of

NSAID Use After Robotic Partial Nephrectomy

Phase 2
Recruiting
Conditions
Renal Neoplasm
Renal Cancer
Kidney Cancer
Interventions
First Posted Date
2023-05-03
Last Posted Date
2024-10-08
Lead Sponsor
University of Miami
Target Recruit Count
110
Registration Number
NCT05842044
Locations
🇺🇸

University of Miami, Miami, Florida, United States

Intravenous Ibuprofen Versus Ketorolac in Bariatric Surgery

Not Applicable
Not yet recruiting
Conditions
Bariatric Surgery Candidate
Postoperative Pain
Interventions
First Posted Date
2023-04-06
Last Posted Date
2023-04-06
Lead Sponsor
Cairo University
Target Recruit Count
116
Registration Number
NCT05801900
Locations
🇪🇬

Cairo University, Cairo, Egypt

IV Ibuprofen vs Ketorolac in Post Operative Pain in Colorectal Cancer Surgeries in Obese Patient

Not Applicable
Completed
Conditions
Ibuprofen
Ketorolac
Colorectal Cancer
Interventions
First Posted Date
2023-03-23
Last Posted Date
2024-01-19
Lead Sponsor
Cairo University
Target Recruit Count
50
Registration Number
NCT05782608
Locations
🇪🇬

Ahmed Mahmoud Ismail Salama, Cairo, Egypt

Evaluation of the Effects of Ketorolac Dose on Duration of Analgesia in Emergency Department (ED) Renal Colic Patients

Phase 4
Active, not recruiting
Conditions
Flank Pain
Emergencies
Analgesia
Renal Colic
Interventions
First Posted Date
2023-03-20
Last Posted Date
2025-04-30
Lead Sponsor
Hackensack Meridian Health
Target Recruit Count
62
Registration Number
NCT05776953
Locations
🇺🇸

Hackensack Univarsity medical Center, Hackensack, New Jersey, United States

"NSAIDs vs. Opiates: Which is More Effective in Managing Pain in Mild to Moderate Acute Pancreatitis?

Early Phase 1
Recruiting
Conditions
Acute Pancreatitis
Interventions
First Posted Date
2023-03-06
Last Posted Date
2023-04-06
Lead Sponsor
Hayatabad Medical Complex
Target Recruit Count
130
Registration Number
NCT05756504
Locations
🇵🇰

Hayatabad Medical Complex, Peshawar, Kpk, Pakistan

Postoperative Analgesic Effects of Ibuprofen Versus Ketorolac in Patients Undergoing in Orthopedic Surgery

Early Phase 1
Completed
Conditions
Intravenous Drug Usage
Ketorolac
Knee Arthroscopy
Ibuprofen
Postoperative Pain
Interventions
First Posted Date
2023-01-25
Last Posted Date
2023-01-25
Lead Sponsor
Benazir Bhutto Hospital, Rawalpindi
Target Recruit Count
100
Registration Number
NCT05695664
Locations
🇵🇰

Fazal Hussain, Bhakkar, Punjab, Pakistan

Rectal Indomethacin vs Intravenous Ketorolac

Phase 4
Recruiting
Conditions
Post-ERCP Acute Pancreatitis
Interventions
First Posted Date
2022-12-23
Last Posted Date
2025-01-23
Lead Sponsor
David Vitale MD
Target Recruit Count
192
Registration Number
NCT05664074
Locations
🇺🇸

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States

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