Trimethoprim
- Generic Name
- Trimethoprim
- Brand Names
- Bactrim, Polytrim, Primsol, Septra, Sulfatrim
- Drug Type
- Small Molecule
- Chemical Formula
- C14H18N4O3
- CAS Number
- 738-70-5
- Unique Ingredient Identifier
- AN164J8Y0X
- Background
Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it prevents the synthesis of bacterial DNA and ultimately continued bacterial survival. Trimethoprim is often used in combination with sulfamethoxazole due to the...
- Indication
As a monotherapy, trimethoprim is indicated for the treatment of acute episodes of uncomplicated urinary tract infections caused by susceptible bacteria, including E. coli., K. pneumoniae, Enterobacter spp., P. mirabilis, and coagulase-negative Staphylococcus species. In various formulations in combination with sulfamethoxazole, trimethoprim is indicated for...
- Associated Conditions
- Acute Exacerbation of Chronic Bronchitis (AECB) caused by susceptible bacteria, Acute Otitis Media caused by susceptible bacteria, Bacterial Conjunctivitis caused by susceptible bacteria, Blepharoconjunctivitis caused by susceptible bacteria, Brucellosis, Dysentery, Bacillary, Nocardiosis, Pneumocystis Jirovecii Pneumonia, Urinary Tract Infection caused by susceptible bacteria, Bacterial blepharitis caused by susceptible bacteria, Susceptible Cholera, Susceptible Enteritis infectious caused by Shigella flexneri, Susceptible Enteritis infectious caused by Shigella sonnei, Susceptible Travelers' Diarrhea caused by Enterotoxigenic E. Coli (ETEC) Infection, Uncomplicated Urinary Tract Infection caused by susceptible bacteria
- Associated Therapies
- -
The Efficacy of Trimethoprim in Wound Healing of Patients With Epidermolysis Bullosa
- First Posted Date
- 2006-09-26
- Last Posted Date
- 2018-04-19
- Lead Sponsor
- The Hospital for Sick Children
- Target Recruit Count
- 10
- Registration Number
- NCT00380640
- Locations
- 🇨🇦
The Hospital for Sick Children, Toronto, Ontario, Canada
A Randomized, Double-Blind, Placebo Controlled Study of l-Leucovorin in Combination With Trimethoprim / Sulfamethoxazole in the Therapy of Pneumocystis Carinii Pneumonia in Patients With the Acquired Immunodeficiency Syndrome
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Lederle Laboratories
- Registration Number
- NCT00002002
- Locations
- 🇺🇸
San Francisco Gen Hosp, San Francisco, California, United States
A Comparison of Dapsone and Trimethoprim-Sulfamethoxazole in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Jacobus Pharmaceutical
- Registration Number
- NCT00002283
- Locations
- 🇺🇸
Jacobus Pharmaceutical Co, Princeton, New Jersey, United States
Islet Transplantation for Type 1 Diabetes
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2017-03-15
- Target Recruit Count
- 36
- Registration Number
- NCT00014911
- Locations
- 🇩🇪
Justus-Leibig University, Giessen, Germany
🇨🇦University of Alberta, Edmonton, Alberta, Canada
🇨🇭University of Geneva, Geneva, Switzerland
Randomized Phase I Study of Trimetrexate Glucuronate (TMTX) With Leucovorin (LCV) Protection Plus Dapsone Versus Trimethoprim / Sulfamethoxazole (TMP/SMX) for Treatment of Moderately Severe Episodes of Pneumocystis Carinii Pneumonia
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- U.S. Bioscience
- Target Recruit Count
- 20
- Registration Number
- NCT00002120
- Locations
- 🇺🇸
Los Angeles County / Health Research Assoc / Drew Med Ctr, Los Angeles, California, United States
Drug Development Updates
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