Nitazoxanide

Generic Name: Nitazoxanide

Brand Names: Alinia, Busulfex

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₉N_₃O_₅S

CAS Number: 55981-09-4

Unique Ingredient Identifier: SOA12P041N

Background: Nitazoxanide belongs to the class of drugs known as thiazolides. Nitazoxanide (NTZ) is a broad-spectrum anti-infective drug that markedly modulates the survival, growth, and proliferation of a range of extracellular and intracellular protozoa, helminths, anaerobic and microaerophilic bacteria, in addition to viruses. This drug is effective in the treatment o...

Indication: 用于治疗隐孢子虫、贾第鞭毛虫、阿米巴原虫引起的原虫性腹泻。

Associated Conditions: Diarrhea caused by Cryptosporidium parvum, Diarrhea caused by Giardia lamblia

Associated Therapies: -

Clinical Trials

Efficacy of Nitazoxanide in the Treatment of Chronic Hepatitis C Virus (HCV)

Phase 2

Completed

Conditions: Chronic Hepatitis c

Interventions: Drug: Pegylated interferon alfa-2a
Drug: Nitazoxanide
Drug: Ribavirin

First Posted Date: 2011-01-13

Last Posted Date: 2013-05-03

Lead Sponsor: Cairo University

Target Recruit Count: 100

Registration Number: NCT01276756

Locations: 🇪🇬
Cairo University, Cairo, Egypt

Safety and Efficacy Study of Nitazoxanide in the Treatment of Acute Uncomplicated Influenza

Phase 2

Completed

Conditions: Influenza

Interventions: Drug: Placebo
Drug: Nitazoxanide

First Posted Date: 2010-10-25

Last Posted Date: 2023-10-12

Lead Sponsor: Romark Laboratories L.C.

Target Recruit Count: 624

Registration Number: NCT01227421

Locations: 🇺🇸
Health Sciences Research Center, Elmira, New York, United States

Study of the Impact of Nitazoxanide on Chronic Hepatitis Patients

Phase 2

Completed

Conditions: Hepatitis C

Interventions: Drug: Placebo
Drug: Nitazoxanide

First Posted Date: 2010-09-09

Last Posted Date: 2014-09-30

Lead Sponsor: National Liver Institute, Egypt

Target Recruit Count: 200

Registration Number: NCT01197157

Locations: 🇪🇬
National Liver Institute, Shebin El-Kom, Menoufiya, Egypt

Hyperproteic Diet Plus Lactobacillus Reuteri and Nitazoxanide in Minimal Hepatic Encephalopathy

Not Applicable

Completed

Conditions: Minimal Hepatic Encephalopathy
Hepatic Cirrhosis

Interventions: Dietary Supplement: Hyperproteic and fiber-rich diet
Other: Auxiliary Treatment
Drug: Nitazoxanide

First Posted Date: 2010-06-03

Last Posted Date: 2014-08-20

Lead Sponsor: Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

Target Recruit Count: 60

Registration Number: NCT01135628

Locations: 🇲🇽
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico

A Pilot Study to Examine the Role of Nitazoxanide to Prevent Recurrence of Hepatitis C After Transplantation

Phase 1

Completed

Conditions: Hepatitis C Recurrence

Interventions: Drug: Nitazoxanide

First Posted Date: 2010-02-24

Last Posted Date: 2012-07-31

Lead Sponsor: Mayo Clinic

Target Recruit Count: 8

Registration Number: NCT01074203

Locations: 🇺🇸
Mayo Clinic College of Medicine, Rochester, Minnesota, United States

Study of Nitazoxanide in Adults With Acute Uncomplicated Influenza

Phase 2

Terminated

Conditions: Influenza

Interventions: Drug: Placebo
Drug: Nitazoxanide

First Posted Date: 2010-01-26

Last Posted Date: 2018-04-05

Lead Sponsor: Romark Laboratories L.C.

Target Recruit Count: 79

Registration Number: NCT01056380

Locations: 🇺🇸
Health Sciences Research Center at Asthma and Allergy Associates, P.C., Elmira, New York, United States

4-Week Lead-In With Nitazoxanide Followed by 36 Weeks Nitazoxanide and Peginterferon Alfa-2a in Chronic Hepatitis C

Phase 2

Completed

Conditions: Chronic Hepatitis C

Interventions: Drug: Nitazoxanide
Biological: Peginterferon alfa-2a

First Posted Date: 2008-10-01

Last Posted Date: 2008-10-01

Lead Sponsor: Romark Laboratories L.C.

Target Recruit Count: 40

Registration Number: NCT00763568

Locations: 🇪🇬
Digestive Disease Center, Tanta, Egypt

Use of Nitazoxanide and Probiotics in Acute Diarrhea Secondary to Rotavirus

Not Applicable

Completed

Conditions: Diarrhea
Rotavirus Infection

Interventions: Drug: Probiotic mix preparation
Other: Oral hydration solutions
Drug: Nitazoxanide

First Posted Date: 2008-05-26

Last Posted Date: 2008-05-26

Lead Sponsor: Centro Pediatrico Albina de Patino

Target Recruit Count: 75

Registration Number: NCT00683982

Locations: 🇧🇴
Centro Pediatrico Albina Patiño, Cochabamba, Bolivia

Study of Nitazoxanide, Peginterferon Alfa-2a and Ribavirin in Treatment-Naive Hepatitis C Patients

Phase 2

Completed

Conditions: Chronic Hepatitis C

Interventions: Drug: Placebo
Drug: Nitazoxanide
Biological: Peginterferon alfa-2a
Drug: Ribavirin

First Posted Date: 2008-03-18

Last Posted Date: 2014-02-10

Lead Sponsor: Romark Laboratories L.C.

Target Recruit Count: 112

Registration Number: NCT00637923

Locations: 🇺🇸
Florida Center for Gastroenterology, Largo, Florida, United States
🇺🇸
New York Presbyterian-Weill Medical College of Cornell University, New York, New York, United States
🇺🇸
Palo Alto VA Healthcare System, Palo Alto, California, United States

and more 7 locations

Study of Nitazoxanide, Peginterferon Alfa-2a and Ribavirin for the Treatment of Hepatitis C

Phase 2

Completed

Conditions: Chronic Hepatitis C

Interventions: Drug: Placebo
Drug: Nitazoxanide
Biological: Peginterferon alfa-2a
Drug: Ribavirin

First Posted Date: 2007-07-03

Last Posted Date: 2014-05-08

Lead Sponsor: Romark Laboratories L.C.

Target Recruit Count: 64

Registration Number: NCT00495391

Locations: 🇺🇸
VA Palo Alto Healthcare System, Palo Alto, California, United States
🇺🇸
McGuire VA Medical Center, Richmond, Virginia, United States
🇺🇸
Nashville Medical Research Institute, Nashville, Tennessee, United States

and more 7 locations

Drug Development Updates

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