Nitazoxanide

Generic Name
Nitazoxanide
Brand Names
Alinia, Busulfex
Drug Type
Small Molecule
Chemical Formula
C12H9N3O5S
CAS Number
55981-09-4
Unique Ingredient Identifier
SOA12P041N
Background

Nitazoxanide belongs to the class of drugs known as thiazolides. Nitazoxanide (NTZ) is a broad-spectrum anti-infective drug that markedly modulates the survival, growth, and proliferation of a range of extracellular and intracellular protozoa, helminths, anaerobic and microaerophilic bacteria, in addition to viruses. This drug is effective in the treatment o...

Indication

用于治疗隐孢子虫、贾第鞭毛虫、阿米巴原虫引起的原虫性腹泻。

Associated Conditions
Diarrhea caused by Cryptosporidium parvum, Diarrhea caused by Giardia lamblia
Associated Therapies
-
Clinical Trials
Related News

Efficacy and Safety of Nitazoxanide in Preventing Recurrence of Hepatic Encephalopathy

Phase 3
Recruiting
Conditions
Hepatic Encephalopathy
Interventions
Drug: Nitazoxanide
Drug: Rifaximin
First Posted Date
2019-11-13
Last Posted Date
2019-11-13
Lead Sponsor
Tanta University
Target Recruit Count
60
Registration Number
NCT04161053
Locations
🇪🇬

Sherief Abd-Elsalam, Tanta, Egypt

Study of Nitazoxanide Compared to Placebo in Subjects With HBeAG-Negative Chronic Hepatitis B

First Posted Date
2019-04-05
Last Posted Date
2023-11-07
Lead Sponsor
Romark Laboratories L.C.
Target Recruit Count
51
Registration Number
NCT03905655
Locations
🇸🇬

National University Hospital, Singapore, Singapore

Efficacy and Safety of Nitazoxanide in the Treatment of Colds Due to Enterovirus/Rhinovirus Infection

Phase 3
Completed
Conditions
Rhinovirus
Enterovirus
Interventions
Drug: Nitazoxanide
Drug: Placebo
First Posted Date
2018-07-30
Last Posted Date
2022-04-14
Lead Sponsor
Romark Laboratories L.C.
Target Recruit Count
1756
Registration Number
NCT03605862
Locations
🇵🇷

Vanguard Study Site, San Juan, Puerto Rico

NNITS-Nitazoxanide for Norovirus in Transplant Patients Study

Phase 2
Completed
Conditions
Gastroenteritis Norovirus
Interventions
Other: Placebo
Drug: Nitazoxanide
First Posted Date
2018-01-10
Last Posted Date
2023-10-11
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Target Recruit Count
31
Registration Number
NCT03395405
Locations
🇺🇸

Northwestern University - Comprehensive Transplant Center, Chicago, Illinois, United States

🇺🇸

Johns Hopkins Hospital - Medicine - Infectious Diseases, Baltimore, Maryland, United States

🇺🇸

University of Pittsburgh - Medicine - Infectious Diseases, Pittsburgh, Pennsylvania, United States

and more 9 locations

A Phase III, Randomized, Double-Blind, Placebo Controlled Trial to Evaluate the Efficacy and Safety of Nitazoxanide in the Treatment of Uncomplicated Influenza

Phase 3
Completed
Conditions
Influenza
Interventions
Drug: Nitazoxanide
Drug: Placebo
First Posted Date
2017-11-08
Last Posted Date
2022-06-28
Lead Sponsor
Romark Laboratories L.C.
Target Recruit Count
1030
Registration Number
NCT03336619
Locations
🇵🇷

Vanguard Study Site, Ponce, Puerto Rico

A 14 Day Early Bactericidal Activity Study of Nitazoxanide for the Treatment of Tuberculosis

Phase 2
Completed
Conditions
Tuberculosis
Interventions
Drug: Nitazoxanide
Other: Control
First Posted Date
2016-02-17
Last Posted Date
2020-08-05
Lead Sponsor
Weill Medical College of Cornell University
Target Recruit Count
30
Registration Number
NCT02684240
Locations
🇭🇹

Les Centres GHESKIO, Port-au-Prince, Haiti

A Two Week Nitazoxanidebased Quadruple Regimen

First Posted Date
2015-12-03
Last Posted Date
2018-01-03
Lead Sponsor
Tanta University
Target Recruit Count
100
Registration Number
NCT02621359
Locations
🇪🇬

Tropical medicine dept.-Tanta university hospital, Tanta, Egypt

Trial to Evaluate the Efficacy and Safety of Nitazoxanide in the Treatment of Acute Uncomplicated Influenza

Phase 3
Completed
Conditions
Influenza
Interventions
Drug: Placebo
Drug: Nitazoxanide
First Posted Date
2015-11-24
Last Posted Date
2018-04-04
Lead Sponsor
Romark Laboratories L.C.
Target Recruit Count
325
Registration Number
NCT02612922
Locations
🇵🇷

Influence Study Site, San Juan, Puerto Rico

Nitazoxanide Plus Lactulose Versus Lactulose Alone Treatment of Hepatic Encephalopathy

First Posted Date
2015-06-08
Last Posted Date
2017-08-21
Lead Sponsor
Sherief Abd-Elsalam
Target Recruit Count
120
Registration Number
NCT02464124
Locations
🇪🇬

Tanta university - faculty of medicine, Tanta, Elgharbia, Egypt

Finding Better Treatment of Bronchiolitis: A Clinical Trial of Oral Nitazoxanide for the Treatment of Bronchiolitis in Infants Presenting to Hospital Emergency Departments

First Posted Date
2015-05-25
Last Posted Date
2017-10-12
Lead Sponsor
Telethon Kids Institute
Registration Number
NCT02452905
Locations
🇦🇺

Telethon Kids Institute, Perth, Western Australia, Australia

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