Phenylephrine
- Generic Name
- Phenylephrine
- Brand Names
- 4-way, Advil Congestion Relief, Advil Sinus Congestion and Pain, Ala-hist PE, Allerest PE, Benadryl-D Allergy and Sinus, Biorphen, Cyclomydril, Dayquil Sinex, Deconex, Despec Reformulated Jun 2008, Dimetapp Nighttime Cold & Congestion, Diphen, Entex Lq, Gilphex, Histex Ac, Immphentiv, Little Noses Decongestant, M-end PE, Mucinex Stuffy Nose & Cold, Mydcombi, Mydfrin, Nasopen PE, Neo-synephrine, Omidria, Poly Hist Forte Reformulated Nov 2013, Preparation H Cooling Gel, Preparation H Cream, Preparation H Reformulated Jun 2013, Refenesen PE, Rescon-GG, Rymed-D, Soframycin, Sudafed PE, Sudafed PE Children's Cold & Cough, Sudafed PE Children's Nasal Decongestant, Sudafed PE Head Congestion Plus Pain, Sudafed PE Sinus Headache, Sudo-tab, Sudogest PE, Triaminic Day Time Cold & Cough, Triaminic Night Time Cold & Cough, Vazculep, Wal-profen Congestion Relief and Pain
- Drug Type
- Small Molecule
- Chemical Formula
- C9H13NO2
- CAS Number
- 59-42-7
- Unique Ingredient Identifier
- 1WS297W6MV
- Background
Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension, dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s.
Phenylephrine was granted FDA approval in 1939.
- Indication
Phenylephrine is available in various drug formulations, which have different indications. Phenylephrine injections are indicated to treat hypotension caused by shock or anesthesia. The ophthalmic formulation is indicated to induce mydriasis and conjunctival vasoconstriction. The intranasal formulation is used to treat congestion, and a topical formulation is used to treat hemorrhoids. Off-label uses include priapism and induction of local vasoconstriction.
- Associated Conditions
- Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergy to Tree Pollen, Anorectal discomfort, Cold, Common Cold, Congestion of the Conjunctivas, Cough, Cough caused by Common Cold, Eye allergy, Eye redness, Fever, Flu caused by Influenza, Haemorrhoids, Headache, Headache caused by Allergies, Headache caused by Common Cold, Headache caused by Pollen Allergy, Hypotension, Irritative cough, Itching of the nose, Itching of the throat, Laryngotracheitis, Nasal Congestion, Nose discomfort, Ocular Inflammation, Ocular Irritation, Paroxysmal Supraventricular Tachycardia (PSVT), Respiratory tract congestion, Respiratory tract irritation, Rhinopharyngitis, Rhinorrhoea, Seasonal Allergies, Sinus Congestion, Sinus pressure, Sinusitis, Sneezing, Sore Throat, Tracheobronchitis, Upper respiratory tract hypersensitivity reaction, site unspecified, Vasomotor Rhinitis, Aching caused by Flu caused by Influenza, Bronchial congestion, Cold or flu syndrome, Itchy throat, Minor aches and pains, Vascular failure, Watery itchy eyes
- Associated Therapies
- Airway secretion clearance therapy, Mydriasis, Antihistamine, Vasoconstrictor in regional analgesia therapy
Vasoactive Drugs in Intensive Care Unit
- Conditions
- Interventions
- First Posted Date
- 2014-04-21
- Last Posted Date
- 2024-12-09
- Lead Sponsor
- University of Chicago
- Target Recruit Count
- 836
- Registration Number
- NCT02118467
- Locations
- 🇺🇸
University of Chicago Medical Center, Chicago, Illinois, United States
Phenylephrine Dose and Mode of Administration for Spinal Anesthesia Induced Hypotension
- Conditions
- Interventions
- First Posted Date
- 2014-04-01
- Last Posted Date
- 2017-11-08
- Lead Sponsor
- Wake Forest University Health Sciences
- Registration Number
- NCT02101047
- Locations
- 🇺🇸
Novant Health Forsyth Medical Center, Winston-Salem, North Carolina, United States
Phenylephrine Versus Ephedrine in Pre-eclampsia
- First Posted Date
- 2014-01-01
- Last Posted Date
- 2020-10-14
- Lead Sponsor
- Duke University
- Target Recruit Count
- 13
- Registration Number
- NCT02025426
- Locations
- 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States
Vasopressors for Cerebral Oxygenation
- First Posted Date
- 2013-12-11
- Last Posted Date
- 2013-12-11
- Lead Sponsor
- Samsung Medical Center
- Target Recruit Count
- 50
- Registration Number
- NCT02009007
- Locations
- 🇰🇷
Samsung medical center, Seoul, Korea, Republic of
Evaluation of the Efficacy and Safety of Two Ibuprofen Combination Products for the Treatment of the Common Cold and Flu in Latin America
- Conditions
- Interventions
- First Posted Date
- 2013-09-10
- Last Posted Date
- 2015-10-14
- Lead Sponsor
- Pfizer
- Registration Number
- NCT01938144
Mechanisms of Vasovagal Syncope
- Conditions
- Interventions
- First Posted Date
- 2013-02-15
- Last Posted Date
- 2022-04-06
- Lead Sponsor
- New York Medical College
- Target Recruit Count
- 90
- Registration Number
- NCT01791816
- Locations
- 🇺🇸
New York Medical College/Bradhurst Building, Hawthorne, New York, United States
Phenylephrine Tumescence for Hemostasis in Surgery for Burn Injury
- First Posted Date
- 2012-11-21
- Last Posted Date
- 2024-12-05
- Lead Sponsor
- University of Manitoba
- Target Recruit Count
- 24
- Registration Number
- NCT01731444
- Locations
- 🇨🇦
University of Manitoba, Winnipeg, Manitoba, Canada
Phenylephrine Versus Norepinephrine in Ophthalmic Surgery
- First Posted Date
- 2012-06-01
- Last Posted Date
- 2024-04-18
- Lead Sponsor
- University Medical Center Groningen
- Target Recruit Count
- 60
- Registration Number
- NCT01609491
- Locations
- 🇳🇱
University Medical Center Groningen, Groningen, Netherlands
Safety and Efficacy of Therapeutic INduced HYPERTENSION in Acute Non-cardioembolic Ischemic Stroke (SETIN-HYPERTENSION)
- First Posted Date
- 2012-05-17
- Last Posted Date
- 2017-04-26
- Lead Sponsor
- Samsung Medical Center
- Target Recruit Count
- 170
- Registration Number
- NCT01600235
- Locations
- 🇰🇷
Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of
The Oxygenation of the Brain During Caesarean Section
- Conditions
- Interventions
- First Posted Date
- 2012-01-13
- Last Posted Date
- 2012-08-07
- Lead Sponsor
- Naestved Hospital
- Target Recruit Count
- 24
- Registration Number
- NCT01509521
- Locations
- 🇩🇰
Naestved Hospital, Naestved, Denmark
Drug Development Updates
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