Phenylephrine
- Generic Name
- Phenylephrine
- Brand Names
- 4-way, Advil Congestion Relief, Advil Sinus Congestion and Pain, Ala-hist PE, Allerest PE, Benadryl-D Allergy and Sinus, Biorphen, Cyclomydril, Dayquil Sinex, Deconex, Despec Reformulated Jun 2008, Dimetapp Nighttime Cold & Congestion, Diphen, Entex Lq, Gilphex, Histex Ac, Immphentiv, Little Noses Decongestant, M-end PE, Mucinex Stuffy Nose & Cold, Mydcombi, Mydfrin, Nasopen PE, Neo-synephrine, Omidria, Poly Hist Forte Reformulated Nov 2013, Preparation H Cooling Gel, Preparation H Cream, Preparation H Reformulated Jun 2013, Refenesen PE, Rescon-GG, Rymed-D, Soframycin, Sudafed PE, Sudafed PE Children's Cold & Cough, Sudafed PE Children's Nasal Decongestant, Sudafed PE Head Congestion Plus Pain, Sudafed PE Sinus Headache, Sudo-tab, Sudogest PE, Triaminic Day Time Cold & Cough, Triaminic Night Time Cold & Cough, Vazculep, Wal-profen Congestion Relief and Pain
- Drug Type
- Small Molecule
- Chemical Formula
- C9H13NO2
- CAS Number
- 59-42-7
- Unique Ingredient Identifier
- 1WS297W6MV
- Background
Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension, dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s.
Phenylephrine was granted FDA approval in 1939.
- Indication
Phenylephrine is available in various drug formulations, which have different indications. Phenylephrine injections are indicated to treat hypotension caused by shock or anesthesia. The ophthalmic formulation is indicated to induce mydriasis and conjunctival vasoconstriction. The intranasal formulation is used to treat congestion, and a topical formulation is used to treat hemorrhoids. Off-label uses include priapism and induction of local vasoconstriction.
- Associated Conditions
- Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergy to Tree Pollen, Anorectal discomfort, Cold, Common Cold, Congestion of the Conjunctivas, Cough, Cough caused by Common Cold, Eye allergy, Eye redness, Fever, Flu caused by Influenza, Haemorrhoids, Headache, Headache caused by Allergies, Headache caused by Common Cold, Headache caused by Pollen Allergy, Hypotension, Irritative cough, Itching of the nose, Itching of the throat, Laryngotracheitis, Nasal Congestion, Nose discomfort, Ocular Inflammation, Ocular Irritation, Paroxysmal Supraventricular Tachycardia (PSVT), Respiratory tract congestion, Respiratory tract irritation, Rhinopharyngitis, Rhinorrhoea, Seasonal Allergies, Sinus Congestion, Sinus pressure, Sinusitis, Sneezing, Sore Throat, Tracheobronchitis, Upper respiratory tract hypersensitivity reaction, site unspecified, Vasomotor Rhinitis, Aching caused by Flu caused by Influenza, Bronchial congestion, Cold or flu syndrome, Itchy throat, Minor aches and pains, Vascular failure, Watery itchy eyes
- Associated Therapies
- Airway secretion clearance therapy, Mydriasis, Antihistamine, Vasoconstrictor in regional analgesia therapy
Effect of Changing Physiological Conditions on Myogenic Oscillations: Pilot Study
- Conditions
- Interventions
- First Posted Date
- 2018-10-25
- Last Posted Date
- 2022-06-30
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 40
- Registration Number
- NCT03719001
- Locations
- 🇺🇸
University of California San Francisco, San Francisco, California, United States
Development of Advanced Double Intravenous Vasopressor Automated (ADIVA) System
- Conditions
- Interventions
- First Posted Date
- 2018-08-08
- Last Posted Date
- 2024-10-09
- Lead Sponsor
- KK Women's and Children's Hospital
- Target Recruit Count
- 173
- Registration Number
- NCT03620942
- Locations
- 🇸🇬
KK Women's and Children's Hospital, Singapore, Singapore
Preventive Intramuscular Phenylephrine in Elective Cesarean Section Under Spinal Anesthesia
- Conditions
- Interventions
- First Posted Date
- 2018-04-25
- Last Posted Date
- 2019-07-05
- Lead Sponsor
- Xuzhou Medical University
- Target Recruit Count
- 99
- Registration Number
- NCT03507387
- Locations
- 🇨🇳
The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China
Norepinephrine Versus Phenylephrine Continuous Variable Infusion in Cesarean Delivery
- Conditions
- Interventions
- First Posted Date
- 2017-11-01
- Last Posted Date
- 2018-07-17
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 123
- Registration Number
- NCT03328533
- Locations
- 🇪🇬
Cairo University, Cairo, Egypt
Vasopressor Infusion in Cesarean Delivery
- Conditions
- Interventions
- First Posted Date
- 2017-08-14
- Last Posted Date
- 2021-09-27
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 120
- Registration Number
- NCT03248791
- Locations
- 🇪🇬
Cairo University, Cairo, Egypt
Phenylephrine or Norepinephrine for a Better Hemodynamic Stability
- Conditions
- Interventions
- First Posted Date
- 2017-07-12
- Last Posted Date
- 2018-01-23
- Target Recruit Count
- 40
- Registration Number
- NCT03215797
Effect of Vasopressors on Spinal Anaesthesia Induced Hypotension
- Conditions
- Interventions
- First Posted Date
- 2017-05-23
- Last Posted Date
- 2019-10-24
- Lead Sponsor
- Cukurova University
- Target Recruit Count
- 160
- Registration Number
- NCT03163914
- Locations
- 🇹🇷
Çukurova University Balcalı Hospital, Adana, Turkey
The Effect of Brimonidine on Intraocular Pressure When Dilating Routine Patients
- Conditions
- Interventions
- First Posted Date
- 2017-05-04
- Last Posted Date
- 2018-08-09
- Lead Sponsor
- Wake Forest University Health Sciences
- Target Recruit Count
- 5
- Registration Number
- NCT03139708
- Locations
- 🇺🇸
Wake Forest Baptist Health Eye Center, Winston-Salem, North Carolina, United States
A Study of the Pharmacokinetic and Pharmacodynamic Responses in Healthy and Altered Human Cardiovascular Systems
- Conditions
- Interventions
- First Posted Date
- 2017-04-04
- Last Posted Date
- 2021-03-22
- Target Recruit Count
- 18
- Registration Number
- NCT03098680
- Locations
- 🇬🇧
Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom
Ephedrine and Phenylephrine for Spinal Hypotension
- First Posted Date
- 2017-02-08
- Last Posted Date
- 2020-10-27
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 60
- Registration Number
- NCT03047109
- Locations
- 🇪🇬
Assiut university hospital, Assiut, Egypt
Drug Development Updates
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