Chlorpromazine
- Generic Name
- Chlorpromazine
- Drug Type
- Small Molecule
- Chemical Formula
- C17H19ClN2S
- CAS Number
- 50-53-3
- Unique Ingredient Identifier
- U42B7VYA4P
- Background
The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
- Indication
For the treatment of schizophrenia; to control nausea and vomiting; for relief of restlessness and apprehension before surgery; for acute intermittent porphyria; as an adjunct in the treatment of tetanus; to control the manifestations of the manic type of manic-depressive illness; for relief of intractable hiccups; for the treatment of severe behavioral problems in children (1 to 12 years of age) marked by combativeness and/or explosive hyperexcitable behavior (out of proportion to immediate provocations), and in the short-term treatment of hyperactive children who show excessive motor activity with accompanying conduct disorders consisting of some or all of the following symptoms: impulsivity, difficulty sustaining attention, aggressivity, mood lability, and poor frustration tolerance.
- Associated Conditions
- Acute Intermittent Porphyria (AIP), Apprehension, Defiant Disorder, Oppositional, Intractable hiccups, Mania, Nausea and vomiting, Restlessness, Schizophrenia, Tetanus, Severe behavioural problems, Short term Hyperactivity
The Effect of Chlorpromazine on Esophageal Sensitivity in Healthy Volunteers.
- Conditions
- Esophageal Reflux
- Interventions
- First Posted Date
- 2017-06-12
- Last Posted Date
- 2017-06-12
- Lead Sponsor
- Universitaire Ziekenhuizen KU Leuven
- Target Recruit Count
- 14
- Registration Number
- NCT03183310
- Locations
- 🇧🇪
Targid, KU Leuven, Leuven, Vlaams-Brabant, Belgium
Haloperidol With or Without Chlorpromazine in Treating Delirium in Patients With Advanced, Metastatic, or Recurrent Cancer
- Conditions
- DeliriumLocally Advanced Malignant NeoplasmMetastatic Malignant NeoplasmRecurrent Malignant NeoplasmAdvanced Malignant Neoplasm
- Interventions
- Other: Quality-of-Life AssessmentOther: Questionnaire Administration
- First Posted Date
- 2017-01-16
- Last Posted Date
- 2025-03-20
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 70
- Registration Number
- NCT03021486
- Locations
- 🇺🇸
M D Anderson Cancer Center, Houston, Texas, United States
Assessment of Intra-subject Variability in the Bioavailability of Chlorpromazine Hydrochloride
- Conditions
- Anti-PsychoticControl Manifestations of the Manic Type of Mani-depressive IllnessControl Nausea and VomitingAdjunct in the Treatment of TetanusRelief of Intractable HiccupsManagement of Manifestations of Psychotic DisordersAcute Intermittent PorphyriaTreatment of SchizophreniaRelief of Restlessness and Apprehension Before Surgery
- Interventions
- First Posted Date
- 2016-10-24
- Last Posted Date
- 2017-11-14
- Lead Sponsor
- Cycle Pharmaceuticals Ltd.
- Target Recruit Count
- 20
- Registration Number
- NCT02943213
- Locations
- 🇿🇦
Farmovs Parexel, Bloemfontein, Kampuslaan Suid, South Africa
How to Treat Opiate Withdrawal in Neonates
- Conditions
- Neonatal Abstinence Syndrome
- Interventions
- First Posted Date
- 2016-06-23
- Last Posted Date
- 2020-01-07
- Lead Sponsor
- University of Zurich
- Target Recruit Count
- 120
- Registration Number
- NCT02810782
Family Intervention in Recent Onset Schizophrenia Treatment (FIRST)
- Conditions
- Schizophrenia
- Interventions
- Other: Caregiver psycho-education and skills trainingOther: Caregiver support available at the study site
- First Posted Date
- 2015-11-09
- Last Posted Date
- 2019-01-23
- Lead Sponsor
- Janssen Scientific Affairs, LLC
- Target Recruit Count
- 296
- Registration Number
- NCT02600741
Use of Intravitreal Triamcinolone and Retrobulbar Chlorpromazine as Alternatives to the Management of Painful Blind Eye
- Conditions
- Blind Painful EyeRefractory GlaucomaControl of Pain Through Drug Injection
- Interventions
- First Posted Date
- 2011-07-28
- Last Posted Date
- 2011-07-28
- Lead Sponsor
- Hospital Governador Celso Ramos
- Target Recruit Count
- 36
- Registration Number
- NCT01404364
- Locations
- 🇧🇷
Hospital Governador Celso Ramos, Florianopolis, Santa Catarina, Brazil
Efficacy and Safety of Quetiapine Fumarate in the Treatment of Schizophrenic Patients
- Conditions
- Schizophrenia
- Interventions
- First Posted Date
- 2009-04-16
- Last Posted Date
- 2012-05-15
- Lead Sponsor
- AstraZeneca
- Target Recruit Count
- 388
- Registration Number
- NCT00882518
- Locations
- 🇨🇳
Research Site, Shanghai, China
Comparison of Combination Olanzapine+Lithium or Chlorpromazine+Lithium in Treatment of First Manic Episode With Psychotic Features
- Conditions
- Bipolar DisorderSchizoaffective Disorder
- Interventions
- First Posted Date
- 2005-09-20
- Last Posted Date
- 2018-08-31
- Lead Sponsor
- Melbourne Health
- Target Recruit Count
- 83
- Registration Number
- NCT00202293
- Locations
- 🇦🇺
ORYGEN Youth Health, Parkville, Victoria, Australia
Clozapine Versus Chlorpromazine for Treatment-Unresponsive Schizophrenia
- Conditions
- Schizophrenia
- First Posted Date
- 2005-09-15
- Last Posted Date
- 2015-04-07
- Lead Sponsor
- Harvard Medical School (HMS and HSDM)
- Target Recruit Count
- 66
- Registration Number
- NCT00169039
- Locations
- 🇺🇸
Commonwealth Research Center, Jamaica Plain, Massachusetts, United States
Drug Development Updates
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