Sodium bicarbonate
- Generic Name
- Sodium bicarbonate
- Brand Names
- Alka-seltzer, Alka-seltzer Fruit Chews, Alka-seltzer Heartburn Relief, Bi-peglyte, Bibag, Bicart, Bss Ophthalmic Solution, Ceo-two, Colyte, Gavilyte-C, Gavilyte-G, Gavilyte-H and Bisacodyl, Gavilyte-N, Golytely, H.E.L.P.bicel, Hema Bp-38, Hemacart, Konvomep, Nulytely, Peglyte, Phoxillum, Physioneal 40, Prismasol, Zegerid, Zegerid Reformulated Aug 2006, Zegerid With Magnesium Hydroxide
- Drug Type
- Small Molecule
- Chemical Formula
- CHNaO3
- CAS Number
- 144-55-8
- Unique Ingredient Identifier
- 8MDF5V39QO
- Background
Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
- Indication
Sodium bicarbonate is used for the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Also is indicated in severe diarrhea which is often accompanied by a significant loss of bicarbonate. Further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturateprotein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of blood pigments.
- Associated Conditions
- Barbiturate intoxication, Breast Cancer, Constipation, Dental Decay, Duodenal Ulcer, Dyspepsia, Gastro-esophageal Reflux Disease (GERD), Gingival Bleeding, Heartburn, Helicobacter Infections, Hyperkalemia, Ischaemia, Metabolic Acidosis, Myocardial Infarction, Plaque, Dental, Pruritis of the skin, Skin Irritation, Upper GI Bleeding, Upset stomach, Zollinger-Ellison Syndrome, Abdominal bloating, Benign, active Gastric Ulcer, Methyl alcohol poisoning, Prophylaxis of Contrast-induced nephropathy, Salicylate poisoning, Severe Diarrhea, Swelling of the gums
- Associated Therapies
- Bowel preparation therapy
Effect of Sodium Bicarbonate Buccal Infiltration on the Success of Inferior Alveolar Nerve Block
- Conditions
- Local Anesthesia
- Interventions
- First Posted Date
- 2016-04-04
- Last Posted Date
- 2016-04-05
- Lead Sponsor
- Masoud Saatchi
- Target Recruit Count
- 100
- Registration Number
- NCT02726737
- Locations
- 🇮🇷
Isfahan University of Medical Sciences, Isfahan, Iran, Islamic Republic of
Optimal Lidocaine Buffering to Reduce Injection Pain in Local Anesthesia
- First Posted Date
- 2016-01-06
- Last Posted Date
- 2023-08-21
- Lead Sponsor
- University of Nebraska
- Target Recruit Count
- 70
- Registration Number
- NCT02647892
- Locations
- 🇺🇸
University of Nebraska Medical Center, Omaha, Nebraska, United States
Laser Ablation Versus Mechanochemical Ablation Trial
- Conditions
- Varicose Veins
- Interventions
- First Posted Date
- 2015-12-11
- Last Posted Date
- 2023-09-21
- Lead Sponsor
- Hull University Teaching Hospitals NHS Trust
- Target Recruit Count
- 150
- Registration Number
- NCT02627846
- Locations
- 🇬🇧
Hull and East Yorkshire Hospitals NHS Trust, Hull, United Kingdom
Extended Use of Sodium Bicarbonate in Patients With Cancer
- First Posted Date
- 2015-08-25
- Last Posted Date
- 2016-04-13
- Lead Sponsor
- University of Arizona
- Target Recruit Count
- 15
- Registration Number
- NCT02531919
- Locations
- 🇺🇸
University of Arizona Medical Center-University Campus, Tucson, Arizona, United States
Effect of Urinary Alkalinization on Urine Uric Acid Precipitation and Crystallization in Adults With Type 1 Diabetes
- Conditions
- Diabetic NephropathyDiabetic Kidney DiseaseType 1 Diabetes
- Interventions
- First Posted Date
- 2015-07-20
- Last Posted Date
- 2022-01-24
- Lead Sponsor
- University of Colorado, Denver
- Target Recruit Count
- 45
- Registration Number
- NCT02502071
- Locations
- 🇺🇸
Barbara Davis Center for Diabetes, Aurora, Colorado, United States
NAC, NaHCO3 and NS Prophylaxis for CTPA in the ED on Suspicion of PE: A Randomized Controlled Trial
- Conditions
- Radiographic Contrast Agent NephropathyPulmonary Embolism
- Interventions
- First Posted Date
- 2015-06-26
- Last Posted Date
- 2015-06-26
- Lead Sponsor
- Karadeniz Technical University
- Target Recruit Count
- 231
- Registration Number
- NCT02483143
- Locations
- 🇹🇷
Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey
Sodium Bicarbonate to Treat Severe Acidosis in the Critically Ill
- First Posted Date
- 2015-06-19
- Last Posted Date
- 2024-05-29
- Lead Sponsor
- University Hospital, Montpellier
- Target Recruit Count
- 400
- Registration Number
- NCT02476253
- Locations
- 🇫🇷
DAR St Eloi, Montpellier, France
Acid-Base Compensation in Chronic Kidney Disease
- Conditions
- Chronic Kidney Disease
- Interventions
- Other: Controlled diet
- First Posted Date
- 2015-04-28
- Last Posted Date
- 2017-08-30
- Lead Sponsor
- Duke University
- Target Recruit Count
- 14
- Registration Number
- NCT02427594
- Locations
- 🇺🇸
Duke University School of Medicine, Durham, North Carolina, United States
Sympatholysis in Chronic Kidney Disease
- Conditions
- Chronic Kidney Disease
- Interventions
- Drug: PlaceboBehavioral: Exercise TrainingBehavioral: Control to Exercise (Stretching)
- First Posted Date
- 2015-04-08
- Last Posted Date
- 2025-03-05
- Lead Sponsor
- Emory University
- Target Recruit Count
- 110
- Registration Number
- NCT02411773
- Locations
- 🇺🇸
Atlanta VA Medical Center, Decatur, Georgia, United States
Bicarbonate in Patients With Out-of-hospital Cardiac Arrest
- Conditions
- Cardiac ArrestMetabolic Acidosis
- Interventions
- Drug: Normal saline
- First Posted Date
- 2014-12-01
- Last Posted Date
- 2022-03-25
- Lead Sponsor
- Asan Medical Center
- Target Recruit Count
- 50
- Registration Number
- NCT02303548
Drug Development Updates
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