Cyclobenzaprine
- Generic Name
- Cyclobenzaprine
- Brand Names
- Amrix, Fexmid, Flexeril
- Drug Type
- Small Molecule
- Chemical Formula
- C20H21N
- CAS Number
- 303-53-7
- Unique Ingredient Identifier
- 69O5WQQ5TI
- Background
Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961 and has been available for human use since 1977. It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from Amitriptyline by only a single double bond. Since its approval, it has remained relatively popular as an adjunctive, short-term treatment for acute skeletal muscle spasms secondary to musculoskeletal injury.
- Indication
用于缓解与急性疼痛的肌肉骨骼疾病相关的肌肉痉挛（作为休息和物理治疗的辅助药）。但环苯扎林对脑、脊髓疾病或儿童脑性瘫痪引起的痉挛无效。
- Associated Conditions
- Muscle Spasms
Study Comparing A New Drug Containing The Combination Meloxicam And Cyclobenzaprine In The Treatment Of Acute Lumbago
- Conditions
- Acute Lumbago
- Interventions
- Drug: meloxicam/cyclobenzaprine hydrochloride
- First Posted Date
- 2012-04-30
- Last Posted Date
- 2016-05-03
- Lead Sponsor
- Eurofarma Laboratorios S.A.
- Registration Number
- NCT01587508
- Locations
- 🇧🇷
Santa Casa de Misericórdia de Belo Horizonte, Belo Horizonte, MG, Brazil
🇧🇷Clínica de Ortopedia e Fraturas de Goiânia, Goiania, GO, Brazil
🇧🇷Santa Casa de Votuporanga, Votuporanga, SP, Brazil
A Randomized Study of Three Medication Regimens for Acute Low Back Pain
- Conditions
- Acute Low Back Pain
- Interventions
- First Posted Date
- 2012-04-30
- Last Posted Date
- 2018-07-31
- Lead Sponsor
- Montefiore Medical Center
- Target Recruit Count
- 323
- Registration Number
- NCT01587274
- Locations
- 🇺🇸
Montefiore Medical Center, Bronx, New York, United States
Efficacy and Safety of Cyclobenzaprine Hydrochloride Extended Release for the Treatment of Chronic Migraine
- Conditions
- Chronic Migraine
- Interventions
- Drug: placebo
- First Posted Date
- 2010-06-28
- Last Posted Date
- 2014-07-25
- Lead Sponsor
- Kennedy Medical Group
- Target Recruit Count
- 35
- Registration Number
- NCT01151787
- Locations
- 🇺🇸
The Headache Center at Kennedy Health Alliance, Cherry Hill, New Jersey, United States
Use of Cyclobenzaprine After Vaginal Surgery
- First Posted Date
- 2010-03-05
- Last Posted Date
- 2019-09-10
- Lead Sponsor
- NorthShore University HealthSystem
- Target Recruit Count
- 63
- Registration Number
- NCT01081990
- Locations
- 🇺🇸
Evanston NorthShore University HealthSystem, Evanston, Illinois, United States
Cyclobenzaprine Extended Release (ER) for Fibromyalgia
- Conditions
- FibromyalgiaPainSleepFatigue
- Interventions
- Drug: placebo
- First Posted Date
- 2009-12-31
- Last Posted Date
- 2024-11-27
- Lead Sponsor
- State University of New York - Upstate Medical University
- Target Recruit Count
- 37
- Registration Number
- NCT01041495
- Locations
- 🇺🇸
SUNY Upstate Medical University, Syracuse, New York, United States
Medication Effects on Periurethral Sensation,Urethral Sphincter Activity and Pressure Flow Parameters
- Conditions
- Urethral Sphincter Activity
- Interventions
- First Posted Date
- 2009-12-09
- Last Posted Date
- 2012-06-08
- Lead Sponsor
- University of Alabama at Birmingham
- Target Recruit Count
- 56
- Registration Number
- NCT01028014
- Locations
- 🇺🇸
University of Alabama at Birmingham, The Kirklin Clinic, Birmingham, Alabama, United States
To Demonstrate the Relative Bioavailability of Cyclobenzaprine HCl Tablets
- Conditions
- Depression
- Interventions
- First Posted Date
- 2009-06-04
- Last Posted Date
- 2017-03-28
- Lead Sponsor
- Sandoz
- Target Recruit Count
- 30
- Registration Number
- NCT00913419
Comparison of Ibuprofen, Cyclobenzaprine, or Both for Acute Cervical Strain: A Randomized Clinical Trial
- Conditions
- Cervical Strain
- Interventions
- First Posted Date
- 2008-11-13
- Last Posted Date
- 2012-11-21
- Lead Sponsor
- Stony Brook University
- Target Recruit Count
- 61
- Registration Number
- NCT00790270
- Locations
- 🇺🇸
Stony Brook University, Stony Brook, New York, United States
Bioequivalence Study of Cyclobenzaprine Hydrochloride 10 mg Tablets, USP Under Fasting Conditions
- Conditions
- Healthy
- Interventions
- First Posted Date
- 2008-10-23
- Last Posted Date
- 2008-10-23
- Lead Sponsor
- Ranbaxy Laboratories Limited
- Target Recruit Count
- 40
- Registration Number
- NCT00778037
- Locations
- 🇮🇳
Ranbaxy CPU, Gurgaon, Haryana, India
An Effectiveness and Safety Study of Cyclobenzaprine HCl Alone or in Combination With Ibuprofen for Acute Back or Neck Muscle Pain With Muscle Spasm
- Conditions
- PainSpasm
- First Posted Date
- 2005-10-30
- Last Posted Date
- 2011-02-18
- Lead Sponsor
- McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.
- Target Recruit Count
- 1000
- Registration Number
- NCT00246389
Drug Development Updates
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