Sevoflurane

Generic Name: Sevoflurane

Brand Names: Sevorane, Sojourn, Ultane

Drug Type: Small Molecule

Chemical Formula: C_₄H_₃F_₇O

CAS Number: 28523-86-6

Unique Ingredient Identifier: 38LVP0K73A

Background: Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 1996. Sevoflurane is three times more potent than desflurane, but has lower potency compared to halothane and isoflurane. Unlike other volatile anesthetics, sevoflurane has a pleasant odor and does not irritate the airway. The hemodynamic and respiratory depressive effects of sevoflurane are well tolerated, and most patients receiving this anesthetic agent present little toxicity. Therefore, it can be used for inhalational induction in adults and children for a wide variety of anesthetic procedures.

Indication: Sevoflurane is used for the induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.

Associated Conditions: -

Associated Therapies: General Anesthesia, Induction and Maintenance of General Anesthesia

Clinical Trials

SIRS in Cyanotic and Acyanotic Children in Cardiac Surgery

Completed

Conditions: SIRS
Pediatric Cardiac Surgery

Interventions: Drug: Sevoflurane

First Posted Date: 2020-02-05

Last Posted Date: 2021-03-15

Lead Sponsor: Cukurova University

Target Recruit Count: 197

Registration Number: NCT04254744

Locations: 🇹🇷
Cukurova University, Adana, Turkey

The Influence of Type of Anesthesia on Postoperative Pain

Not Applicable

Active, not recruiting

Conditions: Colo-rectal Cancer
Anesthesia

Interventions: Drug: Sevoflurane
Drug: Propofol

First Posted Date: 2020-01-27

Last Posted Date: 2023-12-22

Lead Sponsor: Seoul National University Hospital

Target Recruit Count: 468

Registration Number: NCT04239794

Locations: 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of
🇰🇷
Seoul National University Bundang Hospital, Seoul, Korea, Republic of
🇰🇷
Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea, Republic of

Impact of Different Modes of Ventilation With Laryngeal Mask Airway on Pediatric Cataract Surgery

Not Applicable

Completed

Conditions: Laryngeal Mask Airway
Cataract Surgery
Ventilation

Interventions: Procedure: Pressure Support Ventilation
Procedure: Unparalyzed Pressure Control Ventilation
Procedure: Paralyzed Pressure Control Ventilation
Device: Laryngeal Mask Airway
Drug: Sevoflurane

First Posted Date: 2020-01-27

Last Posted Date: 2021-06-10

Lead Sponsor: Sameh Fathy

Target Recruit Count: 150

Registration Number: NCT04241653

Locations: 🇪🇬
Department of Anesthesia, Mansoura University Hospitals, Mansoura, Dakahlia, Egypt

End Tidal Anesthetic Concentration in Different Anesthesia Techniques Where Depth of Anesthesia Adjusted With Entropy

Not Applicable

Completed

Conditions: Inhalation; Gas
General Anesthesia

Interventions: Drug: Sevoflurane
Drug: Bupivacaine

First Posted Date: 2019-12-18

Last Posted Date: 2022-03-17

Lead Sponsor: Istanbul University

Target Recruit Count: 44

Registration Number: NCT04203290

Locations: 🇹🇷
İstanbul University, Istanbul, Turkey

Tolerance to Sevoflurane in Children Undergoing Repeated Drug Exposure

Completed

Conditions: Anesthesia
Tolerance

Interventions: Drug: Sevoflurane

First Posted Date: 2019-12-06

Last Posted Date: 2021-10-07

Lead Sponsor: University of Chile

Target Recruit Count: 24

Registration Number: NCT04188782

Locations: 🇨🇱
Instituto Nacional del Cancer, Santiago, Metropolitana, Chile
🇨🇱
Centro de Investigacion Clinica Avanzada, Santiago, Chile

The Effect of Total Intravenous Anesthesia and Volatile Anesthesia on Shedding of the Endothelial Glycocalyx in Patients Undergoing Laparoscopic or Robotic Assisted Gastrectomy

Not Applicable

Completed

Conditions: Gastrostomy

Interventions: Drug: propofol
Drug: sevoflurane

First Posted Date: 2019-12-03

Last Posted Date: 2020-09-22

Lead Sponsor: Yonsei University

Target Recruit Count: 136

Registration Number: NCT04183296

Locations: 🇰🇷
Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine, Seoul, Korea, Republic of