Sevoflurane

Generic Name: Sevoflurane

Brand Names: Sevorane, Sojourn, Ultane

Drug Type: Small Molecule

Chemical Formula: C_₄H_₃F_₇O

CAS Number: 28523-86-6

Unique Ingredient Identifier: 38LVP0K73A

Background: Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 1996. Sevoflurane is three times more potent than desflurane, but has lower potency compared to halothane and isoflurane. Unlike other volatile anesthetics, sevoflurane has a pleasant odor and does not irritate the airway. The hemodynamic and respiratory depressive effects of sevoflurane are well tolerated, and most patients receiving this anesthetic agent present little toxicity. Therefore, it can be used for inhalational induction in adults and children for a wide variety of anesthetic procedures.

Indication: Sevoflurane is used for the induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.

Associated Conditions: -

Associated Therapies: General Anesthesia, Induction and Maintenance of General Anesthesia

Clinical Trials

Total Knee Replacement TIVA With Robotic Arm Assisted

Phase 4

Recruiting

Conditions: Postoperative Pain

Interventions: Procedure: Spinal anaesthesia
Drug: Sevoflurane
Drug: Propofol

First Posted Date: 2019-06-28

Last Posted Date: 2023-05-10

Lead Sponsor: The University of Hong Kong

Target Recruit Count: 180

Registration Number: NCT04002271

Locations: 🇭🇰
Queen Mary Hospital, Hong Kong, Hong Kong
🇭🇰
The University of Hong Kong, Hong Kong, Hong Kong

Desflurane vs. Sevoflurane in Endovascular Aortic Repair

Phase 4

Completed

Conditions: Renal Failure

Interventions: Drug: Sevoflurane
Drug: Desflurane

First Posted Date: 2019-04-16

Last Posted Date: 2023-11-21

Lead Sponsor: Begoña Quintana Villamandos

Target Recruit Count: 80

Registration Number: NCT03917186

Locations: 🇪🇸
Hospital general universitario Gregorio Marañón, Madrid, Spain

Different Volatile Anaesthetics and the Depth of Long Term ICU Sedation

Not Applicable

Completed

Conditions: Intensive Care Unit Syndrome

Interventions: Drug: Isoflurane
Drug: Sevoflurane
Drug: Desflurane

First Posted Date: 2019-03-01

Last Posted Date: 2019-03-01

Lead Sponsor: Ruhr University of Bochum

Target Recruit Count: 30

Registration Number: NCT03860129

Comparation Analgesia Efficiency With Propofol Combine Sevoflurane vs Propofol

Phase 3

Completed

Conditions: Nociceptive Pain
Analgesic Adverse Reaction
Inhalant Use

Interventions: Drug: 5mg/kg/h Propofol
Drug: Sevoflurane
Drug: 2 mg/kg/h Propofol

First Posted Date: 2019-02-15

Last Posted Date: 2020-10-14

Lead Sponsor: China International Neuroscience Institution

Target Recruit Count: 146

Registration Number: NCT03841812

Locations: 🇨🇳
Xuanwu Hospital, Beijing, Beijing, China

Regional Anesthesia Versus General Anesthesia

Not Applicable

Completed

Conditions: Postoperative Pain
Anesthesia

Interventions: Drug: Midazolam
Drug: Sufentanil
Drug: Bupivacaine
Drug: Propofol
Drug: Rocuronium
Drug: Sevoflurane

First Posted Date: 2019-02-05

Last Posted Date: 2019-07-15

Lead Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna

Target Recruit Count: 28

Registration Number: NCT03830086

Locations: 🇮🇹
Cardiothoracic and Vascular Anesthesia and Intensive Care, S. OrsolaMalpighi University Hospital, Bologna, BO, Italy
🇮🇹
Gynecology and Physiopathology of Human Reproductive Unit, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, BO, Italy