Sevoflurane

Generic Name: Sevoflurane

Brand Names: Sevorane, Sojourn, Ultane

Drug Type: Small Molecule

Chemical Formula: C_₄H_₃F_₇O

CAS Number: 28523-86-6

Unique Ingredient Identifier: 38LVP0K73A

Background: Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 1996. Sevoflurane is three times more potent than desflurane, but has lower potency compared to halothane and isoflurane. Unlike other volatile anesthetics, sevoflurane has a pleasant odor and does not irritate the airway. The hemodynamic and respiratory depressive effects of sevoflurane are well tolerated, and most patients receiving this anesthetic agent present little toxicity. Therefore, it can be used for inhalational induction in adults and children for a wide variety of anesthetic procedures.

Indication: Sevoflurane is used for the induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.

Associated Conditions: -

Associated Therapies: General Anesthesia, Induction and Maintenance of General Anesthesia

Clinical Trials

Effect of Sevoflurane, Propofol and Dexmedetomidine on Delirium & Neuroinflammation in Mechanically Ventilated Patients

Phase 4

Withdrawn

Conditions: Delirium

Interventions: Drug: Sevoflurane
Drug: Dexmedetomidine
Drug: Propofol

First Posted Date: 2015-03-20

Last Posted Date: 2019-08-15

Lead Sponsor: Moscow Regional Research and Clinical Institute (MONIKI)

Registration Number: NCT02394418

Pharmacokinetics and Pharmacodynamics of Rocuronium in Closed-Loop Infusion System

Conditions: TOF
Sex

Interventions: Drug: Sevoflurane
Drug: Propofol

First Posted Date: 2015-02-18

Last Posted Date: 2015-02-26

Lead Sponsor: Tianjin Medical University General Hospital

Target Recruit Count: 240

Registration Number: NCT02364934

Automated Control of End-tidal Volatile Anesthetic Concentration

Not Applicable

Completed

Conditions: Delayed Recovery From Anesthesia

Interventions: Drug: Desflurane
Drug: Isoflurane
Drug: Sevoflurane

First Posted Date: 2015-01-21

Last Posted Date: 2015-01-21

Lead Sponsor: Ruhr University of Bochum

Target Recruit Count: 63

Registration Number: NCT02342509

Effects of Preconditioning With Sevoflurane During Organ Procurement From Brain Dead Donors: Impact on Early Function of Liver Allografts

Phase 4

Conditions: Post-transplantation Liver Allograft Function

Interventions: Drug: Sevoflurane

First Posted Date: 2015-01-19

Last Posted Date: 2015-01-21

Lead Sponsor: University of Liege

Target Recruit Count: 240

Registration Number: NCT02341833

Locations: 🇧🇪
Department of Anesthesiology, CHU Liège, Liège, Belgium

Remifentanil for Smooth Emergence in Elderly Patients

Phase 4

Completed

Conditions: Drug Usage

Interventions: Drug: Remifentanil
Drug: Sevoflurane

First Posted Date: 2015-01-08

Last Posted Date: 2015-12-18

Lead Sponsor: Ajou University School of Medicine

Target Recruit Count: 47

Registration Number: NCT02334046

Locations: 🇰🇷
Ajou University Hospital, Suwon, Gyeongki-do, Korea, Republic of

Emergence Times and Airway Reactions in General Laryngeal Mask Airway Anesthesia

Phase 3

Completed

Conditions: Anesthesia With Use of LMA (Laryngeal Mask Airway)

Interventions: Drug: Desflurane
Drug: propofol
Drug: Sevoflurane

First Posted Date: 2014-12-23

Last Posted Date: 2016-10-06

Lead Sponsor: RWTH Aachen University

Target Recruit Count: 352

Registration Number: NCT02322502

Locations: 🇩🇪
RWTH Aachen University; Department of Anesthesia, Aachen, Germany
🇩🇪
Kreiskliniken Reutlingen, Department of Anesthesia, Reutlingen, Germany
🇩🇪
University Hospital Ulm, Department of Anesthesia, Ulm, Germany

and more 1 locations