Sevoflurane

Generic Name: Sevoflurane

Brand Names: Sevorane, Sojourn, Ultane

Drug Type: Small Molecule

Chemical Formula: C_₄H_₃F_₇O

CAS Number: 28523-86-6

Unique Ingredient Identifier: 38LVP0K73A

Background: Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 1996. Sevoflurane is three times more potent than desflurane, but has lower potency compared to halothane and isoflurane. Unlike other volatile anesthetics, sevoflurane has a pleasant odor and does not irritate the airway. The hemodynamic and respiratory depressive effects of sevoflurane are well tolerated, and most patients receiving this anesthetic agent present little toxicity. Therefore, it can be used for inhalational induction in adults and children for a wide variety of anesthetic procedures.

Indication: Sevoflurane is used for the induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.

Associated Conditions: -

Associated Therapies: General Anesthesia, Induction and Maintenance of General Anesthesia

Clinical Trials

The Protective Effects of Sevoflurane in Pediatric Cardiac Surgery

Not Applicable

Conditions: Congenital Heart Diseases

Interventions: Other: Control
Drug: Sevoflurane

First Posted Date: 2011-10-13

Last Posted Date: 2011-11-28

Lead Sponsor: Xijing Hospital

Target Recruit Count: 100

Registration Number: NCT01450956

Locations: 🇨🇳
Department of Cardiovascular Surgery, Xijing Hospital, Xi'an, Shaanxi, China

Sevoflurane, Propofol, Postoperative Pain

Phase 4

Completed

Conditions: Healthy Adults
Gynecological Disease

First Posted Date: 2011-09-21

Last Posted Date: 2013-04-10

Lead Sponsor: Tampere University Hospital

Target Recruit Count: 168

Registration Number: NCT01437462

Locations: 🇫🇮
Tampere University Hospital, Tampere, Finland

Volatile Anesthetic Choice and Duration of Hospitalization: A Quality Improvement and Cost-control Project

Not Applicable

Completed

Conditions: Duration of Hospitalization

Interventions: Drug: Isoflurane
Drug: Sevoflurane

First Posted Date: 2011-06-23

Last Posted Date: 2017-04-10

Lead Sponsor: The Cleveland Clinic

Target Recruit Count: 1584

Registration Number: NCT01379664

Locations: 🇺🇸
Cleveland Clinic, Cleveland, Ohio, United States

Recovery Following Desflurane Versus Sevoflurane for Outpatient Urologic Surgery in Elderly Females

Phase 4

Completed

Conditions: Ureteral Stent Occlusion
Exposure Laser
Ureterostomy; Functional Disturbance
Vaginal Diseases
Injury of Bladder
Excessive Repair
Calculi

Interventions: Drug: Desflurane
Drug: Sevoflurane

First Posted Date: 2011-03-08

Last Posted Date: 2013-12-24

Lead Sponsor: Hahnemann University Hospital

Target Recruit Count: 57

Registration Number: NCT01310582

Locations: 🇺🇸
Hahnemann University Hospital, Philadelphia, Pennsylvania, United States

Xenon Compared to Sevoflurane and Total Intravenous Anaesthesia for Coronary Artery Bypass Graft Surgery

Phase 3

Completed

Conditions: Coronary Artery Disease
General Anesthetic Drug Allergy
Coronary Artery Bypass Graft Surgery

Interventions: Drug: Sevoflurane
Drug: Propofol
Drug: Xenon

First Posted Date: 2011-02-11

Last Posted Date: 2015-12-21

Lead Sponsor: Air Liquide Santé International

Target Recruit Count: 509

Registration Number: NCT01294163

Locations: 🇳🇱
Thorax Center - Erasmus MC, Rotterdam, Netherlands
🇩🇪
University Hospital Aachen, Aachen, Germany
🇫🇷
Hôpital Pontchaillou, Rennes, France

and more 14 locations