Memantine

Generic Name
Memantine
Brand Names
Axura, Ebixa, Marixino, Namenda, Namenda 49 Titration Pack, Namzaric, Nemdatine, Memantine Mylan, Memantine ratiopharm, Memantine Merz, Marixino (previously Maruxa), Memantine Accord, Memantine LEK
Drug Type
Small Molecule
Chemical Formula
C12H21N
CAS Number
19982-08-2
Unique Ingredient Identifier
W8O17SJF3T
Background

Initially approved by the FDA in 2013, memantine is an N-methyl-D-aspartate (NMDA) receptor antagonist used in the management of Alzheimer's Disease (AD). It is different from many other Alzheimer's Disease medications, as it works by a different mechanism than the cholinesterase enzyme inhibitors normally employed in the management of Alzheimer's disease . ...

Indication

Memantine is used to manage moderate to severe Alzheimer's dementia .
...

Associated Conditions
Alzheimer's Disease (AD), Moderate to Severe Alzheimer's Disease, Mild Vascular dementia, Moderate Alzheimer's Type Dementia, Moderate Vascular dementia, Severe Alzheimer's Type Dementia
Associated Therapies
-
Clinical Trials
Related News

An Open Label Trial of Memantine in the Treatment of Bulimia Nervosa and Body Dysmorphic Disorder

Not Applicable
Completed
Conditions
Bulimia Nervosa
Body Dysmorphic Disorder
Interventions
Drug: Memantine
First Posted Date
2009-12-23
Last Posted Date
2015-05-04
Lead Sponsor
Mclean Hospital
Target Recruit Count
5
Registration Number
NCT01038128
Locations
🇺🇸

McLean Hospital, Belmont, Massachusetts, United States

Memantine and Postoperative Pain

Phase 4
Terminated
Conditions
Pain
Interventions
Drug: Placebo
Drug: Memantine
First Posted Date
2009-12-15
Last Posted Date
2016-03-14
Lead Sponsor
Duke University
Target Recruit Count
77
Registration Number
NCT01032759
Locations
🇺🇸

Duke University, Durham, North Carolina, United States

Memantine Therapy in Amyotrophic Lateral Sclerosis

Phase 2
Completed
Conditions
Amyotrophic Lateral Sclerosis
Interventions
Drug: Memantine
First Posted Date
2009-11-25
Last Posted Date
2009-11-25
Lead Sponsor
Phoenix Neurological Associates, LTD
Target Recruit Count
20
Registration Number
NCT01020331
Locations
🇺🇸

Phoenix Neurological Associates, LTD, Phoenix, Arizona, United States

The Impact of Memantine on Electroconvulsive Therapy (ECT): Will it Improve Response and Protect Against Cognitive Problems?

Not Applicable
Withdrawn
Conditions
Major Depressive Disorder
Interventions
Drug: memantine
Drug: Placebo
First Posted Date
2009-10-02
Last Posted Date
2017-03-24
Lead Sponsor
Jerrry L Lewis
Registration Number
NCT00988663
Locations
🇺🇸

University of Iowa hosptitals and clinic, Iowa City, Iowa, United States

Efficacy and Safety of the Use of Memantine for Preserving Cognition in Adult Patients With Epilepsy

Not Applicable
Withdrawn
Conditions
Epilepsy
Interventions
Drug: Placebo
Drug: Memantine
First Posted Date
2009-09-29
Last Posted Date
2017-05-30
Lead Sponsor
University of California, Davis
Registration Number
NCT00986115
Locations
🇺🇸

University of California, Davis, Sacramento, California, United States

The Influence of Glutamate on Memory in Humans

Not Applicable
Completed
Conditions
Healthy Individuals
Interventions
Drug: Sugar pill
Drug: Glutamic Acid
Drug: Memantine
First Posted Date
2009-09-21
Last Posted Date
2014-12-03
Lead Sponsor
University Hospital, Bonn
Target Recruit Count
120
Registration Number
NCT00980408
Locations
🇩🇪

Forschungszentrum Juelich GmbH, Juelich, NRW, Germany

Memantine Augmentation in Treatment-Resistant Adults With Obsessive-Compulsive Disorder

Phase 2
Completed
Conditions
Obsessive-Compulsive Disorder
Interventions
Drug: Memantine
First Posted Date
2009-08-11
Last Posted Date
2017-06-21
Lead Sponsor
New York State Psychiatric Institute
Target Recruit Count
12
Registration Number
NCT00956085
Locations
🇺🇸

New York State Psychiatric Institute, New York, New York, United States

Effects of Memantine on Magnetic Resonance (MR) Spectroscopy in Subjects at Risk for Alzheimer's Disease

Phase 4
Completed
Conditions
Alzheimer's Disease
Interventions
Drug: memantine
Drug: Placebo
First Posted Date
2009-07-07
Last Posted Date
2014-10-21
Lead Sponsor
NYU Langone Health
Target Recruit Count
17
Registration Number
NCT00933608
Locations
🇺🇸

NYU School of Medicine, Dept. of Psychiatry, Center for Brain Health, New York, New York, United States

Cross-over Comparison of Gabapentin and Memantine as Treatment for Acquired Nystagmus

Not Applicable
Completed
Conditions
Nystagmus
Interventions
Drug: gabapentin
Drug: memantine
First Posted Date
2009-06-26
Last Posted Date
2016-07-29
Lead Sponsor
Case Western Reserve University
Target Recruit Count
10
Registration Number
NCT00928954
Locations
🇺🇸

Veterans Affairs Medical Center, 10701 East Boulevard, Cleveland, Ohio, United States

Memantine in the Treatment of Kleptomania

Phase 2
Completed
Conditions
Kleptomania
Interventions
Drug: Memantine
First Posted Date
2009-04-14
Last Posted Date
2021-05-24
Lead Sponsor
University of Chicago
Target Recruit Count
12
Registration Number
NCT00880685
Locations
🇺🇸

University of Minnesota, Minneapolis, Minnesota, United States

© Copyright 2024. All Rights Reserved by MedPath
HomeTerms & ConditionsPrivacy Policy