Nystatin

Generic Name: Nystatin

Brand Names: Flagystatin, Mycostatin, Nyaderm, Nyamyc, Nystop, Viaderm Kc

Drug Type: Small Molecule

Chemical Formula: C_₄₇H_₇₅NO_₁₇

CAS Number: 1400-61-9

Unique Ingredient Identifier: W1LX4T91WI

Background: Nystatin is a polyene antifungal drug that has broad-spectrum fungicidal and fungistatic activity against a number of yeasts and fungi, most notably Candida species. It is one of the most effective antifungal agents synthesized by bacteria, in this case a strain of Streptomyces noursei, and is closely related to amphotericin B, differing only slightly in str...

Indication: Nystatin is available in oral formulations for the treatment and/or prevention of oral candidiasis (a.k.a. thrush), intestinal candidiasis, and anal candidiasis. It is indicated topically for the treatment of vulvovaginal candidiasis and other cutaneous candida infections. A combination product containing nystatin alongside neomycin, gramicidin D, and triamc...

Associated Conditions: Anal candidiasis, Intestinal Candidiasis, Invasive Candidiasis, Mixed Vaginal Infections caused by Trichomonas Vaginalis, candida albicans, Oral Candidiasis, Pruritus Ani, Pruritus Vulvae, Skin candida, Trichomonas Vaginitis, Vaginal Candidiasis, Vulvovaginal Candidiasis, Corticosteroid-responsive dermatoses, Cutaneous candidiasis

Associated Therapies: -

Clinical Trials

Combination Immunosuppressive Therapy to Prevent Kidney Transplant Rejection in Adults

Phase 1

Completed

Conditions: Kidney Transplantation
Kidney Disease

Interventions: Drug: Alemtuzumab
Drug: Sirolimus
Drug: Tacrolimus
Procedure: Kidney transplant
Drug: Methylprednisolone (or equivalent)
Drug: Acetaminophen
Drug: Diphenhydramine
Drug: Trimethoprim (TMP)/Sulfa (Bactrim, Septra)
Drug: Valgancyclovir
Drug: Acyclovir
Drug: Pentamidine
Drug: Clotrimazole
Drug: Nystatin

First Posted Date: 2004-03-02

Last Posted Date: 2018-06-29

Lead Sponsor: University of Wisconsin, Madison

Target Recruit Count: 10

Registration Number: NCT00078559

Locations: 🇺🇸
University of Wisconsin - Department of Medicine, Madison, Wisconsin, United States

A Randomized, Double-Blind, Placebo Controlled Trial Evaluating the Impact of Nystatin on the Development of Oral Irritation in Patients Receiving High Dose Intravenous Interleukin-2

Phase 3

Completed

Conditions: Candidiasis, Oral
Gastrointestinal Diseases
Stomatitis

First Posted Date: 2002-12-10

Last Posted Date: 2008-03-04

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 84

Registration Number: NCT00001812

Locations: 🇺🇸
National Cancer Institute (NCI), Bethesda, Maryland, United States

A Study of Nystatin in HIV-Infected Patients

Phase 1

Completed

Conditions: HIV Infections

First Posted Date: 2001-08-31

Last Posted Date: 2005-06-24

Lead Sponsor: Argus Pharmaceuticals

Registration Number: NCT00002313

Locations: 🇺🇸
Twelve Oaks Hosp, Houston, Texas, United States

Comparative Randomized Study of the Efficacy, Safety, and Toleration of Fluconazole Oral Suspension or Nystatin Oral Suspension in the Treatment of Patients With Oropharyngeal Candidiasis in Association With the Acquired Immunodeficiency Syndrome

Not Applicable

Completed

Conditions: Candidiasis, Oral
HIV Infections

First Posted Date: 2001-08-31

Last Posted Date: 2005-06-24

Lead Sponsor: Pfizer

Registration Number: NCT00002112

Locations: 🇺🇸
California Med Research Group, Fresno, California, United States
🇺🇸
UCSF Hosp, San Francisco, California, United States
🇺🇸
Johns Hopkins School of Medicine, Baltimore, Maryland, United States

and more 2 locations

A Phase I/II Clinical Study of Nystatin I.V. (Intravenous) in Patients With HIV Infection.

Phase 1

Completed

Conditions: HIV Infections

First Posted Date: 2001-08-31

Last Posted Date: 2005-06-24

Lead Sponsor: Argus Pharmaceuticals

Registration Number: NCT00002097

Locations: 🇺🇸
Twelve Oaks Hosp, Houston, Texas, United States

Pharmacokinetics of Nystatin LF I.V. in Patients With Acquired Immune Deficiency Syndrome-Related Complex (ARC)

Not Applicable

Completed

Conditions: HIV Infections

First Posted Date: 2001-08-31

Last Posted Date: 2005-06-24

Lead Sponsor: Argus Pharmaceuticals

Registration Number: NCT00001998

Locations: 🇺🇸
Twelve Oaks Hosp, Houston, Texas, United States

Nystatin Pastilles for the Prevention of Oral Candidiasis in Patients With AIDS or ARC

Not Applicable

Completed

Conditions: Candidiasis, Oral
HIV Infections

First Posted Date: 2001-08-31

Last Posted Date: 2007-10-02

Lead Sponsor: Bristol-Myers Squibb

Registration Number: NCT00002057

Locations: 🇺🇸
Birmingham Veterans Administration Med Ctr / Univ of Alabama, Birmingham, Alabama, United States
🇺🇸
Bristol - Myers Squibb Co, Princeton, New Jersey, United States

A Study of Nystatin in the Prevention of Fungal Infections of the Mouth in Patients With AIDS or AIDS-Related Syndromes

Not Applicable

Completed

Conditions: Candidiasis, Oral
HIV Infections

First Posted Date: 2001-08-31

Last Posted Date: 2007-10-02

Lead Sponsor: Bristol-Myers Squibb

Registration Number: NCT00002293

Locations: 🇺🇸
Birmingham Veterans Administration Med Ctr / Univ of Alabama, Birmingham, Alabama, United States
🇺🇸
Bristol - Myers Squibb Co, Princeton, New Jersey, United States

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