Nitric Oxide
- Generic Name
- Nitric Oxide
- Brand Names
- Inomax, Kinox, Noxivent, INOmax
- Drug Type
- Small Molecule
- Chemical Formula
- NO
- CAS Number
- 10102-43-9
- Unique Ingredient Identifier
- 31C4KY9ESH
- Background
Nitric oxide or Nitrogen monoxide is a chemical compound with chemical formula NO. This gas is an important signaling molecule in the body of mammals including humans and is an extremely important intermediate in the chemical industry. It is also a toxic air pollutant produced by automobile engines and power plants.
Nitric oxide (NO) should not be confused with nitrous oxide (N2O), a general anaesthetic, or with nitrogen dioxide (NO2) which is another poisonous air pollutant.
The nitric oxide molecule is a free radical, which is relevant to understanding its high reactivity. It reacts with the ozone in air to form nitrogen dioxide, signalled by the appearance of the reddish-brown color.
- Indication
For the treatment of term and near-term (>34 weeks) neonates with hypoxic respiratory failure
- Associated Conditions
- Hypoxic Respiratory Failure
- Associated Therapies
- -
Inhaled Nitric Oxide for Pediatric Painful Sickle Crisis
- First Posted Date
- 2005-09-02
- Last Posted Date
- 2023-02-23
- Lead Sponsor
- Boston Children's Hospital
- Target Recruit Count
- 18
- Registration Number
- NCT00142051
- Locations
- 🇺🇸
Children's Hospital Boston, Boston, Massachusetts, United States
Nitric Oxide Inhalation to Treat Sickle Cell Pain Crises
- First Posted Date
- 2004-10-28
- Last Posted Date
- 2020-02-05
- Lead Sponsor
- Mallinckrodt
- Target Recruit Count
- 150
- Registration Number
- NCT00094887
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States
🇺🇸Johns Hopkins University, Baltimore, Maryland, United States
🇺🇸Colorado Sickle Cell Treatement and Research Center, Aurora, Colorado, United States
The Effects of Nitric Oxide for Inhalation During Left Ventricular Assists Device (LVAD) Implantation
- First Posted Date
- 2003-05-15
- Last Posted Date
- 2016-08-22
- Lead Sponsor
- Mallinckrodt
- Target Recruit Count
- 150
- Registration Number
- NCT00060840
- Locations
- 🇬🇧
Harefield Hospital, Harefield, Middlesex, United Kingdom
🇺🇸Duke University Medical Center, Durham, North Carolina, United States
🇺🇸Cleveland Clinic Foundation, Cleveland, Ohio, United States
Nitric Oxide and Transfusion Therapy for Sickle Cell Patients With Pulmonary Hypertension
- Conditions
- Pulmonary HypertensionSickle Cell Anemia
- First Posted Date
- 2001-09-03
- Last Posted Date
- 2019-12-17
- Lead Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
- Target Recruit Count
- 59
- Registration Number
- NCT00023296
- Locations
- 🇺🇸
Suburban Hospital, Bethesda, Maryland, United States
🇺🇸National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States
Effects of Nitric Oxide and Nitroglycerin in Patients With Sickle Cell Anemia
- Conditions
- Chest PainSickle Cell Anemia
- First Posted Date
- 1999-11-04
- Last Posted Date
- 2008-03-04
- Lead Sponsor
- National Institutes of Health Clinical Center (CC)
- Target Recruit Count
- 58
- Registration Number
- NCT00001716
- Locations
- 🇺🇸
Warren G. Magnuson Clinical Center (CC), Bethesda, Maryland, United States
Drug Development Updates
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