Oxytocin

Generic Name
Oxytocin
Brand Names
Pitocin
Drug Type
Biotech
Chemical Formula
-
CAS Number
50-56-6
Unique Ingredient Identifier
1JQS135EYN
Background

Sir Henry H. Dale first identified oxytocin and its uterine contractile properties in 1906. Like all other neurohypophysial hormones, oxytocin is composed of nine amino acids with a disulfide bridge between the Cys 1 and 6 residues. In the mid-1950s, synthetic oxytocin was successfully synthesized by a biochemist named Vincent du Vigneaud; he was later recog...

Indication

Administration of exogenous oxytocin is indicated in the antepartum period to initiate or improve uterine contractions for vaginal delivery in situations where there is fetal or maternal concern. For example, It may be used to induce labor in cases of Rh sensitization, maternal diabetes, preeclampsia at or near term, and when delivery is indicated due to pre...

Associated Conditions
Incomplete Abortion, Inevitable abortion, Postpartum Bleeding
Associated Therapies
Reinforcement of labor
Clinical Trials
Related News

Oxytocin to Treat PTSD

Phase 2
Recruiting
Conditions
PTSD
Interventions
Drug: Oxytocin
Other: Placebo
First Posted Date
2020-01-14
Last Posted Date
2024-07-15
Lead Sponsor
VA Office of Research and Development
Target Recruit Count
188
Registration Number
NCT04228289
Locations
🇺🇸

San Francisco VA Medical Center, San Francisco, CA, San Francisco, California, United States

🇺🇸

Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston, South Carolina, United States

High Dose Oxytocin Nasal Spray for Treatment of Tinnitus

Phase 3
Terminated
Conditions
Tinnitus
Interventions
Other: Placebo nasal spray
Drug: Oxytocin
First Posted Date
2019-12-24
Last Posted Date
2022-10-05
Lead Sponsor
NYU Langone Health
Target Recruit Count
33
Registration Number
NCT04210310
Locations
🇺🇸

222 East 41st Street Ambulatory Care Center, Preston Robert Tisch Center for Men's Health, New York, New York, United States

EMG for Uterotonic Efficiency Estimation

Not Applicable
Completed
Conditions
Postpartum Hemorrhage
Interventions
Drug: Carbetocin
Drug: Oxytocin
First Posted Date
2019-12-17
Last Posted Date
2022-06-27
Lead Sponsor
University Medical Centre Ljubljana
Target Recruit Count
60
Registration Number
NCT04201665
Locations
🇸🇮

UMC Ljubljana, Ljubljana, Slovenia

Neurobiological Effects of Oxytocin in Schizophrenia

Not Applicable
Conditions
Schizophrenia
Interventions
Drug: Placebo
Drug: Oxytocin
First Posted Date
2019-11-26
Last Posted Date
2021-08-31
Lead Sponsor
National Institute of Mental Health and Neuro Sciences, India
Target Recruit Count
44
Registration Number
NCT04177719
Locations
🇮🇳

National Institute of Mental Health and Neurosciecnes, Bangalore, Karnataka, India

Neurobiological Effects of Oxytocin in Schizophrenia - Imaging Study

Not Applicable
Completed
Conditions
Schizophrenia
Interventions
Drug: oxytocin
First Posted Date
2019-11-08
Last Posted Date
2019-11-08
Lead Sponsor
National Institute of Mental Health and Neuro Sciences, India
Target Recruit Count
90
Registration Number
NCT04158167
Locations
🇮🇳

National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India

Labor Induction With Misoprostol Versus Oxytocin in Women With Premature Rupture of Membranes

First Posted Date
2019-10-29
Last Posted Date
2020-01-29
Lead Sponsor
sammour.rami
Target Recruit Count
200
Registration Number
NCT04143685
Locations
🇮🇱

Bnai Zion Medical Center, Haifa, Israel

Tranexamic Acid Versus Sublingual Misoprostol in Reducing Blood Loss During Elective CS in High Risk Cases

First Posted Date
2019-10-07
Last Posted Date
2020-01-31
Lead Sponsor
Cairo University
Target Recruit Count
345
Registration Number
NCT04117243
Locations
🇪🇬

Faculty of Medicine, Cairo, Egypt

Effects of Oxytocin on Hemodynamics in Patients Undergoing Laparoscopic Myomectomy

First Posted Date
2019-09-30
Last Posted Date
2019-09-30
Lead Sponsor
Yangzhou University
Target Recruit Count
80
Registration Number
NCT04109339
Locations
🇨🇳

the Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, China

Oxytocin Effects on the Prosocial Learning

Not Applicable
Completed
Conditions
Healthy
Interventions
Drug: Oxytocin
Drug: Placebo
First Posted Date
2019-09-26
Last Posted Date
2019-09-26
Lead Sponsor
University of Electronic Science and Technology of China
Target Recruit Count
90
Registration Number
NCT04105140
Locations
🇨🇳

School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, China

Effects of Intramuscular (IM) Oxytocin on Pupil Diameter and Heart Rate Variability (HRV)

Phase 4
Completed
Conditions
Chronic Pain Due to Injury
Interventions
Drug: Oxytocin
Drug: Placebo
First Posted Date
2019-09-26
Last Posted Date
2022-11-10
Lead Sponsor
Wake Forest University Health Sciences
Target Recruit Count
22
Registration Number
NCT04105998
Locations
🇺🇸

Wake Forest Baptist Health, Winston-Salem, North Carolina, United States

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