Oxytocin

Generic Name
Oxytocin
Brand Names
Pitocin
Drug Type
Biotech
Chemical Formula
-
CAS Number
50-56-6
Unique Ingredient Identifier
1JQS135EYN
Background

Sir Henry H. Dale first identified oxytocin and its uterine contractile properties in 1906. Like all other neurohypophysial hormones, oxytocin is composed of nine amino acids with a disulfide bridge between the Cys 1 and 6 residues. In the mid-1950s, synthetic oxytocin was successfully synthesized by a biochemist named Vincent du Vigneaud; he was later recog...

Indication

Administration of exogenous oxytocin is indicated in the antepartum period to initiate or improve uterine contractions for vaginal delivery in situations where there is fetal or maternal concern. For example, It may be used to induce labor in cases of Rh sensitization, maternal diabetes, preeclampsia at or near term, and when delivery is indicated due to pre...

Associated Conditions
Incomplete Abortion, Inevitable abortion, Postpartum Bleeding
Associated Therapies
Reinforcement of labor
Clinical Trials
Related News

Carbetocin Versus Oxytocin for Prevention of Postcesarean Hemorrhage in Pregnancy With High Risk for PPH

First Posted Date
2019-09-13
Last Posted Date
2019-09-13
Lead Sponsor
Rajavithi Hospital
Target Recruit Count
120
Registration Number
NCT04089176
Locations
🇹🇭

Rajavithi Hospital, Bangkok, Thailand

qMOLI- A Qualitative Assessment of Misoprostol or Oxytocin for Labour Induction

First Posted Date
2019-07-30
Last Posted Date
2022-02-11
Lead Sponsor
University of Liverpool
Target Recruit Count
136
Registration Number
NCT04037683
Locations
🇮🇳

Government Medical College, Nagpur, Maharashtra, India

Pitocin or Oral Misoprostol for PROM IOL

Phase 4
Completed
Conditions
PROM
Interventions
Drug: Misoprostol
Drug: Oxytocin
First Posted Date
2019-07-23
Last Posted Date
2024-04-30
Lead Sponsor
University of Pennsylvania
Target Recruit Count
108
Registration Number
NCT04028765
Locations
🇺🇸

Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United States

Oxytocin at Elective Cesarean Deliveries: A Dose-finding Study in Women With Twin Pregnancy

Not Applicable
Completed
Conditions
Twin
Postpartum Hemorrhage
Interventions
Drug: Oxytocin
First Posted Date
2019-07-19
Last Posted Date
2022-01-28
Lead Sponsor
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Target Recruit Count
30
Registration Number
NCT04025658
Locations
🇨🇦

Mount Sinai Hospital, Toronto, Ontario, Canada

Continuous Versus Intermittent Oxytocin Infusion for Induction of Labor

Not Applicable
Completed
Conditions
Induced; Birth
Interventions
Drug: Oxytocin
First Posted Date
2019-07-12
Last Posted Date
2023-09-13
Lead Sponsor
Rambam Health Care Campus
Target Recruit Count
153
Registration Number
NCT04017247
Locations
🇮🇱

Rambam health care campus, Haifa, Israel

Labor Protocol Study

First Posted Date
2019-07-02
Last Posted Date
2022-10-04
Lead Sponsor
Montefiore Medical Center
Target Recruit Count
66
Registration Number
NCT04004845
Locations
🇺🇸

Montefiore Medical Center Weiler Division / Albert Einstein College of Medicine, Bronx, New York, United States

Oxytocin at Elective Cesarean Deliveries: A Dose-finding Study in Women With BMI ≥ 40kg/m2

Not Applicable
Completed
Conditions
Postpartum Hemorrhage
Obesity
Interventions
Drug: Oxytocin
First Posted Date
2019-05-21
Last Posted Date
2020-02-06
Lead Sponsor
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Target Recruit Count
30
Registration Number
NCT03957083
Locations
🇨🇦

Mount Sinai Hospital, Toronto, Ontario, Canada

Effects of Oxytocin and Carbetocin on Renal System in Cesarean Sections

First Posted Date
2019-05-07
Last Posted Date
2019-05-13
Lead Sponsor
Ufuk University
Target Recruit Count
100
Registration Number
NCT03939806
Locations
🇹🇷

Ufuk University Faculty of Medicine Hospital, Ankara, Balgat, Turkey

Oxytocin in MRI-HIFU

Phase 4
Conditions
Fibroid
Adenomyosis
Interventions
Drug: Oxytocin
First Posted Date
2019-05-03
Last Posted Date
2019-05-03
Lead Sponsor
Turku University Hospital
Target Recruit Count
100
Registration Number
NCT03937401
Locations
🇫🇮

Turku University Hospital, Turku, Finland

Effects of Intramuscular Oxytocin on Sensory Function in Healthy Volunteers With Ultraviolet Burn Injury to the Skin

Phase 4
Completed
Conditions
Chronic Pain
Interventions
Drug: Oxytocin
Drug: Saline
First Posted Date
2019-05-02
Last Posted Date
2021-04-05
Lead Sponsor
Wake Forest University Health Sciences
Target Recruit Count
10
Registration Number
NCT03935399
Locations
🇺🇸

Wake Forest Baptist Health, Winston-Salem, North Carolina, United States

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