Doxycycline

Generic Name: Doxycycline

Brand Names: Acticlate, Adoxa, Apprilon, Atridox, Doryx, Doxy, Doxycin, Lymepak, Mondoxyne, Monodox, Morgidox, Okebo, Oracea, Periostat, Targadox, Vibramycin

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₄N_₂O_₈

CAS Number: 564-25-0

Unique Ingredient Identifier: 334895S862

Background: Doxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and gram-negative bacterial infections. It is also used to treat acne and malaria.

Indication: Doxycycline is indicated for the treatment of various infections by gram-positive and gram-negative bacteria, aerobes and anaerobes, as well other types of bacteria, including:

It is also used to treat infections caused by the following gram-negative microorganisms:

Associated Conditions: Acinetobacter Infections, Anthrax, Bacterial Infection caused by Enterobacter aerogenes, Bartonellosis, Brucellosis, Campylobacter Infection, Chancroid, Chlamydia Trachomatis Infection, Early Lyme Disease, Granuloma Inguinale, Infection Due to Escherichia Coli, Inhalational Anthrax, Klebsiella Infections, Lymphogranuloma Venereum, Malaria caused by Plasmodium falciparum, Nongonococcal urethritis, Plague caused by Yersinia pestis, Psittacosis, Rectal infection caused by Chlamydia Trachomatis, Relapsing fever caused by Borrelia recurrentis, Respiratory Tract Infection Bacterial, Rickettsial infectious disorders, Severe Acne, Sexually Transmitted Infections (STIs), Shigella Infection, Trachoma inclusion conjunctivitis, Tularemia, Vibrio Cholerae Infection, Acute Intestinal amebiasis, Susceptible Bacterial Infections, Uncomplicated endocervical infection, Uncomplicated urethral infection

Clinical Trials

A Clinical Trial to Determine the Effects of 40 Mg Doxycycline Versus a Placebo Control for the Treatment of Rosacea

Phase 3

Completed

Conditions: Rosacea

First Posted Date: 2005-08-04

Last Posted Date: 2005-08-19

Lead Sponsor: CollaGenex Pharmaceuticals

Target Recruit Count: 528

Registration Number: NCT00126399

Adjunctive Treatment With Doxycycline to Enhance the Durability of Endovascular Aortic Aneurysm Repair

Not Applicable

Completed

Conditions: Aortic Aneurysm

First Posted Date: 2005-08-03

Last Posted Date: 2010-03-04

Lead Sponsor: The Foundation for Barnes-Jewish Hospital

Target Recruit Count: 75

Registration Number: NCT00126204

Locations: 🇺🇸
Washington University School of Medicine / Barnes-Jewish Hospital, St. Louis, Missouri, United States

Bleomycin, Doxycycline, or Talc in Treating Patients With Malignant Pleural Effusions

Phase 3

Completed

Conditions: Metastatic Cancer

First Posted Date: 2004-09-02

Last Posted Date: 2023-06-22

Lead Sponsor: Eastern Cooperative Oncology Group

Target Recruit Count: 480

Registration Number: NCT00002872

Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers

Phase 2

Completed

Conditions: Periodontitis
Periodontal Diseases

Interventions: Procedure: Scaling and root planing
Drug: Metronidazole
Drug: Amoxicillin
Drug: Doxycycline

First Posted Date: 2003-08-05

Last Posted Date: 2013-04-22

Lead Sponsor: The Forsyth Institute

Target Recruit Count: 146

Registration Number: NCT00066066

Locations: 🇺🇸
Department of Periodontology, Cambridge, Massachusetts, United States

Norplant and Irregular Bleeding/Spotting

Phase 4

Conditions: Endometrial Bleeding
Periodontal Disease

First Posted Date: 2003-07-15

Last Posted Date: 2005-06-24

Lead Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Target Recruit Count: 50

Registration Number: NCT00064766

Locations: 🇺🇸
CONRAD Clinical Research Center, Eastern Virginia Medical School, Norfolk, Virginia, United States

Determine the Effect of Administering Periostat(R) Twice Daily on Patients With Acne Rosacea

Phase 3

Completed

Conditions: Acne Rosacea

First Posted Date: 2002-07-23

Last Posted Date: 2005-06-24

Lead Sponsor: CollaGenex Pharmaceuticals

Target Recruit Count: 150

Registration Number: NCT00041977

Locations: 🇺🇸
Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States
🇺🇸
David Pariser, MD, Norfolk, Virginia, United States
🇺🇸
Beer and Houck/Florida Dermatology Institute, West Palm Beach, Florida, United States

and more 4 locations

Azithromycin/Bicillin Syphilis

Phase 3

Completed

Conditions: Syphilis

Interventions: Drug: Azithromycin
Drug: Benzathine Penicillin
Drug: Doxycycline

First Posted Date: 2002-03-07

Last Posted Date: 2013-04-29

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 593

Registration Number: NCT00031499

Locations: 🇺🇸
Louisiana State University Health Sciences Center - Infectious Diseases, New Orleans, Louisiana, United States
🇲🇬
Hopitaly Mahabibo, Mahajanga Majunga, Mahajanga, Madagascar
🇺🇸
University of Alabama Hospital - Infectious Diseases, Birmingham, Alabama, United States

and more 7 locations