Cephalexin

Generic Name: Cephalexin

Brand Names: Keflex

Drug Type: Small Molecule

Chemical Formula: C_₁₆H_₁₇N_₃O_₄S

CAS Number: 15686-71-2

Unique Ingredient Identifier: 5SFF1W6677

Background: Cephalexin is the first of the first generation cephalosporins. This antibiotic contains a beta lactam and a dihydrothiazide. Cephalexin is used to treat a number of susceptible bacterial infections through inhibition of cell wall synthesis. Cephalexin was approved by the FDA on 4 January 1971.

Indication: Cephalexin is indicated for the treatment of certain infections caused by susceptible bacteria. These infections include respiratory tract infections, otitis media, skin and skin structure infections, bone infections, and genitourinary tract infections.

Associated Conditions: Bone Infection, Genitourinary tract infection, Otitis Media (OM), Respiratory Tract Infections (RTI), Skin and skin structure infections, Acute Prostatitis

Associated Therapies: -

Clinical Trials

High-dose vs. Standard-dose Cephalexin for Cellulitis

Phase 4

Completed

Conditions: Cellulitis

Interventions: Drug: Cephalexin

First Posted Date: 2020-07-15

Last Posted Date: 2022-05-02

Lead Sponsor: Ottawa Hospital Research Institute

Target Recruit Count: 66

Registration Number: NCT04471246

Locations: 🇨🇦
The Ottawa Hospital, Ottawa, Ontario, Canada

Antibiotic Prophylaxis in High-Risk Arthroplasty Patients

Phase 4

Conditions: Inflammatory Disease
Tobacco Use
Infections Joint Prosthetic
Overweight or Obesity
Autoimmune Diseases
MSSA Colonization
MRSA
Chronic Kidney Diseases
Diabetes

Interventions: Drug: Cephalexin
Drug: Doxycycline
Drug: Cefadroxil

First Posted Date: 2020-03-05

Last Posted Date: 2024-06-27

Lead Sponsor: Mayo Clinic

Target Recruit Count: 4618

Registration Number: NCT04297592

Locations: 🇺🇸
Mayo Clinic, Rochester, Minnesota, United States
🇺🇸
University of Iowa Hospitals & Clinics, Iowa City, Iowa, United States

Cefadroxil and Cephalexin Drug Levels and Dosing in Pediatric Musculoskeletal Infections

Phase 1

Completed

Conditions: Septic Arthritis
Osteomyelitis
Pyomyositis

Interventions: Drug: Cefadroxil
Drug: Cephalexin

First Posted Date: 2019-01-14

Last Posted Date: 2021-06-02

Lead Sponsor: University of Colorado, Denver

Target Recruit Count: 17

Registration Number: NCT03802552

Locations: 🇺🇸
Children's Hospital Colorado, Aurora, Colorado, United States

Antibiotics for Prevention of SSI in Obese Women Undergoing CS

Not Applicable

Conditions: Surgical Site Infection

Interventions: Drug: Cephalexin

First Posted Date: 2018-11-09

Last Posted Date: 2018-11-09

Lead Sponsor: Ain Shams University

Target Recruit Count: 280

Registration Number: NCT03736187

The Effect of Prophylactic Antibiotics on Surgical Site Infection Lower Limb Skin Excisions

Not Applicable

Withdrawn

Conditions: Skin Lesion

Interventions: Drug: Cephalexin
Drug: Placebo oral capsule

First Posted Date: 2017-11-29

Last Posted Date: 2022-05-04

Lead Sponsor: Rambam Health Care Campus

Registration Number: NCT03357419

Locations: 🇮🇱
Department of Plastic Surgery, Rambam Medical Center, Haifa, Israel

Prophylactic Antibiotics After Cesarean

Phase 1

Completed

Conditions: Surgical Site Infection

Interventions: Drug: Cephalexin
Drug: Placebo
Drug: Metronidazole

First Posted Date: 2017-06-14

Last Posted Date: 2023-08-16

Lead Sponsor: The University of Texas Medical Branch, Galveston

Target Recruit Count: 321

Registration Number: NCT03187106

Locations: 🇺🇸
St. David's North Austin Medical Center, Austin, Texas, United States
🇺🇸
University of Texas Medical Branch John Sealy Hospital, Galveston, Texas, United States

Treatment of Asymptomatic Bacteriuria in Pregnancy

Not Applicable

Terminated

Conditions: Bacteriuria (Asymptomatic) in Pregnancy

Interventions: Drug: Cephalexin
Drug: Nitrofurantoin

First Posted Date: 2016-09-22

Last Posted Date: 2018-04-18

Lead Sponsor: Saint Joseph Mercy Health System

Target Recruit Count: 13

Registration Number: NCT02911662

Locations: 🇺🇸
St. Joseph Mercy Hospital, Ypsilanti, Michigan, United States

Antibiotics After Breast Reduction:Clinical Trial With Randomization

Phase 2

Completed

Conditions: Surgical Site Infection

Interventions: Drug: Placebo
Drug: Cephalexin

First Posted Date: 2015-10-07

Last Posted Date: 2018-04-20

Lead Sponsor: Federal University of São Paulo

Target Recruit Count: 124

Registration Number: NCT02569866

Locations: 🇧🇷
Hospital das Clínicas Samuel Libanio, Pouso Alegre, Minas Gerais, Brazil

A Study of Cephalexin Liquid in Healthy Participants

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Cephalexin

First Posted Date: 2015-07-07

Last Posted Date: 2016-10-26

Lead Sponsor: Eli Lilly and Company

Target Recruit Count: 28

Registration Number: NCT02490670

Locations: 🇲🇽
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Mexico City, Mexico

A Study of Cephalexin Liquid for Pediatrics in Healthy Adults Participants

Phase 1

Completed

Conditions: Healthy Volunteers

Interventions: Drug: Cephalexin

First Posted Date: 2014-04-25

Last Posted Date: 2015-06-25

Lead Sponsor: Eli Lilly and Company

Target Recruit Count: 28

Registration Number: NCT02123472

Locations: 🇲🇽
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Mexico City, Mexico

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