MedPath

Coenzyme Q10

Generic Name
Coenzyme Q10
Drug Type
Small Molecule
Chemical Formula
C59H90O4
CAS Number
303-98-0
Unique Ingredient Identifier
EJ27X76M46
Background

Ubidecarenone, also called coenzyme Q10, is a 1,4-benzoquinone. From its name (Q10), the Q refers to the constitutive quinone group, and 10 is related to the number of isoprenyl subunits in its tail. It is a powerful antioxidant, a lipid-soluble and essential cofactor in mitochondrial oxidative phosphorylation. The ubidecarenone is the coenzyme destined for mitochondrial enzyme complexes involved in oxidative phosphorylation in the production of ATP. It is fundamental for cells that have a high metabolic demand. Ubidecarenone is sold as a dietary supplement and is not FDA approved as a drug - it is not meant to treat, cure or prevent any disease. FDA does not approve this dietary supplements before sold nor regulate the manufacturing process.

Indication

The diet supplements containing ubidecarenone are indicated, as stated in the product label, to assist individuals with cardiovascular complaints including congestive heart failure and systolic hypertension. In the product, ubidecarenone is used to increase the cardiac input as well as for the prevention of several other diseases like Parkinson, fibromyalgia, migraine, periodontal disease and diabetes, based on preclinical studies. It is important to highlight that these products are not FDA approved and it is recommended to use under discretion.

Associated Conditions
Migraine

A Study of BPM31510 With Vitamin K1 in Subjects With Newly Diagnosed Glioblastoma (GB)

Phase 2
Recruiting
Conditions
Glioblastoma
Glioblastoma Multiforme
Interventions
Other: Vitamin K1
Radiation: Radiation
First Posted Date
2021-02-12
Last Posted Date
2025-04-06
Lead Sponsor
BPGbio
Target Recruit Count
50
Registration Number
NCT04752813
Locations
🇺🇸

Sansum Clinic, Santa Barbara, California, United States

🇺🇸

Dana Farber Cancer Institute, Boston, Massachusetts, United States

🇺🇸

UT Health San Antonio Mays Cancer Center, San Antonio, Texas, United States

and more 10 locations

Protective Effect of CoQ10 Against Negative Inflammatory Response and Organ Dysfunction in Cardiovascular Surgery (PANDA V)

Not Applicable
Recruiting
Conditions
Cardiovascular Disease
Interventions
Dietary Supplement: Standard Medical Therapy
First Posted Date
2020-06-23
Last Posted Date
2024-11-27
Lead Sponsor
Nanjing Medical University
Target Recruit Count
500
Registration Number
NCT04444349
Locations
🇨🇳

West China Hospital of Sichuan University, Chengdu, Sichuan, China

🇨🇳

Beijing Anzhen Hospital, Beijing, Beijing, China

🇨🇳

The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China

and more 1 locations

Coenzyme q 10 and Fertility Outcome in Women With Clomiphene Resistant PCOS

Phase 4
Completed
Conditions
Coenzyme q10
Interventions
First Posted Date
2020-03-10
Last Posted Date
2020-11-25
Lead Sponsor
Karachi Medical and Dental College
Target Recruit Count
149
Registration Number
NCT04302532
Locations
🇵🇰

Aziz medical center, Karachi, Sindh, Pakistan

Coenzyme Q10 and Meclofenoxate in Hepatic Encephalopathy

Not Applicable
Conditions
Coenzyme Q10
Intellectual Functioning Disability
Hepatic Encephalopathy
Interventions
First Posted Date
2019-05-23
Last Posted Date
2019-07-18
Lead Sponsor
Zagazig University
Target Recruit Count
300
Registration Number
NCT03961087
Locations
🇪🇬

Amr Shaaban Hanafy, Zagazig, Alsharkia, Egypt

Anti-oxidant Therapy and Postoperative Cardiac Events (ACE) Trial, Preoperative Intervention in Vascular Surgery

Early Phase 1
Conditions
Myocardial Injury
Interventions
Drug: Placebo
First Posted Date
2019-05-20
Last Posted Date
2021-08-31
Lead Sponsor
Minneapolis Veterans Affairs Medical Center
Target Recruit Count
341
Registration Number
NCT03956017
Locations
🇺🇸

Va Medical Center, Minneapolis, Minnesota, United States

CoQ10 and D-ribose in Patients With Diastolic Heart Failure

Phase 2
Completed
Conditions
Heart Failure, Diastolic
Interventions
Other: Placebo pills
Other: Placebo powder
First Posted Date
2017-04-28
Last Posted Date
2022-03-18
Lead Sponsor
University of Kansas Medical Center
Target Recruit Count
216
Registration Number
NCT03133793
Locations
🇺🇸

University of Kansas Medical Center, Kansas City, Kansas, United States

Neotililty Trial: Effect of Coenzyme Q10 on Semen Parameters in Men With Idiopathic Infertility

Phase 4
Withdrawn
Conditions
Idiopathic Infertility
Interventions
First Posted Date
2017-04-07
Last Posted Date
2018-09-17
Lead Sponsor
PharmEvo Pvt Ltd
Registration Number
NCT03104998
Locations
🇵🇰

HillPark Hospital, Karachi, Pakistan

BPM31510 in Treating Patients With Recurrent High-Grade Glioma Previously Treated With Bevacizumab

Phase 1
Completed
Conditions
Astrocytoma of Brain
Gliosarcoma
Glioblastoma
Recurrent Glioblastoma
Interventions
Other: Laboratory Biomarker Analysis
Other: Pharmacological Study
First Posted Date
2017-01-13
Last Posted Date
2021-08-10
Lead Sponsor
Seema Nagpal
Target Recruit Count
12
Registration Number
NCT03020602
Locations
🇺🇸

Stanford University, School of Medicine, Palo Alto, California, United States

Immediate or Delayed Naturopathic Medicine in Combination With Neo-Adjuvant Chemotherapy for Breast Cancer

Phase 1
Terminated
Conditions
Quality of Life
Interventions
Biological: Reishi mushroom extract
First Posted Date
2015-07-01
Last Posted Date
2018-08-01
Lead Sponsor
Midwestern Regional Medical Center
Target Recruit Count
5
Registration Number
NCT02486796

Beneficial Effects of Coenzyme Q10 Treatment on the Mitochondrial Dysfunction and Oxidative Stress Associated to Atherothrombosis Developement in Antiphospholipidid Syndrome Patients

Not Applicable
Conditions
Coenzyme Q10 on Athero-thrombosis in APS Patients
Interventions
Drug: Placebo
First Posted Date
2014-08-18
Last Posted Date
2014-08-18
Lead Sponsor
Maimónides Biomedical Research Institute of Córdoba
Target Recruit Count
50
Registration Number
NCT02218476
Locations
🇪🇸

Hospital Universitario Reina Sofía de Córdoba, Cordoba, Andalucía, Spain

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