Dorzolamide
- Generic Name
- Dorzolamide
- Brand Names
- Cosopt, Trusopt
- Drug Type
- Small Molecule
- Chemical Formula
- C10H16N2O4S3
- CAS Number
- 120279-96-1
- Unique Ingredient Identifier
- 9JDX055TW1
- Background
Dorzolamide is a non-bacteriostatic sulfonamide derivative and topical carbonic anhydrase (CA) inhibitor that treats elevated intraocular pressure (IOP) associated with open-angle glaucoma and ocular hypertension. It works by blocking an enzyme in the ciliary process that regulates ion balance and fluid pressure in the eyes. Unlike oral CA inhibitors, dorzolamide has negligible effects of acid-base or electrolyte disturbances and other systemic adverse effects. First marketed in 1995, dorzolamide is available in ophthalmic solutions as monotherapy marketed as Trusopt or in combination with timolol as Cosopt PF.
- Indication
Dorzolamide is indicated for the management of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. It can also be used in combination with timolol for the same indication in patients who are insufficiently responsive to ophthalmic beta-blockers.
Its pre-operative use was also investigated to prevent elevated intraocular pressure after neodynium yttrium aluminum garnet laser posterior capsulotomy.
- Associated Conditions
- Increased Intra Ocular Pressure (IOP), Ocular Hypertension
A Study to Evaluate the Effectiveness of Cosopt® as First Line Therapy (MK-0507A-153)
- Conditions
- Ocular HypertensionGlaucoma
- Interventions
- First Posted Date
- 2007-10-18
- Last Posted Date
- 2017-04-04
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 170
- Registration Number
- NCT00546286
Dry Eye Study With Cosopt® Over 8 Weeks in Patients With Open-Angle Glaucoma or Ocular Hypertension (0507A-152)(COMPLETED)
- Conditions
- Ocular HypertensionOpen Angle Glaucoma
- First Posted Date
- 2007-10-17
- Last Posted Date
- 2017-06-20
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 176
- Registration Number
- NCT00545064
A Phase IV Study of Travoprost + Brinzolamide to Treat Glaucoma or Ocular Hypertension
- Conditions
- GlaucomaOcular Hypertension
- Interventions
- First Posted Date
- 2007-05-09
- Last Posted Date
- 2010-03-16
- Lead Sponsor
- Alcon Research
- Target Recruit Count
- 46
- Registration Number
- NCT00471380
- Locations
- 🇮🇹
Catania, Catania, Italy
Study of Travatan and Cosopt in Primary Open-Angle Glaucoma or Ocular Hypertension
- Conditions
- Open-angle GlaucomaOcular Hypertension
- Interventions
- First Posted Date
- 2007-05-09
- Last Posted Date
- 2012-04-11
- Lead Sponsor
- Alcon Research
- Target Recruit Count
- 46
- Registration Number
- NCT00471068
- Locations
- 🇵🇹
Coimbra, Coimbra, Portugal
MK0507A Clinical Study in Patients With Glaucoma and Ocular Hypertension (0507A-149)(COMPLETED)
- First Posted Date
- 2007-03-21
- Last Posted Date
- 2017-06-20
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 474
- Registration Number
- NCT00449956
Comparison of Efficacy of Two Groups of Glaucoma Drops (Xalatan vs.Cosopt) in Reducing Eye Pressure Following Laser (SLT)Treatment in the Management of Glaucoma.
- Conditions
- Open Angle Glaucoma
- First Posted Date
- 2007-02-27
- Last Posted Date
- 2007-03-01
- Lead Sponsor
- Advanced Glaucoma Specialists
- Target Recruit Count
- 30
- Registration Number
- NCT00440336
- Locations
- 🇺🇸
Advanced Glaucoma Specialist, Reading, Massachusetts, United States
12-Month Stability of Diurnal IOP Control on Cosopt
- First Posted Date
- 2006-09-25
- Last Posted Date
- 2015-02-10
- Lead Sponsor
- West Virginia University
- Target Recruit Count
- 10
- Registration Number
- NCT00379834
A Study of Glaucoma Therapy to Treat Open-Angle Glaucoma or Ocular Hypertension
- Conditions
- Ocular HypertensionGlaucoma
- Interventions
- First Posted Date
- 2006-06-02
- Last Posted Date
- 2016-11-18
- Lead Sponsor
- Alcon Research
- Target Recruit Count
- 319
- Registration Number
- NCT00333125
A Study of a Glaucoma Therapy to Treat Open-Angle Glaucoma or Ocular Hypertension
- Conditions
- Open-angle GlaucomaOcular Hypertension
- Interventions
- First Posted Date
- 2006-04-13
- Last Posted Date
- 2016-11-18
- Lead Sponsor
- Alcon Research
- Target Recruit Count
- 437
- Registration Number
- NCT00314171
Effects of Common Topical Glaucoma Therapy on Optic Nerve Head Blood Flow Autoregulation During Increased Arterial Blood Pressure and Artificially Elevated Intraocular Pressure in Healthy Humans
- Conditions
- Glaucoma
- Interventions
- Device: Laser Doppler flowmetryDevice: Goldmann applanation tonometerProcedure: Suction cup method
- First Posted Date
- 2006-01-12
- Last Posted Date
- 2014-11-21
- Lead Sponsor
- Medical University of Vienna
- Registration Number
- NCT00275756
- Locations
- 🇦🇹
Department of Clinical Pharmacology, Vienna, Austria
Drug Development Updates
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