Tranexamic acid

Generic Name
Tranexamic acid
Brand Names
Cyklokapron, Lysteda
Drug Type
Small Molecule
Chemical Formula
C8H15NO2
CAS Number
1197-18-8
Unique Ingredient Identifier
6T84R30KC1
Background

Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.

It was first patented in 1957 and received its initial US approval in 1986.

Indication

Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleed...

Associated Conditions
Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
Associated Therapies
-

Hemostasis in Open Acetabulum and Pelvic Ring Surgery Using Tranexamic Acid

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2014-01-31
Last Posted Date
2018-02-27
Lead Sponsor
University of Missouri-Columbia
Target Recruit Count
88
Registration Number
NCT02051686
Locations
🇺🇸

University of Missouri, Columbia, Missouri, United States

Tranexamic Acid in Reverse Total Shoulder Arthroplasty

First Posted Date
2014-01-23
Last Posted Date
2017-06-19
Lead Sponsor
William Beaumont Hospitals
Target Recruit Count
116
Registration Number
NCT02043132
Locations
🇺🇸

William Beaumont Hospital, Royal Oak, Michigan, United States

Tranexamic Acid and Thromboelastography During Cesarean Delivery

First Posted Date
2014-01-01
Last Posted Date
2020-10-27
Lead Sponsor
Brigham and Women's Hospital
Target Recruit Count
60
Registration Number
NCT02026297
Locations
🇺🇸

Brigham and Women's Hospital, Boston, Massachusetts, United States

Prospective Trial of Tranexamic Acid in Cardiac Surgery

Phase 4
Completed
Conditions
Interventions
First Posted Date
2013-11-28
Last Posted Date
2016-02-26
Lead Sponsor
Hongwen Ji
Target Recruit Count
955
Registration Number
NCT01998438
Locations
🇨🇳

Cardiovascular Institute and Fuwai Hospital, CAMS&PUMC, Beijing, Beijing, China

TXA Study in Major Oncologic Surgery

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2013-11-08
Last Posted Date
2023-08-07
Lead Sponsor
Spectrum Health Hospitals
Target Recruit Count
76
Registration Number
NCT01980355
Locations
🇺🇸

Spectrum Health Hospitals, Grand Rapids, Michigan, United States

The Effect of Topical Administration of Common Drugs on Postoperative Bleeding and Pain

First Posted Date
2013-10-17
Last Posted Date
2019-05-17
Lead Sponsor
St. Olavs Hospital
Target Recruit Count
30
Registration Number
NCT01964781
Locations
🇳🇴

St Olavs University Hospital, Trondheim, Norway

The Effect of Tranexamic Acid on Transfusion Rates in Intertrochanteric Hip Fractures

Phase 4
Withdrawn
Conditions
Interventions
First Posted Date
2013-09-12
Last Posted Date
2017-03-28
Lead Sponsor
Hospital for Special Surgery, New York
Registration Number
NCT01940536
Locations
🇺🇸

New York Presbyterian Hospital, New York, New York, United States

Testing of the Drug Tranexamic Acids as Prophylaxis of Bleeding in Benign Surgical Removal of the Uterus

First Posted Date
2013-09-12
Last Posted Date
2015-10-22
Lead Sponsor
Hillerod Hospital, Denmark
Target Recruit Count
332
Registration Number
NCT01940419
Locations
🇩🇰

Department of gynecology and obstetrics, Nordsjællands Hospital, Hillerød, Denmark

The Role of Tranexamic Acid in Reducing Blood Transfusion Requirements After Cardiopulmonary Bypass in Neonates

First Posted Date
2013-08-02
Last Posted Date
2017-02-01
Lead Sponsor
Aymen N Naguib
Registration Number
NCT01914211
Locations
🇺🇸

Nationwide Children's Hospital, Columbus, Ohio, United States

Mechanism and Early Intervention Research on ALI During Emergence Surgery of Acute Stanford A Aortic Dissection

First Posted Date
2013-07-10
Last Posted Date
2014-01-24
Lead Sponsor
Beijing Anzhen Hospital
Target Recruit Count
220
Registration Number
NCT01894334
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