Tranexamic acid
- Generic Name
- Tranexamic acid
- Brand Names
- Cyklokapron, Lysteda
- Drug Type
- Small Molecule
- Chemical Formula
- C8H15NO2
- CAS Number
- 1197-18-8
- Unique Ingredient Identifier
- 6T84R30KC1
- Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.
It was first patented in 1957 and received its initial US approval in 1986.
- Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleed...
- Associated Conditions
- Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
- Associated Therapies
- -
Tranexamic Acid in Off-pump Coronary Surgery
- Conditions
- Interventions
- First Posted Date
- 2010-02-08
- Last Posted Date
- 2011-02-03
- Target Recruit Count
- 231
- Registration Number
- NCT01064167
- Locations
- 🇨🇳
Cardiovascular Institute and Fuwai Hospital, Beijing, China
Tranexamic Acid in Clopidogrel Exposure to Decrease Hemorrhage and Transfusion
- Conditions
- Interventions
- First Posted Date
- 2010-02-02
- Last Posted Date
- 2011-11-22
- Target Recruit Count
- 552
- Registration Number
- NCT01060163
- Locations
- 🇨🇳
Capital Medical University affiliated Beijing Anzhen Hospital, Beijing, Beijing, China
🇨🇳General Hospital of Chinese People's Liberation Army, Beijing, Beijing, China
🇨🇳Cardiovascular Institute and Fuwai Hospital, CMAS&PUMC, Beijing, Beijing, China
Three Dose Regimen of Tranexamic Acid in Cardiac Surgery
- First Posted Date
- 2010-02-02
- Last Posted Date
- 2019-02-05
- Target Recruit Count
- 600
- Registration Number
- NCT01060176
- Locations
- 🇨🇳
Cardiovascular Institute and Fuwai Hospital, CAMS&PUMC, Beijing, Beijing, China
Hemostatic Effects of Ulinastatin and Tranexamic Acid in Cardiac Surgery
- Conditions
- Interventions
- First Posted Date
- 2010-02-02
- Last Posted Date
- 2019-02-05
- Target Recruit Count
- 426
- Registration Number
- NCT01060189
- Locations
- 🇨🇳
Cardiovascular Institute and Fuwai Hospital, CAMS&PUMC, Beijing, Beijing, China
Effect of Tranexamic Acid on Reducing Postoperative Blood Loss in Cervical Laminoplasty
- First Posted Date
- 2009-12-08
- Last Posted Date
- 2009-12-08
- Lead Sponsor
- Yodakubo Hospital
- Target Recruit Count
- 40
- Registration Number
- NCT01027546
Effect of Tranexamic Acid in Upper Gastrointestinal Bleeding
- Conditions
- Interventions
- First Posted Date
- 2009-10-30
- Last Posted Date
- 2012-04-09
- Lead Sponsor
- University of Oklahoma
- Registration Number
- NCT01005147
Tranexamic Acid in Pediatric Cardiac Surgery
- Conditions
- Interventions
- First Posted Date
- 2009-10-14
- Last Posted Date
- 2009-10-14
- Lead Sponsor
- Okayama University
- Target Recruit Count
- 160
- Registration Number
- NCT00994994
Topical Tranexamic Acid for Total Knee Arthroplasty
- Conditions
- Interventions
- First Posted Date
- 2009-09-29
- Last Posted Date
- 2011-04-11
- Lead Sponsor
- University Health Network, Toronto
- Target Recruit Count
- 125
- Registration Number
- NCT00985920
- Locations
- 🇨🇦
Toronto Western Hospital, Toronto, Ontario, Canada
Tranexamic Acid (TXA) Versus Epsilon Aminocaproic Acid (EACA) Versus Placebo for Spine Surgery
- Conditions
- Interventions
- First Posted Date
- 2009-08-13
- Last Posted Date
- 2018-01-17
- Lead Sponsor
- NYU Langone Health
- Target Recruit Count
- 177
- Registration Number
- NCT00958581
- Locations
- 🇺🇸
New York University School of Medicine - Department of Orthopaedic Surgery - Spine, New York, New York, United States
The Assessment of Tranexamic Acid in Women With Menorrhagia Who Have Bleeding Disorders
- First Posted Date
- 2009-05-20
- Last Posted Date
- 2018-07-18
- Lead Sponsor
- K. Sue Robinson
- Target Recruit Count
- 249
- Registration Number
- NCT00904709
Drug Development Updates
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