Tranexamic acid

Generic Name
Tranexamic acid
Brand Names
Cyklokapron, Lysteda
Drug Type
Small Molecule
Chemical Formula
C8H15NO2
CAS Number
1197-18-8
Unique Ingredient Identifier
6T84R30KC1
Background

Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.

It was first patented in 1957 and received its initial US approval in 1986.

Indication

Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleed...

Associated Conditions
Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
Associated Therapies
-
Clinical Trials
Related News

Clinical Randomisation of an Antifibrinolytic in Significant Head Injury

Phase 3
Completed
Conditions
Traumatic Brain Injury
Interventions
Drug: Tranexamic Acid
First Posted Date
2011-07-26
Last Posted Date
2020-02-17
Lead Sponsor
London School of Hygiene and Tropical Medicine
Target Recruit Count
12737
Registration Number
NCT01402882
Locations
🇬🇪

High Technology Medical Center, University Clinic, Tbilisi, Georgia

Topical Tranexamic Acid and Acute Blood Loss in Total Knee Arthroplasty

First Posted Date
2011-06-10
Last Posted Date
2023-04-25
Lead Sponsor
Henry Ford Health System
Target Recruit Count
101
Registration Number
NCT01370460
Locations
🇺🇸

Henry Ford Hospital, Detroit, Michigan, United States

Can we Use Intravenous Injection of Tranexamic Acid in Routine Practice With Active Management of the Third Stage of Labor?

Phase 3
Completed
Conditions
Obstetrical Hemorrhage
Interventions
Drug: transamin
First Posted Date
2011-04-19
Last Posted Date
2011-11-17
Lead Sponsor
Erzincan Military Hospital
Target Recruit Count
450
Registration Number
NCT01338454
Locations
🇹🇷

Bakıryok Women and Children Hospital, İstanbul, Bakırkoy, Turkey

Tranexamic Acid in Hip Fracture Patients

Not Applicable
Conditions
Closed Fracture of Hip
Interventions
Drug: Tranexamic acid
First Posted Date
2011-03-30
Last Posted Date
2012-06-07
Lead Sponsor
Michal Roll PhD,MBA
Target Recruit Count
60
Registration Number
NCT01326403
Locations
🇮🇱

Sourasky Medical Center, Tel Aviv, Israel

Fibrin Glue or Tranexamic Acid for Total Knee Arthroplasty

First Posted Date
2011-03-01
Last Posted Date
2013-08-28
Lead Sponsor
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Target Recruit Count
172
Registration Number
NCT01306370
Locations
🇪🇸

Hospital de la Santa Creu i Sant Pau, Barcelona, Catalunya, Spain

Management of Initial Bleeding/Spotting Associated With the Levonorgestrel-releasing Intrauterine System (MIRENA)

First Posted Date
2011-02-14
Last Posted Date
2014-11-04
Lead Sponsor
Bayer
Target Recruit Count
187
Registration Number
NCT01295294

A Study of Tranexamic Acid (XP12B) in Women With Heavy Menstrual Bleeding

Phase 3
Completed
Conditions
Menorrhagia
Interventions
Drug: Tranexamic acid
First Posted Date
2011-01-21
Last Posted Date
2011-07-26
Lead Sponsor
Ferring Pharmaceuticals
Target Recruit Count
288
Registration Number
NCT01280981
Locations
🇺🇸

Clinical Trials of Virginia, INC, Richmond, Virginia, United States

🇺🇸

Valley Women's Clinic, Renton, Washington, United States

🇺🇸

North Spokane Women's Center, Spokane, Washington, United States

and more 86 locations

Topical Application of Tranexamic Acid Reduces Postoperative Blood Loss in Total Hip Arthroplasty

First Posted Date
2010-12-15
Last Posted Date
2011-12-01
Lead Sponsor
The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine
Target Recruit Count
100
Registration Number
NCT01260818
Locations
🇨🇳

the First Affiliated Hospital of Guangzhou TCM University, Guangzhou, Guangdong, China

Impact of Tranexamic Acid on Red Blood Cell Transfusion in Spinal Surgery

First Posted Date
2010-12-10
Last Posted Date
2014-05-01
Lead Sponsor
Centre hospitalier de l'Université de Montréal (CHUM)
Target Recruit Count
99
Registration Number
NCT01258010
Locations
🇨🇦

Centre Hospitalier de l'Université de Montréal-Hôpital Notre-Dame, Montreal, Quebec, Canada

Comparison of Tranexamic to Epsilon Aminocaproic Acid: a Prospective Analysis of Blood Conservation in Cardiac Surgery

Not Applicable
Completed
Conditions
Cardiopulmonary Bypass
Interventions
Drug: Tranexamic Acid
Drug: Aminocaproic Acid
First Posted Date
2010-11-25
Last Posted Date
2020-10-19
Lead Sponsor
Loma Linda University
Target Recruit Count
100
Registration Number
NCT01248104
Locations
🇺🇸

Loma Linda University Medical Center, Loma Linda, California, United States

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