Nitroglycerin
- Generic Name
- Nitroglycerin
- Brand Names
- Gonitro, Minitran, Mylan-nitro, Nitro-bid, Nitro-dur, Nitroject, Nitrolingual, Nitromist, Nitrostat, Rectiv, Trinipatch
- Drug Type
- Small Molecule
- Chemical Formula
- C3H5N3O9
- CAS Number
- 55-63-0
- Unique Ingredient Identifier
- G59M7S0WS3
- Background
Nitroglycerin, also known as glyceryl trinitrate, is an organic nitrate and a vasodilating agent that was first discovered in 1847. Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure experienced relief from chest pain. Its use as a treatment for angina dates back to 1879 and is still used to treat and prevent angina. Nitroglycerin causes vasodilation in both arteries and veins.
Nitroglycerin is used in a variety of different conditions, including angina pectoris due to coronary artery disease, peri-operative hypertension, congestive heart failure, and chronic anal fissure. It is also used to induce intraoperative hypotension.
- Indication
Sublingual nitroglycerin is indicated for the acute relief of an attack or acute prophylaxis of angina pectoris due to coronary artery disease. Transdermal nitroglycerin is indicated for the prevention of angina pectoris due to coronary artery disease.
Intravenous nitroglycerin is indicated for the treatment of peri-operative hypertension; for control of congestive heart failure in the setting of acute myocardial infarction; for treatment of angina pectoris in patients who have not responded to sublingual nitroglycerin and beta (β)-blockers; and for induction of intraoperative hypotension.
Topical nitroglycerin ointment is used to treat moderate to severe pain associated with chronic anal fissure.
- Associated Conditions
- Angina Attacks, Angina Pectoris, Congestive Heart Failure (CHF), Perioperative Hypertension, Moderate to severe pain
Study of the Glymphatic System in Migraine
- Conditions
- Migraine
- Interventions
- First Posted Date
- 2023-06-18
- Last Posted Date
- 2023-06-22
- Lead Sponsor
- IRCCS San Raffaele
- Target Recruit Count
- 50
- Registration Number
- NCT05907655
- Locations
- 🇮🇹
IRCCS San Raffaele Hospital, Milan, Italy
The Use of Platelet-rich Plasma in the Treatment of Chronic Anal Fissure
- Conditions
- Fissure in Ano
- Interventions
- Procedure: Platelet rich plasma injection
- First Posted Date
- 2023-05-01
- Last Posted Date
- 2023-05-03
- Lead Sponsor
- Al-Kindy College of Medicine
- Target Recruit Count
- 460
- Registration Number
- NCT05837403
- Locations
- 🇮🇶
Al-Kindy Teaching Hospital, Baghdad, Iraq
A Cohort Prospective Study of Predictors Influencing the Quality of Visualization of the Operating Field During Orthognathic Surgery
- Conditions
- HemorrhageMaxillofacial InjuriesOrthodonticsMalocclusion
- Interventions
- Device: monitoring of cerebral oxygen saturation
- First Posted Date
- 2023-04-18
- Last Posted Date
- 2023-05-31
- Lead Sponsor
- State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia
- Target Recruit Count
- 100
- Registration Number
- NCT05814991
- Locations
- 🇷🇺
Pirogov National Medical and Surgical Center, Moscow, Russian Federation
The Effect Of Nebulizied Nitroglycerin As An Adjuvant Therapy For Persistent Pulmonary Hypertension Of Newborns
- Conditions
- Respiratory DiseasePersistent Pulmonary Hypertension of the NewbornEchocardiography
- Interventions
- Drug: conventional therapy for PPHN
- First Posted Date
- 2023-02-23
- Last Posted Date
- 2025-02-05
- Lead Sponsor
- Alexandria University
- Target Recruit Count
- 80
- Registration Number
- NCT05741229
- Locations
- 🇪🇬
Alexandria University, Alexandria, Egypt
Habituation of the Nociceptive Blink Reflex in Experimentally Induced Migraine Attack
- Conditions
- Migraine DisordersPainMigraine
- Interventions
- Drug: Saline
- First Posted Date
- 2023-02-08
- Last Posted Date
- 2023-02-08
- Target Recruit Count
- 22
- Registration Number
- NCT05718310
- Locations
- 🇮🇹
IRCCS Mondino Foundation, Pavia, Italy
🇮🇹Headache Science & Neurorehabilitation Center, Pavia, Italy
Effect of Glyceroltrinitrate on Human Energy Expenditure and Brown Adipose Tissue Thermogenesis
- Conditions
- Brown Adipose Tissue
- Interventions
- First Posted Date
- 2023-02-02
- Last Posted Date
- 2025-05-16
- Lead Sponsor
- University Hospital, Basel, Switzerland
- Target Recruit Count
- 25
- Registration Number
- NCT05711199
- Locations
- 🇨🇭
University Hospital Basel, Department of Endocrinology, Basel, BS, Switzerland
Application of Intraoperative Transesophageal Echocardiography Imaging of Vein and CLCVP in Early Prediction and Intervention CSA-AKI
- Conditions
- Acute Kidney Injury
- Interventions
- Combination Product: Controlled low central venous pressure (CLCVP) technology
- First Posted Date
- 2023-01-12
- Last Posted Date
- 2023-01-12
- Target Recruit Count
- 137
- Registration Number
- NCT05682716
- Locations
- 🇨🇳
Nanjing First Hospital, Nanjing, Jiangsu, China
Efficacy and Safety of Propionibacterium Extract Gel Versus 0.4% Glyceryl Trinitrate Ointment in the Treatment of Chronic Anal Fissure: a Randomised Controlled Trial
- Conditions
- Anal Fissure ChronicAnal Fissure
- Interventions
- Drug: Propionibacterium Acnes
- First Posted Date
- 2022-11-15
- Last Posted Date
- 2022-11-15
- Lead Sponsor
- Treviso Regional Hospital
- Target Recruit Count
- 120
- Registration Number
- NCT05616455
- Locations
- 🇮🇹
Regional Hospital Treviso, Treviso, Italy
Subcutaneous Nitroglycerin to Prevent Radial Artery Occlusion in Children
- Conditions
- IschemiaArterial Line
- Interventions
- Drug: Normal saline
- First Posted Date
- 2022-07-05
- Last Posted Date
- 2025-04-29
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 200
- Registration Number
- NCT05443061
- Locations
- 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of
Comparison Between Pregabalin and Magnesium Sulfate in Hypotensive Anaesthesia
- Conditions
- Functional Endoscopic Sinus Surgery
- Interventions
- First Posted Date
- 2022-07-05
- Last Posted Date
- 2022-07-05
- Lead Sponsor
- Minia University
- Target Recruit Count
- 60
- Registration Number
- NCT05442931
- Locations
- 🇪🇬
Faculty of medicine, Minya, Egypt
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.