Nitroglycerin

Generic Name: Nitroglycerin

Brand Names: Gonitro, Minitran, Mylan-nitro, Nitro-bid, Nitro-dur, Nitroject, Nitrolingual, Nitromist, Nitrostat, Rectiv, Trinipatch

Drug Type: Small Molecule

Chemical Formula: C_₃H_₅N_₃O_₉

CAS Number: 55-63-0

Unique Ingredient Identifier: G59M7S0WS3

Background: Nitroglycerin, also known as glyceryl trinitrate, is an organic nitrate and a vasodilating agent that was first discovered in 1847. Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure experienced relief from chest pain. Its u...

Indication: Sublingual nitroglycerin is indicated for the acute relief of an attack or acute prophylaxis of angina pectoris due to coronary artery disease. Transdermal nitroglycerin is indicated for the prevention of angina pectoris due to coronary artery disease.
...

Associated Conditions: Angina Attacks, Angina Pectoris, Congestive Heart Failure (CHF), Perioperative Hypertension, Moderate to severe pain

Associated Therapies: -

Clinical Trials

PericOronary INflammaTion in Non-Obstructive Coronary Artery Disease

Recruiting

Conditions: Non-Obstructive Coronary Atherosclerosis

Interventions: Procedure: Coronary computed tomography angiography (CCTA)
Drug: Isovue
Drug: Nitroglycerin
Drug: Metoprolol

First Posted Date: 2021-09-02

Last Posted Date: 2024-05-02

Lead Sponsor: NYU Langone Health

Target Recruit Count: 100

Registration Number: NCT05031520

Locations: 🇺🇸
NYU Langone Health, New York, New York, United States

Nitroglycerine Versus Dexmedetomidine Infusion in Intraoperative Management of Uncontrolled Hypertension

Completed

Conditions: Hypertension

Interventions: Drug: Dexmedetomidine
Drug: Nitroglycerin

First Posted Date: 2021-07-07

Last Posted Date: 2023-01-10

Lead Sponsor: National Cancer Institute, Egypt

Target Recruit Count: 77

Registration Number: NCT04953156

Locations: 🇪🇬
National Cancer Institute, Cairo, Egypt

Changes in Cerebral Oxygenation and Cognitive Functions

Completed

Conditions: Hypotension; Controlled
Cognitive Dysfunction

Interventions: Drug: Esmolol
Drug: Nitroglycerin

First Posted Date: 2021-07-02

Last Posted Date: 2021-07-02

Lead Sponsor: Zonguldak Bulent Ecevit University

Target Recruit Count: 40

Registration Number: NCT04948957

Locations: 🇹🇷
Zonguldak Bülent Ecevit University Medicine Faculty, Zonguldak, Kozlu, Turkey

Endothelium Dependent and Non-dependent Vasodilatation in Human Gingiva

Not Applicable

Completed

Conditions: Vasodilatation
Oral Soft Tissue Conditions

Interventions: Drug: Acetylcholine
Drug: Nitroglycerin

First Posted Date: 2021-06-09

Last Posted Date: 2021-06-14

Lead Sponsor: Semmelweis University

Target Recruit Count: 24

Registration Number: NCT04918563

Locations: 🇭🇺
Semmelweis University, Department of Conservative Dentistry, Budapest, Hungary

Efficacy of Inhaled Nitroglycerin in Moderate to Critically Ill COVID-19 Patients

Not Applicable

Completed

Conditions: Corona Virus Infection

Interventions: Drug: Nitroglycerin

First Posted Date: 2020-12-29

Last Posted Date: 2022-05-18

Lead Sponsor: University of Lahore

Target Recruit Count: 278

Registration Number: NCT04686760

Locations: 🇵🇰
Bahria Town International Hospital, Lahore, Punjab, Pakistan

Efficacy and Safety of Wen Xin Granules for the Treatment of Unstable Angina Pectoris

Phase 4

Conditions: Coronary Heart Disease
Unstable Angina
Chinese Herbal Medicine

Interventions: Drug: Clopidogrel Hydrogen Sulfate 75 MG Oral Tablet
Drug: Wen Xin granule
Drug: Atorvastatin Calcium
Drug: Isosorbide Mononitrate Tab 20 MG
Drug: Metoprolol Tartrate Tab 25 MG
Drug: Aspirin Enteric-coated Tablets
Drug: WXG placebo
Drug: Trimetazidine Dihydrochloride Tablets
Drug: glyceryl trinitrate

First Posted Date: 2020-12-10

Last Posted Date: 2021-01-25

Lead Sponsor: Guang'anmen Hospital of China Academy of Chinese Medical Sciences

Target Recruit Count: 502

Registration Number: NCT04661709

PGI2 Versus Nitroglycerine for Management of Pulmonary Hypertension After Valve Surgeries

Phase 1

Conditions: Pulmonary Hypertension

Interventions: Drug: PGI2
Drug: Nitroglycerin

First Posted Date: 2020-10-20

Last Posted Date: 2020-10-20

Lead Sponsor: Ain Shams University

Target Recruit Count: 120

Registration Number: NCT04594629

Locations: 🇪🇬
Ain Shams university, Cairo, Egypt

Nitroglycerin for Intra-arterial Chemotherapy in Pediatric Retinoblastoma.

Not Applicable

Recruiting

Conditions: Retinoblastoma

Interventions: Drug: Nitroglycerin
Drug: Normal saline

First Posted Date: 2020-09-25

Last Posted Date: 2023-11-22

Lead Sponsor: Seoul National University Hospital

Target Recruit Count: 36

Registration Number: NCT04564521

Locations: 🇰🇷
Jin-Tae Kim, Seoul, Korea, Republic of

Comparison Between Two Drugs (Propofol and Nitroglycerin as a Hypotensive Agents During Endoscopic Sinus Surgery

Phase 1

Terminated

Conditions: Hypotensive Anesthesia

Interventions: Drug: Propofol
Drug: Nitroglycerin

First Posted Date: 2020-01-07

Last Posted Date: 2020-02-17

Lead Sponsor: Ain Shams University

Target Recruit Count: 40

Registration Number: NCT04220281

Locations: 🇪🇬
Ain Shams University Hospital, Cairo, EL Abassia, Egypt

The Effect of Periradial Injection of Papaverine Versus Nitroglycerine on Radial Artery Diameter

Early Phase 1

Completed

Conditions: Radial Artery Injury Prevetion

Interventions: Drug: xlyocaine
Drug: nitroglycerine
Drug: papaverine

First Posted Date: 2019-07-24

Last Posted Date: 2020-09-16

Lead Sponsor: Kasr El Aini Hospital

Target Recruit Count: 90

Registration Number: NCT04030663

Locations: 🇪🇬
Faculty of Medicine, Cairo, Benisuef, Egypt

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