Nitroglycerin
- Generic Name
- Nitroglycerin
- Brand Names
- Gonitro, Minitran, Mylan-nitro, Nitro-bid, Nitro-dur, Nitroject, Nitrolingual, Nitromist, Nitrostat, Rectiv, Trinipatch
- Drug Type
- Small Molecule
- Chemical Formula
- C3H5N3O9
- CAS Number
- 55-63-0
- Unique Ingredient Identifier
- G59M7S0WS3
- Background
Nitroglycerin, also known as glyceryl trinitrate, is an organic nitrate and a vasodilating agent that was first discovered in 1847. Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure experienced relief from chest pain. Its use as a treatment for angina dates back to 1879 and is still used to treat and prevent angina. Nitroglycerin causes vasodilation in both arteries and veins.
Nitroglycerin is used in a variety of different conditions, including angina pectoris due to coronary artery disease, peri-operative hypertension, congestive heart failure, and chronic anal fissure. It is also used to induce intraoperative hypotension.
- Indication
Sublingual nitroglycerin is indicated for the acute relief of an attack or acute prophylaxis of angina pectoris due to coronary artery disease. Transdermal nitroglycerin is indicated for the prevention of angina pectoris due to coronary artery disease.
Intravenous nitroglycerin is indicated for the treatment of peri-operative hypertension; for control of congestive heart failure in the setting of acute myocardial infarction; for treatment of angina pectoris in patients who have not responded to sublingual nitroglycerin and beta (β)-blockers; and for induction of intraoperative hypotension.
Topical nitroglycerin ointment is used to treat moderate to severe pain associated with chronic anal fissure.
- Associated Conditions
- Angina Attacks, Angina Pectoris, Congestive Heart Failure (CHF), Perioperative Hypertension, Moderate to severe pain
Effect of Local Anesthesia Versus Induced Hypotensive Anesthesia on Quality of External Dacryocystorhinostomy Operation
- Conditions
- Patient With Nasolacrimal Duct ObstructionExternal Dacryocystorhinostomy Operation
- Interventions
- Procedure: Mechanical ventilationOther: Head-up tilt
- First Posted Date
- 2022-02-15
- Last Posted Date
- 2022-02-15
- Lead Sponsor
- Mansoura University
- Target Recruit Count
- 64
- Registration Number
- NCT05241054
- Locations
- 🇪🇬
Mansoura University, Mansoura, DK, Egypt
Safety and Tolerability of Nitro for Radial Artery Dilation
- First Posted Date
- 2022-02-14
- Last Posted Date
- 2022-04-06
- Lead Sponsor
- Thomas Jefferson University
- Target Recruit Count
- 20
- Registration Number
- NCT05239013
Physiologic Effect of Topical Nitroglycerin on Microcirculation Capacity in Patients With Circulatory Shock.
- Conditions
- Circulatory ShockCardiovascular Shock
- Interventions
- First Posted Date
- 2021-11-01
- Last Posted Date
- 2024-04-01
- Lead Sponsor
- University of Pennsylvania
- Target Recruit Count
- 44
- Registration Number
- NCT05102734
- Locations
- 🇺🇸
Hospital of the University of the Pennsylvania, Philadelphia, Pennsylvania, United States
PericOronary INflammaTion in Non-Obstructive Coronary Artery Disease
- Conditions
- Non-Obstructive Coronary Atherosclerosis
- Interventions
- Procedure: Coronary computed tomography angiography (CCTA)
- First Posted Date
- 2021-09-02
- Last Posted Date
- 2025-04-29
- Lead Sponsor
- NYU Langone Health
- Target Recruit Count
- 100
- Registration Number
- NCT05031520
- Locations
- 🇺🇸
NYU Langone Health, New York, New York, United States
Nitroglycerine Versus Dexmedetomidine Infusion in Intraoperative Management of Uncontrolled Hypertension
- First Posted Date
- 2021-07-07
- Last Posted Date
- 2023-01-10
- Lead Sponsor
- National Cancer Institute, Egypt
- Target Recruit Count
- 77
- Registration Number
- NCT04953156
- Locations
- 🇪🇬
National Cancer Institute, Cairo, Egypt
Changes in Cerebral Oxygenation and Cognitive Functions
- Conditions
- Hypotension; ControlledCognitive Dysfunction
- Interventions
- First Posted Date
- 2021-07-02
- Last Posted Date
- 2021-07-02
- Lead Sponsor
- Zonguldak Bulent Ecevit University
- Target Recruit Count
- 40
- Registration Number
- NCT04948957
- Locations
- 🇹🇷
Zonguldak Bülent Ecevit University Medicine Faculty, Zonguldak, Kozlu, Turkey
Endothelium Dependent and Non-dependent Vasodilatation in Human Gingiva
- Conditions
- VasodilatationOral Soft Tissue Conditions
- Interventions
- First Posted Date
- 2021-06-09
- Last Posted Date
- 2021-06-14
- Lead Sponsor
- Semmelweis University
- Target Recruit Count
- 24
- Registration Number
- NCT04918563
- Locations
- 🇭🇺
Semmelweis University, Department of Conservative Dentistry, Budapest, Hungary
Efficacy of Inhaled Nitroglycerin in Moderate to Critically Ill COVID-19 Patients
- First Posted Date
- 2020-12-29
- Last Posted Date
- 2022-05-18
- Lead Sponsor
- University of Lahore
- Target Recruit Count
- 278
- Registration Number
- NCT04686760
- Locations
- 🇵🇰
Bahria Town International Hospital, Lahore, Punjab, Pakistan
Ointment Therapy and Prevention of Cannulation-Induced Superficial Phlebitis
- First Posted Date
- 2020-12-28
- Last Posted Date
- 2020-12-28
- Lead Sponsor
- Komar University of Science and Technology
- Target Recruit Count
- 110
- Registration Number
- NCT04685031
Efficacy and Safety of Wen Xin Granules for the Treatment of Unstable Angina Pectoris
- Conditions
- Coronary Heart DiseaseUnstable AnginaChinese Herbal Medicine
- Interventions
- First Posted Date
- 2020-12-10
- Last Posted Date
- 2021-01-25
- Target Recruit Count
- 502
- Registration Number
- NCT04661709
Drug Development Updates
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