Midazolam

Generic Name: Midazolam

Brand Names: Buccolam, Busulfex, Nayzilam, Seizalam

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₁₃ClFN_₃

CAS Number: 59467-70-8

Unique Ingredient Identifier: R60L0SM5BC

Background: Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called benzodiazepines. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Midazolam is available by oral, rectal, intranasal...

Indication: Midazolam has different indications depending on its formulation by the FDA.

Nasal
...

Associated Conditions: Epileptic seizure, Status Epilepticus

Associated Therapies: Anaesthesia, Anxiolytic therapy therapy, Sedation for mechanically-ventilated patients, Preoperative amnesia therapy, Preoperative sedation therapy

Clinical Trials

Safety, Efficacy and Pharmacokinetic Study of Dexmedetomidine in Pediatrics Ages ≥28 Weeks to ≤44 Weeks Gestational Age

Phase 2

Completed

Conditions: Sedation

Interventions: Drug: Midazolam
Drug: Fentanyl/Morphine
Drug: Dexmedetomidine

First Posted Date: 2010-07-09

Last Posted Date: 2015-08-13

Lead Sponsor: Hospira, now a wholly owned subsidiary of Pfizer

Target Recruit Count: 36

Registration Number: NCT01159262

Locations: 🇺🇸
Childrens Hospital Los Angeles, Los Angeles, California, United States
🇺🇸
Georgia Health Sciences University, Augusta, Georgia, United States
🇺🇸
Loyola University Medical Center, Maywood, Illinois, United States

and more 12 locations

Propofol Versus Midazolam for Upper Endoscopy in Cirrhotic Patients

Not Applicable

Completed

Conditions: Cirrhosis

Interventions: Drug: propofol
Drug: Midazolam

First Posted Date: 2010-06-10

Last Posted Date: 2010-06-10

Lead Sponsor: Ziv Hospital

Target Recruit Count: 60

Registration Number: NCT01141036

Locations: 🇮🇱
Ziv medical center liver unit, Safed, Israel, Israel

Dexmedetomidine Versus Midazolam for Intensive Care Sedation of Children

Phase 3

Conditions: Sedation

Interventions: Drug: Midazolam
Drug: dexmedetomidine

First Posted Date: 2010-03-24

Last Posted Date: 2011-07-21

Lead Sponsor: Ullevaal University Hospital

Target Recruit Count: 40

Registration Number: NCT01091818

Locations: 🇳🇴
Dept of Anesthesiology, Oslo University Hospital, Ullevaal, Oslo, Norway

Effect of Ridaforolimus on the Pharmacokinetics of Midazolam (Study MK-8669-044)

Phase 1

Completed

Conditions: Relapsed or Refractory Advanced Cancer

Interventions: Drug: Midazolam
Drug: Ridaforolimus

First Posted Date: 2010-02-19

Last Posted Date: 2015-04-10

Lead Sponsor: Merck Sharp & Dohme LLC

Target Recruit Count: 16

Registration Number: NCT01071304

A Study in Healthy Volunteers to Assess Effect of AZD6765 on Midazolam Blood Levels

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: AZD6765
Drug: midazolam

First Posted Date: 2010-02-17

Last Posted Date: 2014-10-13

Lead Sponsor: AstraZeneca

Target Recruit Count: 46

Registration Number: NCT01069822

Locations: 🇺🇸
Research Site, Overland Park, Kansas, United States

Premedication and Haemodynamics After Spinal Anesthesia

Not Applicable

Completed

Conditions: Hemodynamics After Spinal Anesthesia

Interventions: Drug: Midazolam
Drug: Morphine hydrochloride; Midazolam

First Posted Date: 2010-02-10

Last Posted Date: 2011-07-26

Lead Sponsor: Medical University of Gdansk

Target Recruit Count: 60

Registration Number: NCT01066247

Locations: 🇵🇱
Medical University of Gdansk, Gdansk, Poland

Dexmedetomidine Versus Propofol in the Medical Intensive Care Unit (MICU)

Phase 4

Terminated

Conditions: Critical Illness
Mechanical Ventilation

Interventions: Drug: Dexmedetomidine
Drug: Propofol
Drug: Fentanyl
Drug: Midazolam
Behavioral: Physical and Occupational Therapy

First Posted Date: 2010-02-01

Last Posted Date: 2018-07-03

Lead Sponsor: University of Chicago

Target Recruit Count: 41

Registration Number: NCT01059929

Locations: 🇺🇸
The University of Chicago Medical Center, Chicago, Illinois, United States

Prophylaxis Against Metoclopramide-Induced Akathisia

Not Applicable

Completed

Conditions: Akathisia

Interventions: Drug: midazolam

First Posted Date: 2010-01-18

Last Posted Date: 2010-01-18

Lead Sponsor: Pamukkale University

Target Recruit Count: 225

Registration Number: NCT01051271

Randomized Study With Midazolam for Sedation in Flexible Bronchoscopy

Not Applicable

Completed

Conditions: Sedation
Tolerance
Anxiety
Satisfaction

Interventions: Other: Physiological serum
Drug: Midazolam

First Posted Date: 2009-12-24

Last Posted Date: 2009-12-24

Lead Sponsor: Hospital Universitario La Fe

Target Recruit Count: 238

Registration Number: NCT01038882

Locations: 🇪🇸
Hospital Universaitario La Fe, Valencia, Spain

Clinical Pharmacology Study of Brentuximab Vedotin (SGN-35)

Phase 1

Completed

Conditions: Lymphoma, Large-Cell, Anaplastic
Disease, Hodgkin
Neoplasms
Carcinomas
Lymphoma, Non-Hodgkin

Interventions: Drug: ketoconazole
Drug: brentuximab vedotin
Drug: rifampin
Drug: midazolam

First Posted Date: 2009-12-04

Last Posted Date: 2014-12-18

Lead Sponsor: Seagen Inc.

Target Recruit Count: 73

Registration Number: NCT01026415

Locations: 🇺🇸
City of Hope, Duarte, California, United States
🇺🇸
Karmanos Cancer Institute / Wayne State University, Detroit, Michigan, United States
🇺🇸
St. Francis Medical Group Oncology & Hematology Specialists, Indianapolis, Indiana, United States

and more 3 locations

Drug Development Updates

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