Midazolam

Generic Name: Midazolam

Brand Names: Buccolam, Busulfex, Nayzilam, Seizalam

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₁₃ClFN_₃

CAS Number: 59467-70-8

Unique Ingredient Identifier: R60L0SM5BC

Background: Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called benzodiazepines. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Midazolam is available by oral, rectal, intranasal...

Indication: Midazolam has different indications depending on its formulation by the FDA.

Nasal
...

Associated Conditions: Epileptic seizure, Status Epilepticus

Associated Therapies: Anaesthesia, Anxiolytic therapy therapy, Sedation for mechanically-ventilated patients, Preoperative amnesia therapy, Preoperative sedation therapy

Clinical Trials

Dexmedetomidine Sedation With Third Molar Surgery

Phase 4

Terminated

Conditions: Anesthesia

Interventions: Drug: Dexmedetomidine
Drug: Midazolam
Drug: Ketamine

First Posted Date: 2009-11-20

Last Posted Date: 2013-06-17

Lead Sponsor: University of North Carolina, Chapel Hill

Target Recruit Count: 18

Registration Number: NCT01017237

Locations: 🇺🇸
University of North Carolina School of Dentistry, Chapel Hill, North Carolina, United States

The Effect of High-dose Remifentanil on Established Sunburn-induced Hyperalgesia in Human Volunteers (HighDose RemiSun)

Phase 4

Conditions: Hyperalgesia

Interventions: Drug: Midazolam
Drug: Remifentanil

First Posted Date: 2009-11-18

Last Posted Date: 2009-11-18

Lead Sponsor: Medical University of Vienna

Target Recruit Count: 24

Registration Number: NCT01015482

Locations: 🇦🇹
Department of Anaesthesia, Medical University of Vienna, Vienna, Austria

Study to Assess the Effect of BMS-791325 on the Pharmacokinetics of Midazolam in Healthy Subjects

Phase 1

Completed

Conditions: Hepatitis C

Interventions: Drug: Midazolam
Drug: BMS-791325

First Posted Date: 2009-10-16

Last Posted Date: 2014-05-06

Lead Sponsor: Bristol-Myers Squibb

Target Recruit Count: 48

Registration Number: NCT00996879

Locations: 🇺🇸
Wcct Global, Llc, Cypress, California, United States

Validation Study of Multiple Probe Compounds for Drug Interaction Evaluation

Phase 1

Completed

Conditions: Drug Interactions

Interventions: Drug: Caffeine
Drug: Ketoconazole
Drug: Rosiglitazone
Drug: Fluconazole
Drug: Flurbiprofen
Drug: Rifampin
Drug: Omeprazole
Drug: Dextromethorphan
Drug: Midazolam
Drug: Rosuvastatin

First Posted Date: 2009-08-24

Last Posted Date: 2018-01-04

Lead Sponsor: GlaxoSmithKline

Target Recruit Count: 87

Registration Number: NCT00964106

Locations: 🇰🇷
GSK Investigational Site, Seoul, Korea, Republic of

Study Evaluating the Effect of Desvenlafaxine on the Pharmacokinetics of Midazolam

Phase 4

Completed

Conditions: Major Depressive Disorder

Interventions: Drug: Desvenlafaxine Succinate Sustained Release
Drug: Midazolam

First Posted Date: 2009-08-06

Last Posted Date: 2011-08-15

Lead Sponsor: Pfizer

Target Recruit Count: 28

Registration Number: NCT00952653

Locations: 🇺🇸
Pfizer Investigational Site, New Haven, Connecticut, United States

Treatment Study of Bipolar Depression

Phase 4

Terminated

Conditions: Bipolar Disorder

Interventions: Drug: ketamine
Drug: midazolam

First Posted Date: 2009-07-28

Last Posted Date: 2017-05-17

Lead Sponsor: Icahn School of Medicine at Mount Sinai

Target Recruit Count: 1

Registration Number: NCT00947791

Locations: 🇺🇸
Mount Sinai School of Medicine, New York, New York, United States

Midazolam Sedation for Neonatal Lumbar Puncture

Phase 2

Terminated

Conditions: Pain
Anxiety

Interventions: Drug: Midazolam

First Posted Date: 2009-07-21

Last Posted Date: 2014-05-06

Lead Sponsor: Rambam Health Care Campus

Target Recruit Count: 12

Registration Number: NCT00942539

Locations: 🇮🇱
Rambam Health Care Campus, Haifa, Israel

The Effect of Etomidate on Outcomes of Trauma Patients

Not Applicable

Withdrawn

Conditions: Trauma

Interventions: Drug: Midazolam
Drug: Etomidate

First Posted Date: 2009-07-14

Last Posted Date: 2011-12-01

Lead Sponsor: Advocate Hospital System

Registration Number: NCT00938990

Does Distraction With a Hand Held Video Game Reduce Preoperative and Emergence Anxiety in Children?

Not Applicable

Completed

Conditions: Pediatric Emergence Agitation and Pain

Interventions: Device: Game Boy
Drug: Midazolam

First Posted Date: 2009-07-03

Last Posted Date: 2009-07-03

Lead Sponsor: University of Medicine and Dentistry of New Jersey

Target Recruit Count: 119

Registration Number: NCT00932685

Locations: 🇺🇸
University Hospital, Newark, New Jersey, United States

Drug Interaction Study of Darunavir/Ritonavir and Lopinavir/Ritonavir on GSK2248761 PK and CYP450 Probe Drugs

Phase 1

Completed

Conditions: Healthy Subjects
Infection, Human Immunodeficiency Virus

Interventions: Drug: lopinavir/ritonavir
Drug: darunavir/ritonavir
Drug: GSK2248761
Drug: Midazolam
Drug: Dextromethorphan
Drug: Flurbiprofen

First Posted Date: 2009-06-15

Last Posted Date: 2010-11-03

Lead Sponsor: GlaxoSmithKline

Target Recruit Count: 24

Registration Number: NCT00920088

Locations: 🇺🇸
GSK Investigational Site, Baltimore, Maryland, United States

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