Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

Safety of Driving After Minor Surgery with Monitored Anesthesia Care

Phase 4

Active, not recruiting

Conditions: Minor Surgical Procedures with Monitored Anesthesia Care
Driving Performance After Minor Ambulatory Surgery

Interventions: Drug: Midazolam
Drug: Sufentanil
Drug: Propofol

First Posted Date: 2007-12-20

Last Posted Date: 2024-12-05

Lead Sponsor: Rush University Medical Center

Target Recruit Count: 625

Registration Number: NCT00577200

Locations: 🇺🇸
Rush University Medical Center, Chicago, Illinois, United States

Propofol's Hypnotic and Memory Effects

Completed

Conditions: Healthy

Interventions: Drug: Placebo solution
Drug: propofol

First Posted Date: 2007-12-19

Last Posted Date: 2016-05-06

Lead Sponsor: Memorial Sloan Kettering Cancer Center

Target Recruit Count: 102

Registration Number: NCT00576615

Locations: 🇺🇸
Memorial Sloan Kettering Cancer Center, New York, New York, United States

Comparison Between Nurse-Administered Propofol Sedation and Diazemuls / Pethidine in Outpatient Colonoscopy

Not Applicable

Completed

Conditions: Colonoscopy

Interventions: Drug: diazemuls, pethidine
Drug: Propofol and Alfentanil

First Posted Date: 2007-12-03

Last Posted Date: 2007-12-03

Lead Sponsor: North District Hospital

Target Recruit Count: 194

Registration Number: NCT00566683

Sugammadex After Continuous Infusion of Rocuronium During Sevoflurane and Propofol Anesthesia (P05949; MK-8616-028)

Phase 3

Completed

Conditions: Anesthesia, General

Interventions: Drug: Sugammadex
Drug: Rocuronium
Drug: Sevoflurane
Drug: Propofol

First Posted Date: 2007-11-16

Last Posted Date: 2019-11-25

Lead Sponsor: Merck Sharp & Dohme LLC

Target Recruit Count: 52

Registration Number: NCT00559468

Intravenous Anesthesia Versus Anesthesia With Volatile Agents in Elective Craniotomy for Tumors

Not Applicable

Withdrawn

Conditions: Brain Neoplasms

Interventions: Drug: Propofol + Remifentanil
Drug: Sevoflurane + Remifentanil

First Posted Date: 2007-11-09

Last Posted Date: 2017-04-20

Lead Sponsor: The Cleveland Clinic

Registration Number: NCT00555984

Locations: 🇺🇸
Cleveland Clinic Foundation, Cleveland, Ohio, United States

Evaluate the Use of Paravertebral Block in Reconstructive Breast Surgery

Phase 3

Completed

Conditions: Breast Cancer

Interventions: Procedure: Paravertebral Block
Drug: Propofol
Drug: Ropivacaine
Drug: Fentanyl
Drug: Midazolam

First Posted Date: 2007-10-11

Last Posted Date: 2015-04-13

Lead Sponsor: M.D. Anderson Cancer Center

Target Recruit Count: 89

Registration Number: NCT00542542

Locations: 🇺🇸
UT MD Anderson Cancer Center, Houston, Texas, United States

COGNITIVE - Cognitive Function After Sevoflurane or Propofol Anesthesia for Open-heart Operations

Phase 4

Withdrawn

Conditions: Other Functional Disturbances Following Cardiac Surgery
Memory Disorders

Interventions: Drug: Diprivan (propofol, Astra Zeneca)
Drug: Sevorane (sevoflurane, Abbott)

First Posted Date: 2007-10-10

Last Posted Date: 2015-10-28

Lead Sponsor: Medical University of Gdansk

Registration Number: NCT00541918

Locations: 🇵🇱
Department of Cardiac Anesthesiology, Medical University of Gdańsk, Gdańsk, Poland
🇵🇱
Medical Universty of Gdańsk, Department of Cardiac and Vascular Surgery, Gdańsk, Poland