Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions: -

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

Esmolol Pretreatment on Pain During Injection of Propofol

Not Applicable

Completed

Conditions: Pain

Interventions: Drug: Normal saline
Drug: Esmolol
Drug: Remifentanil
Drug: propofol

First Posted Date: 2013-06-25

Last Posted Date: 2016-02-08

Lead Sponsor: Kyungpook National University Hospital

Target Recruit Count: 120

Registration Number: NCT01885364

Locations: 🇰🇷
Kyungpook National University Hospital, Daegu, Korea, Republic of

Intrathecal Levobupivacaine With Opioids for Caesarean Section

Phase 3

Completed

Conditions: Elective Caesarean Section Surgeries

Interventions: Drug: Control Group Chirocaine
Drug: Group Fentanyl
Drug: Group sufentanil
Drug: Ephedrine
Drug: Atropine sulfate
Drug: Propofol
Drug: Metoclopramide
Drug: Diphenhydramine
Drug: pethidine hydrochloride
Drug: Diclofenac sodium

First Posted Date: 2013-05-21

Last Posted Date: 2013-05-21

Lead Sponsor: Baskent University

Target Recruit Count: 93

Registration Number: NCT01858090

Locations: 🇹🇷
Baskent University School of Medicine Adana Teaching and Research Hospital, Adana, Turkey

Therapeutic Equivalence (TE) Study of Propofol 2% MCT Fresenius (MCT=Medium-Chain Triglycerides) Compared With Diprivan® in Patients Undergoing Elective Surgery

Phase 3

Completed

Conditions: General Anesthesia
Elective Surgery

Interventions: Drug: Diprivan
Drug: Propofol

First Posted Date: 2013-05-20

Last Posted Date: 2014-02-21

Lead Sponsor: Fresenius Kabi

Target Recruit Count: 71

Registration Number: NCT01856998

Locations: 🇫🇷
CHU de Bordeaux, Groupe Hospitalier Pellegrin, Bordeaux, France

Dexmedetomidine for Laryngeal Mask Airway Insertion

Phase 4

Completed

Conditions: Drug Usage

Interventions: Drug: dexmedetomidine
Drug: propofol
Device: laryngeal mask airway (LMA)

First Posted Date: 2013-05-13

Last Posted Date: 2014-04-22

Lead Sponsor: Ajou University School of Medicine

Target Recruit Count: 22

Registration Number: NCT01852539

Locations: 🇰🇷
Ajou University School of Medicine, Suwon, Korea, Republic of

Comparison of Intravenous Anesthetics to Volatile Anesthetics on Postoperative Cognitive Dysfunction

Phase 4

Completed

Conditions: Intra-abdominal and Intrapelvic Surgery

Interventions: Drug: Sevoflurane
Drug: propofol
Drug: remifentanil

First Posted Date: 2013-03-12

Last Posted Date: 2023-06-22

Lead Sponsor: Sun Yat-sen University

Target Recruit Count: 684

Registration Number: NCT01809041

Locations: 🇨🇳
Sun Yat-Sen Memorial Hospital, Guangzhou, Guangdong, China

Effect of Propofol on Internal Anal Sphincter Pressure During ARM

Completed

Conditions: Chronic Constipation

Interventions: Drug: Propofol

First Posted Date: 2013-02-18

Last Posted Date: 2016-09-14

Lead Sponsor: Massachusetts General Hospital

Target Recruit Count: 20

Registration Number: NCT01793753

Locations: 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States

Prophylactic Subhypnotic Propofol for Nausea and Vomiting During for Cesarean Section Under Subarachnoid Anesthesia.

Phase 4

Completed

Conditions: PREGNANCY

Interventions: Drug: PLACEBO
Drug: METOCLOPRAMIDE
Drug: PROPOFOL

First Posted Date: 2013-02-01

Last Posted Date: 2014-12-16

Lead Sponsor: G. d'Annunzio University

Target Recruit Count: 112

Registration Number: NCT01781377

Locations: 🇮🇹
A.O. SS.ma Annunziata, Chieti, Italy

The Effects of Anesthesia on Patients Undergoing Surgery for Repair of a Thoracoabdominal Aneurysm.

Not Applicable

Terminated

Conditions: Aneurysm Stent
Cardiopulmonary Bypass
Abdominal Aneurysm
Thoracic Aneurysm

Interventions: Drug: isoflurane
Drug: Propofol

First Posted Date: 2013-01-21

Last Posted Date: 2017-03-31

Lead Sponsor: Johns Hopkins University

Target Recruit Count: 14

Registration Number: NCT01772537

Locations: 🇺🇸
Johns Hopkins Hospital, Baltimore, Maryland, United States

Three Anaesthesic Method in Electroconvulsive Theraphy

Phase 4

Completed

Conditions: Anesthesia

Interventions: Drug: Propofol
Drug: Remifentanil and propofol
Drug: Sevoflurane

First Posted Date: 2013-01-03

Last Posted Date: 2013-01-03

Lead Sponsor: Inonu University

Target Recruit Count: 39

Registration Number: NCT01759589

Locations: 🇹🇷
Turgut Ozal Medical Center, Malatya, Turkey

Propofol Versus Sevoflurane Recovery After Gynecological Surgery

Phase 4

Completed

Conditions: Anesthesia
Surgery

Interventions: Drug: Propofol
Drug: Sevoflurane

First Posted Date: 2012-12-24

Last Posted Date: 2016-03-14

Lead Sponsor: Northwestern University

Target Recruit Count: 90

Registration Number: NCT01755234

Locations: 🇺🇸
Prentice Women's Hospital, Chicago, Illinois, United States

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