Flurbiprofen

Background: Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically prior to ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen.

Indication: Flurbiprofen tablets are indicated for the acute or long-term symptomatic treatment of rheumatoid arthritis, osteorarthritis and anklosing spondylitis. It may also be used to treat pain associated with dysmenorrhea and mild to moderate pain accompanied by inflammation (e.g. bursitis, tendonitis, soft tissue trauma). Topical ophthalmic formulations may be used pre-operatively to prevent intraoperative miosis.

Associated Conditions: Ankylosing Spondylitis (AS), Back Pain, Acute, Chronic Back Pain, Menstrual Distress (Dysmenorrhea), Muscle Spasms, Non-Articular Rheumatic Muscle Spasms, Osteoarthritis (OA), Pain, Pain, Inflammatory, Post Traumatic Pain, Postoperative pain, Rheumatoid Arthritis, Spinal pain

Drug Interaction Study of Darunavir/Ritonavir and Lopinavir/Ritonavir on GSK2248761 PK and CYP450 Probe Drugs

Phase 1

Completed

Interventions: Drug: darunavir/ritonavir
Drug: lopinavir/ritonavir
Drug: GSK2248761
Drug: Midazolam
Drug: Dextromethorphan
Drug: Flurbiprofen

Phase 2

Completed

Interventions: Drug: Flurbiprofen Tape (Arm 2)
Drug: Flurbiprofen Tape (Arm 4)
Drug: Placebo Tape (Arm 1)
Drug: Placebo Tape (Arm 3)

Locations: 🇺🇸
Sarah Cannon Research Institute, Memphis, Tennessee, United States
🇺🇸
Internal Medicine Associates of Cordova, Cordova, Tennessee, United States
🇺🇸
Rainier Clinical Research Center, Inc., Renton, Washington, United States