Flurbiprofen
- Generic Name
- Flurbiprofen
- Drug Type
- Small Molecule
- Chemical Formula
- C15H13FO2
- CAS Number
- 5104-49-4
- Unique Ingredient Identifier
- 5GRO578KLP
- Background
Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically prior to ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen.
- Indication
Flurbiprofen tablets are indicated for the acute or long-term symptomatic treatment of rheumatoid arthritis, osteorarthritis and anklosing spondylitis. It may also be used to treat pain associated with dysmenorrhea and mild to moderate pain accompanied by inflammation (e.g. bursitis, tendonitis, soft tissue trauma). Topical ophthalmic formulations may be used pre-operatively to prevent intraoperative miosis.
- Associated Conditions
- Ankylosing Spondylitis (AS), Back Pain, Acute, Chronic Back Pain, Menstrual Distress (Dysmenorrhea), Muscle Spasms, Non-Articular Rheumatic Muscle Spasms, Osteoarthritis (OA), Pain, Pain, Inflammatory, Post Traumatic Pain, Postoperative pain, Rheumatoid Arthritis, Spinal pain
Perioperative Analgesia Modes in Minimally Invasive Esophagectomy
- Conditions
- Patient-controlled AnalgesiaNSAIDsOpioidEsophageal CancerPerioperative Analgesia
- Interventions
- Device: Patient-controlled analgesia pump
- First Posted Date
- 2022-08-17
- Last Posted Date
- 2025-03-20
- Target Recruit Count
- 102
- Registration Number
- NCT05504265
- Locations
- 🇨🇳
Cancer Hospital Chinese Academy of Medical Sciences, Beijing, China
A Study to Investigate the Effect of Single and Repeated Oral Doses of ACT-539313 on What the Body Does to Flurbiprofen, Omeprazole, Midazolam in Healthy Subjects
- Conditions
- Healthy
- Interventions
- First Posted Date
- 2022-02-24
- Last Posted Date
- 2022-05-04
- Lead Sponsor
- Idorsia Pharmaceuticals Ltd.
- Target Recruit Count
- 22
- Registration Number
- NCT05254548
- Locations
- 🇩🇪
CRS Clinical Research Services Berlin GmbH, Berlin, Germany
Chinese Tuina Therapy for Treatment of Chronic Nonspecific Low Back Pain
- Conditions
- Chronic Nonspecific Low Back Pain
- Interventions
- Behavioral: Chinese Tuina therapy
- First Posted Date
- 2021-07-26
- Last Posted Date
- 2022-01-04
- Lead Sponsor
- Beijing University of Chinese Medicine
- Target Recruit Count
- 90
- Registration Number
- NCT04976790
- Locations
- 🇨🇳
Beiing university of Chinese medicine Dongzhimen Hospital, Beijing, Beijing, China
Oro-tracheal Intubation: Flurbiprofen Subglottic Instillation to Prevent Laryngeal Inflammation
- First Posted Date
- 2021-01-14
- Last Posted Date
- 2021-01-14
- Target Recruit Count
- 70
- Registration Number
- NCT04708964
Bioequivalence of Flurbiprofen Lozenge vs Strepfen
- Conditions
- Healthy
- Interventions
- First Posted Date
- 2020-12-17
- Last Posted Date
- 2020-12-17
- Lead Sponsor
- Aziende Chimiche Riunite Angelini Francesco S.p.A
- Target Recruit Count
- 24
- Registration Number
- NCT04670601
- Locations
- 🇨🇭
CROSS Research S.A., Phase I Unit, Arzo, Switzerland
Drug-drug Interaction Study of KL1333 in Healthy Subjects
- Conditions
- Mitochondrial Disease
- Interventions
- First Posted Date
- 2020-11-25
- Last Posted Date
- 2021-10-20
- Lead Sponsor
- Abliva AB
- Target Recruit Count
- 14
- Registration Number
- NCT04643249
- Locations
- 🇬🇧
Volunteer recruitment center Covance Leeds Covance Leeds, Leeds, United Kingdom
Effect of Preemptive Analgesia With Flurbiprofen Axetil on Perioperative Sleep Quality and Postoperative Pain in Patients Undergoing Sevoflurane Inhalation.
- Conditions
- Flurbiprofen AxetilPreemptive AnalgesiaPostoperative PainPerioperative Sleep QualityPostoperative Inflammatory Markers
- Interventions
- First Posted Date
- 2020-11-02
- Last Posted Date
- 2022-01-10
- Lead Sponsor
- Beijing Friendship Hospital
- Target Recruit Count
- 100
- Registration Number
- NCT04611763
- Locations
- 🇨🇳
beijing friendship hospital of Capital Medical university, Beijing, China
Remimazolam Tosilate Sedation and Midazolam Sedation in Dental Patients
- Conditions
- RemimazolamSedation ComplicationMidazolam
- Interventions
- First Posted Date
- 2020-10-26
- Last Posted Date
- 2022-03-15
- Lead Sponsor
- Peking University
- Target Recruit Count
- 81
- Registration Number
- NCT04602845
- Locations
- 🇨🇳
Peking University Hospital of Stomatology, Beijing, Beijing, China
🇨🇳Zijian Guo, Haidian, Beijing, China
Evaluation of Pharmacokinetic Interaction Between GSK3640254 and Caffeine, Metoprolol, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin in Healthy Adults
- Conditions
- HIV Infections
- Interventions
- First Posted Date
- 2020-06-11
- Last Posted Date
- 2024-01-05
- Lead Sponsor
- ViiV Healthcare
- Target Recruit Count
- 20
- Registration Number
- NCT04425902
- Locations
- 🇺🇸
GSK Investigational Site, Las Vegas, Nevada, United States
Evaluation of the Effects of Different Analgesics on Pericoronitis Pain and Quality of Life
- Conditions
- Quality of LifePain
- Interventions
- First Posted Date
- 2018-11-19
- Last Posted Date
- 2018-11-19
- Lead Sponsor
- Near East University, Turkey
- Target Recruit Count
- 60
- Registration Number
- NCT03745599
- Locations
- 🇹🇷
Abdullah AlAlwani, Mersin, Turkey
Drug Development Updates
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