Tranylcypromine
- Generic Name
- Tranylcypromine
- Brand Names
- Parnate
- Drug Type
- Small Molecule
- Chemical Formula
- C9H11N
- CAS Number
- 155-09-9
- Unique Ingredient Identifier
- 3E3V44J4Z9
- Background
A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders (From AMA Drug Evaluations Annual, 1994, p311).
Tranylcypromine is a racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1-amine with the chiral centers both located on the cylopropane ring. An irreversible monoamine oxidase inhibitor that is used as an antidepressant (INN tranylcypromine).
- Indication
用于抑郁症。
- Associated Conditions
- Depressive Episodes
Sequential Tranylcypromine (TC), TC + Dextroamphetamine and TC + Triiodothyronine for Refractory Depression
- Conditions
- Major Depression
- Interventions
- First Posted Date
- 2006-02-27
- Last Posted Date
- 2012-04-27
- Lead Sponsor
- New York State Psychiatric Institute
- Target Recruit Count
- 31
- Registration Number
- NCT00296686
- Locations
- 🇺🇸
Depression Evaluation Service - New York State Psychiatric Institute, New York, New York, United States
Treatment of Orthostatic Hypotension in Autonomic Failure
- Conditions
- Autonomic FailureOrthostatic Hypotension
- Interventions
- Drug: placeboDevice: inflatable abdominal binder (sham)Other: water intakeDietary Supplement: BovrilDevice: Inflatable abdominal binder
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2017-01-18
- Lead Sponsor
- Vanderbilt University
- Target Recruit Count
- 389
- Registration Number
- NCT00223691
- Locations
- 🇺🇸
Vanderbilt University, Nashville, Tennessee, United States
Treatment of Geriatric Bipolar Mood Disorders: A Pilot Study
- Conditions
- Bipolar Disorder
- First Posted Date
- 2005-09-15
- Last Posted Date
- 2005-09-15
- Lead Sponsor
- University of Pittsburgh
- Target Recruit Count
- 60
- Registration Number
- NCT00177567
- Locations
- 🇺🇸
University of Pittsubrgh Medical Center, Pittsburgh, Pennsylvania, United States
🇺🇸University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
Sequenced Treatment Alternatives to Relieve Depression (STAR*D)
- Conditions
- Depression
- First Posted Date
- 2001-07-23
- Last Posted Date
- 2009-09-25
- Lead Sponsor
- National Institute of Mental Health (NIMH)
- Target Recruit Count
- 4000
- Registration Number
- NCT00021528
- Locations
- 🇺🇸
Harbor UCLA Family Health Care Center, Harbor City, California, United States
🇺🇸UCLA General Outpatient Psychiatry Clinic, Los Angeles, California, United States
🇺🇸UCLA Internal Medicine Clinic, Los Angeles, California, United States
Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
- Conditions
- Bipolar Disorder
- First Posted Date
- 2001-03-15
- Last Posted Date
- 2007-05-04
- Lead Sponsor
- National Institute of Mental Health (NIMH)
- Target Recruit Count
- 5000
- Registration Number
- NCT00012558
- Locations
- 🇺🇸
Case Western Reserve University, Cleveland, Ohio, United States
🇺🇸University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, United States
🇺🇸University of Pittsburgh, Pittsburgh, Pennsylvania, United States
Drug Development Updates
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