Chlorhexidine

Generic Name: Chlorhexidine

Brand Names: Betasept, Hibiclens, Instillagel, Nupro Chlorhexidine, Oris, Oro-Clense, Paroex, Perichlor, Peridex, Periochip, Periogard, Prevora, X-pur

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₃₀Cl_₂N_₁₀

CAS Number: 55-56-1

Unique Ingredient Identifier: R4KO0DY52L

Background: Chlorhexidine is a broad-spectrum antimicrobial biguanide used as a topical antiseptic and in dental practice for the treatment of inflammatory dental conditions caused by microorganisms. It is one of the most common skin and mucous membrane antiseptic agents in use today. The molecule itself is a cationic bis-guanide consisting of two 4-chlorophenyl rings a...

Indication: Chlorhexidine is available over-the-counter in various formulations (e.g. solution, sponge, cloth, swab) as a topical antiseptic to sanitize prior to surgeries and/or medical procedures. Dental formulations, available by prescription only, include an oral rinse indicated for the treatment of gingivitis and a slow-release "chip" which is inserted into periodo...

Associated Conditions: Aphthous ulcer, Catarrh of the throat, Chemotherapy Induced Oral Mucositis, Chronic Wounds, Decubitus Ulcer, Dental Cavity, Dysphagia, Eczema infected, Foeter Ex Ore, Gingival Bleeding, Gingival Diseases, Gingivitis, Glossitis, Hoarseness, Infection, Infectious Periodontal Diseases, Injury Throat, Mild to Moderate Inflammatory Reaction of the Oral Cavity, Mild to Moderate Inflammatory Reaction of the Pharynx, Mouth injury, Mucositis, Neurodermatitis, Ocular Inflammation, Ocular Irritation, Oral Aphthous Ulcer, Pain, Periodontitis, Pharyngitis, Plaque, Dental, Postoperative Wound Infection, Purulent Gingivitis, Radiation Mucositis, Red eye, Ringworm, Skin Infections, Sore Throat, Stomatitis, Surgical Wounds, Tissue Damage, Tonsillitis, Ulcers, Leg, Wound Infections, Bacterial skin infections, Dry, cracked skin, Gum pain, Moderate Gingivitis, Oral infections, Oral lesions, Recurrent Oral fungal infection, Severe Gingivitis, Superficial Wounds, Throat disinfection, Tongue inflammation

Associated Therapies: Anesthesia of Mucous Membrane, Antimicrobial Therapy, Contact Lens Care, Disinfection, Disinfection of External Genitalia, Disinfection of the Urethra, Disinfection of the Vaginal Mucosa, Irrigation therapy, Lubrication of the Urethra, Oral Care, Oral Hygiene, Oropharyngeal antisepsis, Promotion of wound healing, Skin disinfection, Surgical Scrubbing, Topical Antisepsis, Urethral Anesthesia, Wound Cleansing, Oral antisepsis, Oral disinfection

Clinical Trials

Prehospital Ventilator-Associated Pneumonia Prevention Trial

Completed

Conditions: Wounds and Injuries
Respiratory Failure
Pneumonia, Ventilator-Associated

Interventions: Drug: Chlorhexidine gluconate

First Posted Date: 2013-07-18

Last Posted Date: 2017-06-09

Lead Sponsor: Nicholas M Mohr

Target Recruit Count: 70

Registration Number: NCT01902446

Locations: 🇺🇸
University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States

Umbilical Cord Care for the Prevention of Colonization

Not Applicable

Conditions: Line Insertion Site
Central Line-associated Bloodstream Infection (CLABSI)

Interventions: Drug: Chlorhexidine gluconate
Drug: Pluronic Cream
Other: control
Drug: Povidone-Iodine

First Posted Date: 2013-07-08

Last Posted Date: 2013-08-02

Lead Sponsor: University of Virginia

Target Recruit Count: 100

Registration Number: NCT01893060

Locations: 🇺🇸
University of Virginia HealthSystem, Charlottesville, Virginia, United States

Topical Umbilical Cord Care for the Prevention of Colonization and Invasive Infections

Not Applicable

Completed

Conditions: Colonization

Interventions: Drug: Pluronic
Other: Control
Drug: Chlorhexidine
Drug: Povidone-Iodine

First Posted Date: 2013-06-25

Last Posted Date: 2018-05-03

Lead Sponsor: University of Virginia

Target Recruit Count: 53

Registration Number: NCT01886001

Locations: 🇺🇸
Univeristy of Virginia Health System, Charlottesville, Virginia, United States

Comparison of Surgical Skin Preps During Cesarean Deliveries

Not Applicable

Completed

Conditions: Surgical Site Infection Following Cesarean Delivery

Interventions: Drug: Combination iodine and chlorhexidine
Drug: Iodine povidone
Drug: Chlorhexidine

First Posted Date: 2013-06-06

Last Posted Date: 2017-10-02

Lead Sponsor: Montefiore Medical Center

Target Recruit Count: 1404

Registration Number: NCT01870583

Locations: 🇺🇸
Montefiore Medical Center Weiler Division, The Bronx, New York, United States
🇺🇸
Montefiore Medical Center Wakefield Division, The Bronx, New York, United States