Amiodarone
- Generic Name
- Amiodarone
- Brand Names
- Nexterone, Pacerone
- Drug Type
- Small Molecule
- Chemical Formula
- C25H29I2NO3
- CAS Number
- 1951-25-3
- Unique Ingredient Identifier
- N3RQ532IUT
- Background
Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxicity and possibly death, amiodarone use s...
- Indication
The FDA approved indications for amiodarone are recurrent ventricular fibrillation (VF) and recurrent hemodynamically unstable ventricular tachycardia (VT). The FDA emphasizes that this drug should only be given in these conditions when they are clinically documented and have not responded to normal therapeutic doses of other antiarrhythmic agents, or when o...
- Associated Conditions
- Atrial Fibrillation, Supraventricular Tachycardia (SVT), Recurrent Ventricular fibrillation, Recurrent hemodynamically unstable Ventricular tachycardia
- Associated Therapies
- -
Amiodarone Against ICD Therapy in Chagas Cardiomyopathy for Primary Prevention of Death
- First Posted Date
- 2012-11-07
- Last Posted Date
- 2021-08-30
- Lead Sponsor
- InCor Heart Institute
- Target Recruit Count
- 1100
- Registration Number
- NCT01722942
- Locations
- 🇧🇷
Hospital das Clínicas de Goiania, Goiania, GO, Brazil
🇧🇷Hospital Geral Universitário, Cuiabá, Mount, Brazil
🇧🇷Santa Casa de Ribeirão Preto, Ribeirão Preto, SP, Brazil
Comparison of Treatment of Atrial Fibrillation (AF) Between Surgical Ultrasonic Technology or Drug Therapy for Patients With AF Requiring Mitral Valve Surgery
- Conditions
- Interventions
- First Posted Date
- 2012-07-25
- Last Posted Date
- 2015-12-02
- Target Recruit Count
- 6
- Registration Number
- NCT01649544
- Locations
- 🇫🇷
CHU de Saint-Etienne, Saint-etienne, France
🇫🇷CHU de Grenoble, Grenoble, France
🇫🇷Hospices Civiles de Lyon, Lyon, France
A Study Comparing Vernakalant Therapy to Amiodarone Therapy in Acute Management of Recent Onset Atrial Fibrillation (AF) (MK-6621-055)
- First Posted Date
- 2012-06-25
- Last Posted Date
- 2013-08-26
- Lead Sponsor
- Advanz Pharma
- Registration Number
- NCT01627106
Pilot Study of Catheter Ablation for Ventricular Tachycardia in Patients With an Implantable Cardioverter Defibrillator
- Conditions
- Interventions
- First Posted Date
- 2012-04-12
- Last Posted Date
- 2014-10-16
- Lead Sponsor
- Duke University
- Target Recruit Count
- 27
- Registration Number
- NCT01576042
- Locations
- 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States
🇺🇸Ohio State University Medical Center, Columbus, Ohio, United States
🇺🇸University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
Combined Amiodarone and Electrical Cardioversion for Postoperative Atrial Fibrillation After Cardiac Surgery
- Conditions
- Interventions
- First Posted Date
- 2012-03-20
- Last Posted Date
- 2017-05-23
- Lead Sponsor
- Weill Medical College of Cornell University
- Target Recruit Count
- 1
- Registration Number
- NCT01558128
- Locations
- 🇺🇸
Weill Cornell Medical College, New York, New York, United States
Atrial Fibrillation Without Hemodynamic Instability in the Intensive Care Unit
- First Posted Date
- 2011-10-28
- Last Posted Date
- 2014-09-15
- Lead Sponsor
- Ottawa Hospital Research Institute
- Target Recruit Count
- 25
- Registration Number
- NCT01461733
Minocycline Plus Amiodarone Versus Amiodarone Alone for the Prevention of Atrial Fibrillation After Cardiac Surgery
- Conditions
- Interventions
- First Posted Date
- 2011-08-23
- Last Posted Date
- 2024-08-06
- Lead Sponsor
- Baystate Medical Center
- Target Recruit Count
- 60
- Registration Number
- NCT01422148
- Locations
- 🇺🇸
Abdallah Alameddine, Melrose, Massachusetts, United States
Amiodarone, Lidocaine or Neither for Out-Of-Hospital Cardiac Arrest Due to Ventricular Fibrillation or Tachycardia
- Conditions
- Interventions
- First Posted Date
- 2011-07-25
- Last Posted Date
- 2017-04-17
- Lead Sponsor
- University of Washington
- Target Recruit Count
- 3024
- Registration Number
- NCT01401647
- Locations
- 🇺🇸
Alabama Resuscitation Center, Birmingham, Alabama, United States
🇺🇸Portland Resuscitation Outcomes Consortium, Oregon Health & Sciences University, Portland, Oregon, United States
🇨🇦University of Ottawa/University of British Columbia Collaborative RCC, Ottawa Health Research, Ottawa, Ontario, Canada
Pulmonary Vein Ablation Versus Amiodarone in the Elderly
- Conditions
- Interventions
- First Posted Date
- 2011-01-13
- Last Posted Date
- 2015-12-30
- Lead Sponsor
- Abbott Medical Devices
- Target Recruit Count
- 59
- Registration Number
- NCT01276093
- Locations
- 🇳🇱
Maxima Medical Center, Veldhoven, Noord Brabant, Netherlands
🇳🇱Haga Hospital, Den Haag, Zuid Holland, Netherlands
🇳🇱Catharina Ziekenhuis, Eindhoven, Netherlands
Amiodarone Compared to Dronedarone , Post Cardioversion Maintenance of Sinus Rhythm
- First Posted Date
- 2010-12-24
- Last Posted Date
- 2010-12-24
- Lead Sponsor
- Eastbourne General Hospital
- Target Recruit Count
- 100
- Registration Number
- NCT01266681
- Locations
- 🇬🇧
Eastbourne General Hospital, Eastbourne, East Sussex, United Kingdom
Drug Development Updates
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