Amiodarone
- Generic Name
- Amiodarone
- Brand Names
- Nexterone, Pacerone
- Drug Type
- Small Molecule
- Chemical Formula
- C25H29I2NO3
- CAS Number
- 1951-25-3
- Unique Ingredient Identifier
- N3RQ532IUT
- Background
Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxicity and possibly death, amiodarone use s...
- Indication
The FDA approved indications for amiodarone are recurrent ventricular fibrillation (VF) and recurrent hemodynamically unstable ventricular tachycardia (VT). The FDA emphasizes that this drug should only be given in these conditions when they are clinically documented and have not responded to normal therapeutic doses of other antiarrhythmic agents, or when o...
- Associated Conditions
- Atrial Fibrillation, Supraventricular Tachycardia (SVT), Recurrent Ventricular fibrillation, Recurrent hemodynamically unstable Ventricular tachycardia
- Associated Therapies
- -
Amiodarone to Prevent Post-Operative Arrhythmias
- Conditions
- First Posted Date
- 2005-11-10
- Last Posted Date
- 2006-05-05
- Lead Sponsor
- University of Calgary
- Target Recruit Count
- 600
- Registration Number
- NCT00251706
- Locations
- 🇨🇦
Libin Cardiovascular Institute / University of Calgary, Calgary, Alberta, Canada
Prevention of Atrial Fibrillation Following Noncardiac Thoracic Surgery
- First Posted Date
- 2005-08-08
- Last Posted Date
- 2013-09-18
- Lead Sponsor
- Indiana University
- Target Recruit Count
- 130
- Registration Number
- NCT00127712
- Locations
- 🇺🇸
Indiana University, Indianapolis, Indiana, United States
Effects of Epinephrine and Intravenous (I.V.) Needle on Cardiopulmonary Resuscitation (CPR) Outcome
- Conditions
- Interventions
- First Posted Date
- 2005-07-21
- Last Posted Date
- 2015-05-29
- Lead Sponsor
- Petter Andreas Steen
- Target Recruit Count
- 904
- Registration Number
- NCT00121524
- Locations
- 🇳🇴
Ulleval University Hospital, Oslo, Norway
Comparing the Effects of Amiodarone, Sotalol, and Placebo in Maintaining Sinus Rhythm in Patients With Atrial Fibrillation Converted to Sinus Rhythm
- Conditions
- Interventions
- First Posted Date
- 2001-01-01
- Last Posted Date
- 2011-06-15
- Lead Sponsor
- US Department of Veterans Affairs
- Target Recruit Count
- 706
- Registration Number
- NCT00007605
- Locations
- 🇺🇸
VA Medical Center, Augusta, Augusta, Georgia, United States
🇺🇸VA North Texas Health Care System, Dallas, Dallas, Texas, United States
🇺🇸VA Medical Center, Minneapolis, Minneapolis, Minnesota, United States
Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM)
- Conditions
Cardiac Arrest in Seattle: Conventional Versus Amiodarone Drug Evaluation (CASCADE)
- Conditions
- First Posted Date
- 1999-10-28
- Last Posted Date
- 2013-07-29
- Lead Sponsor
- University of Washington
- Registration Number
- NCT00000464
Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT)
Drug Development Updates
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