Morphine
- Generic Name
- Morphine
- Brand Names
- Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex
- Drug Type
- Small Molecule
- Chemical Formula
- C17H19NO3
- CAS Number
- 57-27-2
- Unique Ingredient Identifier
- 76I7G6D29C
- Background
Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.
Morphine was granted FDA approval in 1941.
- Indication
Morphine is used for the management of chronic, moderate to severe pain.
Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.
- Associated Conditions
- Chronic Pain, Severe Pain
- Associated Therapies
- -
Evaluation of the Tolerability of Switching Subjects on Chronic ATC Opioid Therapy to Buprenorphine HCl Buccal Film
- Conditions
- Interventions
- First Posted Date
- 2013-06-06
- Last Posted Date
- 2017-02-27
- Lead Sponsor
- BioDelivery Sciences International
- Target Recruit Count
- 39
- Registration Number
- NCT01871285
- Locations
- 🇺🇸
CRI Lifetree (Lifetree Clinical Research), Salt Lake, Utah, United States
🇺🇸CRI Lifetree, Philadelphia, Pennsylvania, United States
🇺🇸Vince and Associates Clinical Research, Inc., Overland Park, Kansas, United States
Use of Intrathecal Hydromorphone in Elective Cesarean Deliveries
- First Posted Date
- 2013-05-31
- Last Posted Date
- 2019-01-03
- Lead Sponsor
- Grace Shih, MD
- Target Recruit Count
- 45
- Registration Number
- NCT01866254
- Locations
- 🇺🇸
University of Kansas Medical Center, Kansas City, Kansas, United States
Ultrasound-guided Blocks for Ambulatory Knee Arthroscopy
- First Posted Date
- 2013-04-23
- Last Posted Date
- 2013-11-06
- Lead Sponsor
- Jens Borglum Neimann
- Target Recruit Count
- 60
- Registration Number
- NCT01837394
- Locations
- 🇩🇰
Department of Anesthesiology, Bispebjerg Hospital, Copenhagen, Denmark
Low Dose Ketamine Versus Morphine for Moderate to Severe Pain in the Emergency Department
- First Posted Date
- 2013-04-18
- Last Posted Date
- 2016-02-29
- Lead Sponsor
- Antonios Likourezos
- Target Recruit Count
- 90
- Registration Number
- NCT01835262
- Locations
- 🇺🇸
Maimonides Medical Center, Brooklyn, New York, United States
Methadone for Postoperative Pain
- Conditions
- Interventions
- First Posted Date
- 2013-04-17
- Last Posted Date
- 2023-09-26
- Lead Sponsor
- Universidad de Valparaiso
- Target Recruit Count
- 86
- Registration Number
- NCT01833715
- Locations
- 🇨🇱
Almirante Nef Naval Hospital, Viña del Mar, Valparaiso, Chile
RANDOMISED STUDY OF EPIDURAL VS MPCA MORPHINE VS TAPP IN LAPAROSCOPIC SIGMOIDECTOMY
- First Posted Date
- 2013-04-08
- Last Posted Date
- 2013-04-08
- Lead Sponsor
- Corporacion Parc Tauli
- Target Recruit Count
- 225
- Registration Number
- NCT01825993
- Locations
- 🇪🇸
Corporacion Parc Tauli, Sabadell, Sabadell-barcelona, Spain
Parent/Nurse Controlled Analgesia in the Neonatal Intensive Care Unit
- First Posted Date
- 2013-04-04
- Last Posted Date
- 2020-09-02
- Lead Sponsor
- Medical College of Wisconsin
- Target Recruit Count
- 36
- Registration Number
- NCT01823497
- Locations
- 🇺🇸
Children's Hospital of Wisconsin, Milwaukee, Wisconsin, United States
Oral Oxycodone After Major Cardiac Surgery
- Conditions
- Interventions
- First Posted Date
- 2013-03-22
- Last Posted Date
- 2014-03-26
- Lead Sponsor
- Medical University of Vienna
- Target Recruit Count
- 50
- Registration Number
- NCT01816581
- Locations
- 🇦🇹
Medical University Vienna, Vienna, Austria
An Efficacy and Safety Study of Transdermal Therapeutic System (TTS)-Fentanyl in Thai Participants With Chronic Non-Malignant Pain
- First Posted Date
- 2013-03-22
- Last Posted Date
- 2014-04-28
- Lead Sponsor
- Janssen-Cilag Ltd.,Thailand
- Target Recruit Count
- 39
- Registration Number
- NCT01816243
- Locations
- 🇹🇭
Department of Anesthesia, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
RCT Comparing the Analgesic Efficacy of 4 Therapeutic Strategies Based on 4 Different Major Opioids (Fentanyl, Oxycodone, Buprenorphine vs Morphine) in Cancer Patients With Moderate/Severe Pain, at the Moment of Starting 3rd Step of WHO Analgesic Ladder.
- Conditions
- Interventions
- First Posted Date
- 2013-03-12
- Last Posted Date
- 2015-12-24
- Target Recruit Count
- 518
- Registration Number
- NCT01809106
- Locations
- 🇮🇹
Multimedica, Sesto San Giovanni, Italy
🇮🇹Istituto Scientifico San Raffaele, Milano, Italy
🇮🇹Arcispedale S. Maria Nuova Azienda Ospedaliera, Reggio Emilia, RE, Italy
Drug Development Updates
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