Morphine

Generic Name: Morphine

Brand Names: Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₁₉NO_₃

CAS Number: 57-27-2

Unique Ingredient Identifier: 76I7G6D29C

Background: Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.

Morphine was granted FDA approval in 1941.

Indication: Morphine is used for the management of chronic, moderate to severe pain.

Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.

Associated Conditions: Chronic Pain, Severe Pain

Associated Therapies: -

Clinical Trials

Measuring the Amount of Methadone or Morphine in the Blood of Neonates, Infants & Children After Cardiac Surgery.

Phase 1

Completed

Conditions: Pain

Interventions: Drug: Methadone
Drug: Morphine

First Posted Date: 2010-03-29

Last Posted Date: 2017-09-18

Lead Sponsor: Stanford University

Target Recruit Count: 47

Registration Number: NCT01094522

Locations: 🇺🇸
University of Colorado, Denver, Colorado, United States
🇺🇸
Oregon Health & Sciences University, Portland, Oregon, United States
🇺🇸
Stanford University School of Medicine, Stanford, California, United States

Effect of Dexmedetomidine on Gastric Emptying and Gastrointestinal Transit

Phase 1

Completed

Conditions: Gastric Emptying
Healthy

Interventions: Drug: Dexmedetomidine
Drug: Placebo
Drug: Morphine

First Posted Date: 2010-03-10

Last Posted Date: 2010-06-04

Lead Sponsor: University of Turku

Target Recruit Count: 12

Registration Number: NCT01084473

Locations: 🇫🇮
Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine, Turku University and Turku University Hospital, Turku, Finland

Study to Evaluate the Efficacy, Safety and Tolerability of N1539

Phase 2

Completed

Conditions: Hysterectomy

Interventions: Drug: N1539
Drug: placebo
Drug: Morphine

First Posted Date: 2010-03-10

Last Posted Date: 2011-12-02

Lead Sponsor: Alkermes, Inc.

Target Recruit Count: 486

Registration Number: NCT01084161

An Efficacy and Safety Study to Compare Morphine 6-glucuronide (M6G) and Morphine in Patients Suffering With Post-Operative Pain for at Least 24 Hours

Phase 3

Completed

Conditions: Postoperative Pain

Interventions: Drug: Morphine 6-glucuronide
Drug: Morphine

First Posted Date: 2010-03-08

Last Posted Date: 2023-08-29

Lead Sponsor: Paion UK Ltd.

Target Recruit Count: 517

Registration Number: NCT01082471

Locations: 🇵🇱
Ii Klinika Anestezjologii i It, Lublin, Poland
🇫🇷
Anaesthetisia - Resuscitation Department, Tenon Hospital, Paris, Cedex 20, France
🇩🇪
Universitätsklinikum Bonn, Klinik und Poliklinik f. Anaesthesiologie, Bonn, Germany

and more 4 locations

0.05 mg Versus 0.1 mg Spinal Morphine for Reducing Morphine Requirement After Vaginal Hysterectomy

Phase 4

Conditions: Pain

Interventions: Drug: Morphine

First Posted Date: 2010-03-04

Last Posted Date: 2011-09-07

Lead Sponsor: Mahidol University

Target Recruit Count: 72

Registration Number: NCT01080911

Locations: 🇹🇭
Faculty of Medicine, Siriraj Hospital, mahidol University, Bangkok, Thailand

Pharmacokinetics of Oral Morphine and Pharmacogenomics of CYP2D6 and UGT2B7, in an Urban Pediatric Population Presenting for Elective Surgery

Phase 2

Completed

Conditions: Pain

Interventions: Drug: Morphine

First Posted Date: 2010-02-19

Last Posted Date: 2017-07-05

Lead Sponsor: University of British Columbia

Target Recruit Count: 43

Registration Number: NCT01071499

Locations: 🇨🇦
British Columbia Children's Hospital-Dept of Anesthesia, Vancouver, British Columbia, Canada

Effect of Local Administration of Morphine for Analgesia After Iliac Bone Graft Harvest

Phase 4

Withdrawn

Conditions: Autogenous Bone Grafts

Interventions: Drug: morphine

First Posted Date: 2009-12-23

Last Posted Date: 2017-04-13

Lead Sponsor: The Cleveland Clinic

Registration Number: NCT01037335

Pain in Patients With Dementia and Behavioural Disturbances

Phase 2

Completed

Conditions: Dementia
Pain
Agitation

Interventions: Drug: Paracetamol
Drug: Morphine
Drug: Buprenorphine plaster
Drug: Pregabalin

First Posted Date: 2009-11-30

Last Posted Date: 2011-08-10

Lead Sponsor: University of Bergen

Target Recruit Count: 352

Registration Number: NCT01021696

Locations: 🇳🇴
Fantoft Omsorgssenter, Bergen, Hordaland, Norway
🇳🇴
Solsletten Sykehjem, Bergen, Hordaland, Norway
🇳🇴
Odinsvei Nursing Home, Nesttun, Hordaland, Norway

and more 15 locations