Ibuprofen

Generic Name: Ibuprofen

Brand Names: Addaprin, Advil, Advil Cold and Sinus, Advil Congestion Relief, Advil PM, Advil Sinus Congestion and Pain, Alivio, Caldolor, Cedaprin, Children's Ibuprofen, Diphen, Duexis, Ibu, Ibutab, Junior Strength Motrin, Motrin, Motrin PM, Neoprofen, Nuprin, Pedea, Proprinal, Reprexain, Sudafed PE Head Congestion Plus Pain, Vicoprofen, Wal-profen Congestion Relief and Pain, Ibuprofen Gen.Orph

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₈O_₂

CAS Number: 15687-27-1

Unique Ingredient Identifier: WK2XYI10QM

Background: Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally patented in 1961 and this drug was first launched against rheumatoid arthritis in the UK in 1969 and USA in 1974. It was the first available over-the-counter NSAID.

On the available products, ibuprofen is administered as a racemic mixture. Once administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer in vivo by the activity of the alpha-methylacyl-CoA racemase. In particular, it is generally proposed that the S-enantiomer is capable of eliciting stronger pharmacological activity than the R-enantiomer.

Indication: Ibuprofen is the most commonly used and prescribed NSAID. It is a very common over-the-counter medication widely used as an analgesic, anti-inflammatory and antipyretic.

The use of ibuprofen and its enantiomer Dexibuprofen in a racemic mix is common for the management of mild to moderate pain related to dysmenorrhea, headache, migraine, postoperative dental pain, spondylitis, osteoarthritis, rheumatoid arthritis, and soft tissue disorder.

Due to its activity against prostaglandin and thromboxane synthesis, ibuprofen has been attributed to alteration of platelet function and prolongation of gestation and labour.

As ibuprofen is a widely used medication, the main therapeutic indications are:

Associated Conditions: Acute Pain, Ankylosing Spondylitis (AS), Common Cold, Cystic Fibrosis (CF), Fever, Gastric Ulcer, Gout, Headache, Insomnia, Juvenile Idiopathic Arthritis (JIA), Menstrual Distress (Dysmenorrhea), Migraine, Mild pain, Nasal Congestion, Osteoarthritis (OA), Pain, Pain, Inflammatory, Patent Ductus Arteriosus (PDA), Pericarditis, Primary Dysmenorrhoea, Rheumatoid Arthritis, Severe Pain, Sinus pressure, Mild to moderate pain, Minor aches and pains, Moderate Pain

Clinical Trials

SCHF Post-Op Study Between Opioid and Non-Opioid Pain Management

Phase 4

Conditions: Supracondylar Humerus Fracture

Interventions: Drug: Hydrocodone/acetaminophen
Drug: Acetaminophen
Drug: Ibuprofen

First Posted Date: 2024-01-02

Last Posted Date: 2025-01-20

Lead Sponsor: Children's Mercy Hospital Kansas City

Target Recruit Count: 160

Registration Number: NCT06187584

Locations: 🇺🇸
Children's Mercy Hospital & Clinics, Kansas City, Missouri, United States

Comparision Between Paracetamol and Ibuprofen in Closure of Patent Ductus Arteriosus

Phase 2

Not yet recruiting

Conditions: Patent Ductus Arteriosus

Interventions: Drug: Paracetamol
Drug: Ibuprofen

First Posted Date: 2023-12-01

Last Posted Date: 2023-12-01

Lead Sponsor: Assiut University

Target Recruit Count: 56

Registration Number: NCT06152796

Effect of Acetaminophen Versus Ibuprofen in Treating Recurrent Apthous Ulcers in Pediatric Celiac Disease

Phase 4

Not yet recruiting

Conditions: Celiac Disease in Children

Interventions: Drug: Acetaminophen
Drug: Ibuprofen

First Posted Date: 2023-11-29

Last Posted Date: 2023-12-28

Lead Sponsor: Cairo University

Target Recruit Count: 12

Registration Number: NCT06149507

A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE.

Phase 4

Completed

Conditions: Total Shoulder Arthroplasty
Multimodal Analgesia
Postoperative Pain

Interventions: Drug: HTX-011
Drug: Bupivacaine Hydrochloride
Drug: Ibuprofen
Drug: Acetaminophen
Device: Luer lock applicator

First Posted Date: 2023-10-31

Last Posted Date: 2023-10-31

Lead Sponsor: Heron Therapeutics

Target Recruit Count: 30

Registration Number: NCT06109415

Locations: 🇺🇸
First Surgical Hospital, Bellaire, Texas, United States
🇺🇸
Legent Orthopedic Hospital, Carrollton, Texas, United States
🇺🇸
JBR Clinical Research, Salt Lake City, Utah, United States

and more 2 locations