Isradipine

Generic Name: Isradipine

Drug Type: Small Molecule

Chemical Formula: C_₁₉H_₂₁N_₃O_₅

CAS Number: 75695-93-1

Unique Ingredient Identifier: YO1UK1S598

Background: Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affinity and specificity and inhibits calcium flux into cardiac and arterial smooth muscle cells. It exhibits greater selectivity towards arterial smooth muscle cells owing to alternative splicing of the alpha-1 subunit of the channel and increased prevalence of inactive channels in smooth muscle cells. Isradipine may be used to treat mild to moderate essential hypertension.

Indication: 用于防治高血压、冠心病、心绞痛和充血性心力衰竭。

Associated Conditions: Hypertension

Clinical Trials

Isradipine Enhancement of Virtual Reality Cue Exposure for Smoking Cessation

Early Phase 1

Completed

Conditions: Nicotine Dependence
Smoking, Cigarette
Smoking Cessation
Smoking Behaviors
Smoking Reduction
Craving

Interventions: Drug: Isradipine
Behavioral: Cue Exposure

First Posted Date: 2017-03-20

Last Posted Date: 2024-01-10

Lead Sponsor: University of Texas at Austin

Target Recruit Count: 78

Registration Number: NCT03083353

Locations: 🇺🇸
University of Texas at Austin, Austin, Texas, United States

Efficacy of Isradipine in Early Parkinson Disease

Phase 3

Completed

Conditions: Parkinson Disease

Interventions: Drug: Isradipine
Drug: Placebo (for Isradipine)

First Posted Date: 2014-06-20

Last Posted Date: 2020-01-14

Lead Sponsor: University of Rochester

Target Recruit Count: 336

Registration Number: NCT02168842

Locations: 🇺🇸
University of California, Irvine, California, United States
🇺🇸
University of Rochester, Rochester, New York, United States
🇺🇸
Northwestern University, Chicago, Illinois, United States

and more 51 locations

Impact of Persistent Conductances on Motor Unit Firing in SCI

Not Applicable

Conditions: Chronic Spinal Cord Injury

Interventions: Drug: Memantine
Procedure: Therapeutic muscle stretching
Drug: sugar pill
Drug: Riluzole
Drug: Isradipine

First Posted Date: 2014-05-13

Last Posted Date: 2014-05-13

Lead Sponsor: Shirley Ryan AbilityLab

Target Recruit Count: 50

Registration Number: NCT02136823

Improving Buprenorphine Detoxification Outcomes With Isradipine

Phase 1

Completed

Conditions: Opioid Dependence

Interventions: Drug: Placebo
Drug: Isradipine

First Posted Date: 2013-07-10

Last Posted Date: 2017-06-05

Lead Sponsor: University of Arkansas

Target Recruit Count: 28

Registration Number: NCT01895270

Locations: 🇺🇸
UAMS Psychiatric Research Institute, Little Rock, Arkansas, United States

Adjunctive Isradipine for the Treatment of Bipolar Depression

Phase 2

Terminated

Conditions: Bipolar Disorder

Interventions: Drug: Isradipine
Drug: Placebo

First Posted Date: 2013-02-06

Last Posted Date: 2017-04-20

Lead Sponsor: Massachusetts General Hospital

Target Recruit Count: 2

Registration Number: NCT01784666

Locations: 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States

Evaluating Isradipine for Cognitive Enhancement in Schizophrenia and Schizoaffective Disorder

Not Applicable

Completed

Conditions: Schizophrenia
Schizoaffective Disorder

Interventions: Drug: isradipine

First Posted Date: 2012-08-06

Last Posted Date: 2018-12-05

Lead Sponsor: Icahn School of Medicine at Mount Sinai

Target Recruit Count: 11

Registration Number: NCT01658150

Locations: 🇺🇸
Icahn School of Medicine at Mount Sinai, New York, New York, United States

Safety, Tolerability and Efficacy Assessment of Dynacirc CR in Parkinson Disease

Phase 2

Completed

Conditions: Parkinson Disease

Interventions: Drug: Placebo
Drug: Isradipine CR 5mg
Drug: Isradipine CR 10mg
Drug: Isradipine CR 20mg

First Posted Date: 2009-05-28

Last Posted Date: 2013-04-17

Lead Sponsor: Northwestern University

Target Recruit Count: 99

Registration Number: NCT00909545

Locations: 🇺🇸
Emory University School of Medicine, Atlanta, Georgia, United States
🇺🇸
University of Pittsburgh, Pittsburgh, Pennsylvania, United States
🇺🇸
Rush University Medical Center, Chicago, Illinois, United States

and more 17 locations