Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

Lidocaine Versus Esmolol for Optimizing Surgical Field Visibility

Phase 2
Completed
Conditions
Interventions
First Posted Date
2020-02-07
Last Posted Date
2020-07-02
Lead Sponsor
Zagazig University
Target Recruit Count
70
Registration Number
NCT04260685
Locations
🇪🇬

Faculty of Medicine, Zagazig, Elsharkia, Egypt

Trial Evaluating the Efficacy of the Combination of ROpivacaine With Reference XYlocaine in the Evaluation of Pain During the Installation of Percutaneous Radiological GASTrostomy

Phase 2
Terminated
Conditions
Interventions
First Posted Date
2020-01-31
Last Posted Date
2024-01-31
Lead Sponsor
Centre Hospitalier Universitaire de Saint Etienne
Target Recruit Count
17
Registration Number
NCT04250805
Locations
🇫🇷

CHU de Saint-Etienne, Saint-Priest-en-Jarez, France

🇫🇷

Institut de Cancérologie Lucien Neuwirth, Saint-Priest-en-Jarez, France

Erector Spinae Plane Block Versus Perioperative Intravenous Lidocaine for Thoracotomy

First Posted Date
2020-01-09
Last Posted Date
2022-05-16
Lead Sponsor
Ataturk University
Target Recruit Count
60
Registration Number
NCT04221880
Locations
🇹🇷

Ataturk University, Erzurum, Turkey

Glenohumeral Cortisone Injection

Phase 2
Completed
Conditions
Interventions
First Posted Date
2020-01-02
Last Posted Date
2023-09-26
Lead Sponsor
University of Washington
Target Recruit Count
9
Registration Number
NCT04216017
Locations
🇺🇸

University of Washington, Seattle, Washington, United States

Efficacy of Repeated Locoregional Anesthetics Blocks With Bupivacaine in Patients Suffering of Chronic Dentoalveolar Pain.

Phase 2
Conditions
Interventions
First Posted Date
2019-12-20
Last Posted Date
2020-08-31
Lead Sponsor
University Hospital, Clermont-Ferrand
Target Recruit Count
50
Registration Number
NCT04207411
Locations
🇫🇷

CHU de Clermont-Ferrand, Clermont-Ferrand, France

Role of LIDOCAINE IN Pediatric Cochlear Implant Surgery

Phase 4
Completed
Conditions
Interventions
First Posted Date
2019-12-11
Last Posted Date
2020-05-01
Lead Sponsor
Wahba bakhet
Target Recruit Count
70
Registration Number
NCT04194294

Effect of Lidocaine Phonophoresis Versus Pulsed Ultrasound on Myofascial Pain Syndrome in Athletic Children

First Posted Date
2019-12-04
Last Posted Date
2019-12-04
Lead Sponsor
Cairo University
Target Recruit Count
50
Registration Number
NCT04185194
Locations
🇪🇬

faculty of physical therapy,Cairo University, Giza, Egypt

Effect of Intravenous Lidocaine on Immediate Post-operative Pain, Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy: A Randomized Placebo Controlled Trial

First Posted Date
2019-12-02
Last Posted Date
2019-12-03
Lead Sponsor
Aga Khan University Hospital, Pakistan
Target Recruit Count
120
Registration Number
NCT04182828
Locations
🇵🇰

Aga Khan University Hospital, Karachi, Sindh, Pakistan

Perioperative Analgesia on Postoperative Opioid Usage and Pain Control in H&N Cancer Surgery

First Posted Date
2019-11-25
Last Posted Date
2024-11-12
Lead Sponsor
Case Comprehensive Cancer Center
Target Recruit Count
30
Registration Number
NCT04176419
Locations
🇺🇸

Cleveland Clinic Taussig Cancer institute, Case Comprehensive Cancer Center, Cleveland, Ohio, United States

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