Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

Comparison of Bupivacaine Versus Bupivacaine-dexamethasone Infiltration for Postoperative Analgesia in Skin Graft Donor Sites

Phase 4
Completed
Conditions
Interventions
First Posted Date
2019-05-30
Last Posted Date
2019-05-30
Lead Sponsor
Ain Shams University
Target Recruit Count
100
Registration Number
NCT03967392
Locations
🇪🇬

Ramymahrose, Cairo, Egypt

Lidocaine Before Esophageal Manometry and Ambulatory pH Monitoring

Phase 2
Completed
Conditions
Interventions
First Posted Date
2019-05-30
Last Posted Date
2023-01-19
Lead Sponsor
Centre hospitalier de l'Université de Montréal (CHUM)
Target Recruit Count
304
Registration Number
NCT03967197
Locations
🇨🇦

Centre hospitalier de l'Université de Montréal, Montréal, Quebec, Canada

Transforaminal Epidural Injection in Acute Sciatica

First Posted Date
2019-04-23
Last Posted Date
2023-10-19
Lead Sponsor
C.L.A.Vleggeert-Lankamp
Target Recruit Count
142
Registration Number
NCT03924791
Locations
🇳🇱

Spaarne Gasthuis, Hoofddorp, Netherlands

Intravenous Lidocaine for Perioperative and Postoperative Analgesia

First Posted Date
2019-04-19
Last Posted Date
2019-04-22
Lead Sponsor
Rajmonda Nallbani-Komoni
Target Recruit Count
520
Registration Number
NCT03921567
Locations

University Clinical Centre of Kosovo, Pristina, Kosovo

University of Pristina, Faculty of Medicine, Pristina, Kosovo

Anesthesia Tumescent for Surgical Management of Tenosynovitis.

First Posted Date
2019-04-16
Last Posted Date
2019-04-29
Lead Sponsor
Instituto Mexicano del Seguro Social
Target Recruit Count
60
Registration Number
NCT03914235
Locations
🇲🇽

Western Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico

Impact of Lidocaine Administration on Postoperative Complications During Lung Resection Surgery

First Posted Date
2019-04-05
Last Posted Date
2021-08-25
Lead Sponsor
Francisco Andres de la Gala
Target Recruit Count
156
Registration Number
NCT03905837
Locations
🇪🇸

Hospital Gregorio Maranon, Madrid, Spain

Intravenous Lidocaine in Children Undergoing Laparoscopic Appendectomy

First Posted Date
2019-03-22
Last Posted Date
2020-05-19
Lead Sponsor
Medical University of Warsaw
Target Recruit Count
74
Registration Number
NCT03886896
Locations
🇵🇱

University Clinic Centre of Medical University of Warsaw, Warsaw, Poland

Open-Label CA-008 (Vocacapsaicin) in Bunionectomy

First Posted Date
2019-03-21
Last Posted Date
2021-10-27
Lead Sponsor
Concentric Analgesics
Target Recruit Count
36
Registration Number
NCT03885596
Locations
🇺🇸

Lotus Clinical Research, LLC, Pasadena, California, United States

Comparing the Efficacy of Local Anesthetics in Mohs Surgery

First Posted Date
2019-03-12
Last Posted Date
2020-06-16
Lead Sponsor
Ottawa Hospital Research Institute
Target Recruit Count
105
Registration Number
NCT03871478
Locations
🇨🇦

Mohs Surgery Clinic, Ottawa, Ontario, Canada

Efficacy of Guanfacine and Lidocaine Combination in Trigeminal Nerve Block for Pain Management in Trigeminal Neuropathy

Phase 2
Completed
Conditions
Interventions
First Posted Date
2019-03-07
Last Posted Date
2024-10-17
Lead Sponsor
Vanderbilt University Medical Center
Target Recruit Count
37
Registration Number
NCT03865940
Locations
🇺🇸

Vanderbilt University Medical Center, Nashville, Tennessee, United States

© Copyright 2024. All Rights Reserved by MedPath