Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

Radiofrequency and Chemical Neurolysis of Thoracic Splanchnic Nerve for Abdominal Cancer Pain

First Posted Date
2017-02-24
Last Posted Date
2017-02-28
Lead Sponsor
South Egypt Cancer Institute
Target Recruit Count
79
Registration Number
NCT03063112
Locations
🇪🇬

South Egypt Cancer Institute, Assuit, Assuit governrate, Egypt

PREMIX vs PREMED Intranasal Lidocaine and Midazolam

First Posted Date
2017-02-16
Last Posted Date
2019-09-11
Lead Sponsor
Columbia University
Target Recruit Count
55
Registration Number
NCT03054844
Locations
🇺🇸

Morgan Stanley Children's Hospital, New York, New York, United States

Pudendal Block Versus Penian Block For Circumcision In Children

First Posted Date
2017-02-08
Last Posted Date
2017-02-08
Lead Sponsor
Université Libre de Bruxelles
Target Recruit Count
60
Registration Number
NCT03046290
Locations
🇧🇪

Hopital Erasme, Bruxelles Capitale, Belgium

Lidocaine in ERAS for FESS

Phase 2
Completed
Conditions
Interventions
First Posted Date
2017-02-08
Last Posted Date
2022-04-28
Lead Sponsor
Assiut University
Target Recruit Count
43
Registration Number
NCT03047070
Locations
🇪🇬

Seham Mohamed Moeen Ibrahim, Asyut, Egypt

🇪🇬

Faculty of Medicine Assuit University, Assiut, Assuit, Egypt

Lidocaine Infusion in Radical Cystectomy

Phase 2
Completed
Conditions
Interventions
First Posted Date
2017-02-08
Last Posted Date
2018-08-07
Lead Sponsor
Assiut University
Target Recruit Count
57
Registration Number
NCT03047057
Locations
🇪🇬

Seham Mohamed Moeen Ibrahim, Asyut, Egypt

Investigation of the Effect of Intravenous Lidocaine Infusion on Postoperative Pain Treatment and Bowel Function in Robotic Bowel Surgery

Phase 4
Completed
Conditions
Interventions
First Posted Date
2017-02-07
Last Posted Date
2017-09-20
Lead Sponsor
Odense University Hospital
Target Recruit Count
60
Registration Number
NCT03044808
Locations
🇩🇰

Odense Universitetshospital, Odense, Denmark

Interscalene Nerve Block vs. Sedation for Shoulder Dislocation Reduction

First Posted Date
2017-02-02
Last Posted Date
2017-02-07
Lead Sponsor
Tel-Aviv Sourasky Medical Center
Target Recruit Count
90
Registration Number
NCT03041506

Longterm Postoperative Analgesia, Intravenous Lidocaine Infusion

First Posted Date
2017-01-25
Last Posted Date
2017-11-27
Lead Sponsor
Abdelrady S Ibrahim, MD
Target Recruit Count
40
Registration Number
NCT03030560
Locations
🇪🇬

Assiut university faculty of medicine, Assiut, Egypt

TPI Medication Comparison - Ketorolac, Lidocaine, or Dexamethasone

First Posted Date
2017-01-23
Last Posted Date
2020-11-18
Lead Sponsor
University of Utah
Target Recruit Count
10
Registration Number
NCT03028012
Locations
🇺🇸

University of Utah Orthopaedic Center, Salt Lake City, Utah, United States

Randomized Controlled Trial of Efficacy and Safety of Local Anesthetics and Steroids for Chronic Peripheral Post-traumatic Neuropathic Pain

First Posted Date
2017-01-04
Last Posted Date
2020-03-24
Lead Sponsor
University Health Network, Toronto
Target Recruit Count
3
Registration Number
NCT03009500
Locations
🇨🇦

Toronto Western Hospital, Toronto, Ontario, Canada

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