Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

Atracurium Mixed With Magnesium Sulfate Versus Atracurium Alone as Adjuvant to Lidocaine in IVRA

First Posted Date
2016-09-30
Last Posted Date
2018-06-12
Lead Sponsor
Assiut University
Target Recruit Count
75
Registration Number
NCT02920905
Locations
🇪🇬

Assiut University Hospital, Assiut, Egypt

Paracervical Block Versus No Paracervical Block During IUD Insertion

First Posted Date
2016-09-19
Last Posted Date
2018-11-07
Lead Sponsor
The University of Texas Health Science Center, Houston
Target Recruit Count
50
Registration Number
NCT02904915
Locations
🇺🇸

The University of Texas Health Science Center at Houston, Houston, Texas, United States

Intravenous Lidocaine and Ketorolac for Pain Management

First Posted Date
2016-09-16
Last Posted Date
2020-03-18
Lead Sponsor
Antonios Likourezos
Target Recruit Count
150
Registration Number
NCT02902770

Effect of Local Anesthesia on Postoperative Pain Following Sacrospinous Ligament Fixation

First Posted Date
2016-09-07
Last Posted Date
2016-10-12
Lead Sponsor
Hartford Hospital
Target Recruit Count
30
Registration Number
NCT02890199
Locations
🇺🇸

Hartford Hospital, Urogynecology Division, Hartford, Connecticut, United States

Cryoanesthesia for Intravitreal Injections

First Posted Date
2016-08-18
Last Posted Date
2019-09-17
Lead Sponsor
University of Michigan
Target Recruit Count
23
Registration Number
NCT02872012
Locations
🇺🇸

Kellogg Eye Center, Ann Arbor, Michigan, United States

Intra-operative Lidocaine Infusion in Preventing CPSP Post VATs

First Posted Date
2016-08-11
Last Posted Date
2018-10-24
Lead Sponsor
Lawson Health Research Institute
Target Recruit Count
120
Registration Number
NCT02862769
Locations
🇨🇦

London Health Sciences Centre, London, Ontario, Canada

A Pain Study Comparing Two Commonly Used Medications to Treat Pain After Bowel Surgery

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2016-07-29
Last Posted Date
2018-03-20
Lead Sponsor
Jacques E. Chelly
Target Recruit Count
68
Registration Number
NCT02849678
Locations
🇺🇸

UPMC Presbyterian Shadyside, Pittsburgh, Pennsylvania, United States

The Impact of Intravenous Anaesthesia on Angiogenesis in Patients With Breast Cancer (TIVA/TCI-BC)

First Posted Date
2016-07-21
Last Posted Date
2019-10-29
Lead Sponsor
Iuliu Hatieganu University of Medicine and Pharmacy
Target Recruit Count
120
Registration Number
NCT02839668
Locations
🇷🇴

IOCN Prof Dr I chiricuta, Cluj-Napoca, Romania

Compare Ultrasound Assisted Cold Therapy and Lidocaine Injection to Treat Morton's Neuroma

First Posted Date
2016-07-20
Last Posted Date
2018-11-06
Lead Sponsor
Icahn School of Medicine at Mount Sinai
Target Recruit Count
10
Registration Number
NCT02838758
Locations
🇺🇸

Icahn School of Medicine at Mount Sinai, New York, New York, United States

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